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Aliases for OR52N4 Gene

Aliases for OR52N4 Gene

  • Olfactory Receptor, Family 52, Subfamily N, Member 4 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-64 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 2
  • Olfactory Receptor 52N4 3
  • OR11-64 3

External Ids for OR52N4 Gene

Previous GeneCards Identifiers for OR52N4 Gene

  • GC11U990484
  • GC11P005741

Summaries for OR52N4 Gene

Entrez Gene Summary for OR52N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N4 Gene

OR52N4 (Olfactory Receptor, Family 52, Subfamily N, Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52N4 Gene

  • Odorant receptor.

Gene Wiki entry for OR52N4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N4 Gene

Genomics for OR52N4 Gene

Regulatory Elements for OR52N4 Gene

Genomic Location for OR52N4 Gene

Start:
5,735,998 bp from pter
End:
5,755,932 bp from pter
Size:
19,935 bases
Orientation:
Plus strand

Genomic View for OR52N4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N4 Gene

Proteins for OR52N4 Gene

  • Protein details for OR52N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI2-O52N4_HUMAN
    Recommended name:
    Olfactory receptor 52N4
    Protein Accession:
    Q8NGI2
    Secondary Accessions:
    • B2RNP8
    • Q6IF77

    Protein attributes for OR52N4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N4 Gene

Proteomics data for OR52N4 Gene at MOPED

Post-translational modifications for OR52N4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR52N4 Gene

Domains for OR52N4 Gene

Gene Families for OR52N4 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52N4 Gene

Suggested Antigen Peptide Sequences for OR52N4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGI2

UniProtKB/Swiss-Prot:

O52N4_HUMAN :
  • Q8NGI2
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N4: view

Function for OR52N4 Gene

Molecular function for OR52N4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52N4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52N4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52N4 Gene

Localization for OR52N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52N4 Gene COMPARTMENTS Subcellular localization image for OR52N4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N4: view

Pathways for OR52N4 Gene

genes like me logo Genes that share pathways with OR52N4: view

Pathways by source for OR52N4 Gene

Interacting Proteins for OR52N4 Gene

Gene Ontology (GO) - Biological Process for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N4: view

Transcripts for OR52N4 Gene

mRNA/cDNA for OR52N4 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52N4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N4 Gene

No ASD Table

Relevant External Links for OR52N4 Gene

GeneLoc Exon Structure for
OR52N4
ECgene alternative splicing isoforms for
OR52N4

Expression for OR52N4 Gene

mRNA expression in normal human tissues for OR52N4 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N4 Gene

This gene is overexpressed in Nerve - Tibial (4.3) and Spleen (4.1).

SOURCE GeneReport for Unigene cluster for OR52N4 Gene Hs.553735

genes like me logo Genes that share expressions with OR52N4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR52N4 Gene

Orthologs for OR52N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52N4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR52N4 35
  • 85.46 (n)
  • 86.6 (a)
OR52N4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485294 35
  • 87.75 (n)
  • 89.1 (a)
OR52N4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr658 35
  • 84.94 (n)
  • 87.85 (a)
Olfr658 16
Olfr503 36
  • 83 (a)
OneToMany
Olfr658 36
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466392 35
  • 99.17 (n)
  • 97.51 (a)
OR52N4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr159 35
  • 84.11 (n)
  • 88.47 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490566 35
  • 58.55 (n)
  • 51.95 (a)
Species with no ortholog for OR52N4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N4 Gene

ENSEMBL:
Gene Tree for OR52N4 (if available)
TreeFam:
Gene Tree for OR52N4 (if available)

Paralogs for OR52N4 Gene

Selected SIMAP similar genes for OR52N4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52N4: view

Variants for OR52N4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N4 Gene

Q8NGI2-O52N4_HUMAN
A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans

Sequence variations from dbSNP and Humsavar for OR52N4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs868380 -- 5,741,194(-) AATCA(C/T)ACTGG intron-variant
rs883983 -- 5,741,159(-) ACAAT(C/G)TAGAG intron-variant
rs883984 -- 5,740,789(+) TGGAG(C/T)GTACA intron-variant
rs883985 -- 5,740,797(+) ACAGT(A/G)AGCCA intron-variant
rs1391639 -- 5,751,933(-) AATGT(C/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR52N4 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv341e1 CNV Complex 17122850
nsv896950 CNV Gain 21882294
nsv832058 CNV Gain 17160897
esv33342 CNV Loss 17666407
nsv896951 CNV Gain 21882294
dgv342e1 CNV Complex 17122850

Relevant External Links for OR52N4 Gene

HapMap Linkage Disequilibrium report
OR52N4

Disorders for OR52N4 Gene

No disorders were found for OR52N4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR52N4 Gene

Publications for OR52N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Different noses for different people. (PMID: 12730696) Menashe I. … Gilad Y. (Nat. Genet. 2003) 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52N4 Gene

Sources for OR52N4 Gene

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