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Aliases for SERPINA2 Gene

Aliases for SERPINA2 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 2 (Gene/Pseudogene) 2 3
  • SERPINA2P 3 4 6
  • ARGS 3 4 6
  • ATR 3 4 6
  • PIL 3 4 6
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 2, Pseudogene 2 3
  • Serpin A2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 2 3
  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 2 2
  • Protease Inhibitor 1 (Alpha-1-Antitrypsin)-Like 2
  • Putative Alpha-1-Antitrypsin-Related Protein 3
  • Protease Inhibitor 1-Like 4
  • PsiATR 3

External Ids for SERPINA2 Gene

Previous HGNC Symbols for SERPINA2 Gene

  • PIL
  • SERPINA2P

Previous GeneCards Identifiers for SERPINA2 Gene

  • GC14M092337
  • GC14M088646
  • GC14M092820
  • GC14M093900
  • GC14M094830
  • GC14M075010

Summaries for SERPINA2 Gene

Entrez Gene Summary for SERPINA2 Gene

  • This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014]

GeneCards Summary for SERPINA2 Gene

SERPINA2 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with SERPINA2 include bacteriuria. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for SERPINA2 Gene

  • Putative serine protease inhibitor

Gene Wiki entry for SERPINA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA2 Gene

Genomics for SERPINA2 Gene

Regulatory Elements for SERPINA2 Gene

Genomic Location for SERPINA2 Gene

Start:
94,363,716 bp from pter
End:
94,366,702 bp from pter
Size:
2,987 bases
Orientation:
Minus strand

Genomic View for SERPINA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA2 Gene

Proteins for SERPINA2 Gene

  • Protein details for SERPINA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20848-A1ATR_HUMAN
    Recommended name:
    Putative alpha-1-antitrypsin-related protein
    Protein Accession:
    P20848
    Secondary Accessions:

    Protein attributes for SERPINA2 Gene

    Size:
    420 amino acids
    Molecular mass:
    47891 Da
    Quaternary structure:
    • Interacts with CANX AND PDIA3.

neXtProt entry for SERPINA2 Gene

Proteomics data for SERPINA2 Gene at MOPED

Post-translational modifications for SERPINA2 Gene

Other Protein References for SERPINA2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for SERPINA2 Gene

Domains for SERPINA2 Gene

Gene Families for SERPINA2 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20848

UniProtKB/Swiss-Prot:

A1ATR_HUMAN :
  • P20848
Domain:
  • The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA2: view

Function for SERPINA2 Gene

Molecular function for SERPINA2 Gene

UniProtKB/Swiss-Prot Function: Putative serine protease inhibitor

Gene Ontology (GO) - Molecular Function for SERPINA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 23826168
genes like me logo Genes that share ontologies with SERPINA2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA2 Gene

Localization for SERPINA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA2 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA2 Gene COMPARTMENTS Subcellular localization image for SERPINA2 gene
Compartment Confidence
extracellular 3
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SERPINA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IDA 23826168
genes like me logo Genes that share ontologies with SERPINA2: view

Pathways for SERPINA2 Gene

genes like me logo Genes that share pathways with SERPINA2: view

Interacting Proteins for SERPINA2 Gene

Gene Ontology (GO) - Biological Process for SERPINA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity TAS 2842251
genes like me logo Genes that share ontologies with SERPINA2: view

Compounds for SERPINA2 Gene

(6) Novoseek inferred chemical compound relationships for SERPINA2 Gene

Compound -log(P) Hits PubMed IDs
dihydrotestosterone 61.7 4
testosterone 45 9
serine 31.3 4
iron 9.83 1
oligonucleotide 0 2
genes like me logo Genes that share compounds with SERPINA2: view

Transcripts for SERPINA2 Gene

mRNA/cDNA for SERPINA2 Gene

(2376) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA2 Gene

No ASD Table

Relevant External Links for SERPINA2 Gene

GeneLoc Exon Structure for
SERPINA2
ECgene alternative splicing isoforms for
SERPINA2

Expression for SERPINA2 Gene

mRNA expression in normal human tissues for SERPINA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SERPINA2 Gene

mRNA Expression by UniProt/SwissProt for SERPINA2 Gene

P20848-A1ATR_HUMAN
Tissue specificity: Expressed in the liver, leukocytes and testis. Also detected in brain, colon, uterus, esophagus, spleen, trachea, kidney and lung.
genes like me logo Genes that share expressions with SERPINA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SERPINA2 Gene

Orthologs for SERPINA2 Gene

Evolution for SERPINA2 Gene

ENSEMBL:
Gene Tree for SERPINA2 (if available)
TreeFam:
Gene Tree for SERPINA2 (if available)

No data available for Orthologs for SERPINA2 Gene

Paralogs for SERPINA2 Gene

genes like me logo Genes that share paralogs with SERPINA2: view

No data available for Paralogs for SERPINA2 Gene

Variants for SERPINA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA2 Gene

P20848-A1ATR_HUMAN
The sequence shown is that of the V3 allele. Other alleles are: V1 and V2

Sequence variations from dbSNP and Humsavar for SERPINA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941595 -- 94,365,679(-) AACAT(A/G)CTTTA intron-variant
rs1815227 -- 94,365,477(-) ACAGA(A/G/T)ACCAT intron-variant
rs1950652 -- 94,367,999(-) GCTCC(C/T)GGTTC upstream-variant-2KB
rs1956172 -- 94,366,696(-) ACAAT(A/G)CCATT nc-transcript-variant
rs3762130 -- 94,368,524(-) GAGGA(C/G)ATCGG upstream-variant-2KB

Relevant External Links for SERPINA2 Gene

HapMap Linkage Disequilibrium report
SERPINA2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SERPINA2 Gene

Disorders for SERPINA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SERPINA2 Gene including...

Search for SERPINA2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SERPINA2 Gene

(4) Novoseek inferred disease relationships for SERPINA2 Gene

Disease -log(P) Hits PubMed IDs
alpha 1-antitrypsin deficiency 69.8 1
prostate cancer 42.6 7
tumors 0 1
cancer 0 1

Relevant External Links for SERPINA2

Genetic Association Database (GAD)
SERPINA2
Human Genome Epidemiology (HuGE) Navigator
SERPINA2
genes like me logo Genes that share disorders with SERPINA2: view

No data available for UniProtKB/Swiss-Prot for SERPINA2 Gene

Publications for SERPINA2 Gene

  1. Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2. (PMID: 17135331) Seixas S. … Di Rienzo A. (Mol. Biol. Evol. 2007) 3 4 23
  2. A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis. (PMID: 11161981) Borgmann S. … Fricke H. (Clin. Immunol. 2001) 3 23 48
  3. SERPINA2 is a novel gene with a divergent function from SERPINA1. (PMID: 23826168) Marques P.I. … Seixas S. (PLoS ONE 2013) 2 3 4
  4. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  5. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PMID: 15014966) Namciu S.J. … Fournier R.E. (Mamm. Genome 2004) 2 3

Products for SERPINA2 Gene

Sources for SERPINA2 Gene

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