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Aliases for RND3 Gene

Aliases for RND3 Gene

  • Rho Family GTPase 3 2 3 4 5
  • Rho-Related GTP-Binding Protein Rho8 3 4
  • Ras Homolog Gene Family, Member E 2 3
  • Protein MemB 3 4
  • Rho8 3 4
  • RhoE 3 4
  • ARHE 3 4
  • Small GTP Binding Protein Rho8 3
  • MemB 3
  • Rnd3 4

External Ids for RND3 Gene

Previous HGNC Symbols for RND3 Gene

  • ARHE

Previous GeneCards Identifiers for RND3 Gene

  • GC02M151151
  • GC02M151032
  • GC02M151324
  • GC02M143221

Summaries for RND3 Gene

Entrez Gene Summary for RND3 Gene

  • This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RND3 Gene

RND3 (Rho Family GTPase 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RND3 Gene

  • Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Gene Wiki entry for RND3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND3 Gene

Genomics for RND3 Gene

Regulatory Elements for RND3 Gene

Enhancers for RND3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RND3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RND3 Gene

150,468,193 bp from pter
150,539,011 bp from pter
70,819 bases
Minus strand

Genomic View for RND3 Gene

Genes around RND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND3 Gene

Proteins for RND3 Gene

  • Protein details for RND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoE
    Protein Accession:
    Secondary Accessions:
    • D3DP95
    • P52199

    Protein attributes for RND3 Gene

    244 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Binds ROCK1 (By similarity). Interacts with UBXD5.

    Three dimensional structures from OCA and Proteopedia for RND3 Gene

neXtProt entry for RND3 Gene

Proteomics data for RND3 Gene at MOPED

Post-translational modifications for RND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RND3 (RhoE)

No data available for DME Specific Peptides for RND3 Gene

Domains & Families for RND3 Gene

Gene Families for RND3 Gene

Suggested Antigen Peptide Sequences for RND3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND3: view

Function for RND3 Gene

Molecular function for RND3 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Gene Ontology (GO) - Molecular Function for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23622247
genes like me logo Genes that share ontologies with RND3: view
genes like me logo Genes that share phenotypes with RND3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RND3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RND3 Gene

Localization for RND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND3 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RND3 Gene COMPARTMENTS Subcellular localization image for RND3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RND3 Gene

Pathways & Interactions for RND3 Gene

genes like me logo Genes that share pathways with RND3: view

SIGNOR curated interactions for RND3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9531558
genes like me logo Genes that share ontologies with RND3: view

Drugs & Compounds for RND3 Gene

(3) Drugs for RND3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma Target 0

(2) Additional Compounds for RND3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND3: view

Transcripts for RND3 Gene

Unigene Clusters for RND3 Gene

Rho family GTPase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: -

Relevant External Links for RND3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RND3 Gene

mRNA expression in normal human tissues for RND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RND3 Gene

This gene is overexpressed in Fetal Brain (28.5), Spleen (22.8), Prostate (9.6), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RND3 Gene

SOURCE GeneReport for Unigene cluster for RND3 Gene Hs.6838

mRNA Expression by UniProt/SwissProt for RND3 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with RND3: view

Protein tissue co-expression partners for RND3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RND3 Gene

Orthologs for RND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RND3 35
  • 93.58 (n)
  • 100 (a)
RND3 36
  • 100 (a)
(Canis familiaris)
Mammalia LOC483917 35
  • 89.48 (n)
  • 99.59 (a)
RND3 36
  • 100 (a)
(Mus musculus)
Mammalia Rnd3 35
  • 93.03 (n)
  • 100 (a)
Rnd3 16
Rnd3 36
  • 100 (a)
(Pan troglodytes)
Mammalia RND3 35
  • 100 (n)
  • 100 (a)
RND3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnd3 35
  • 92.35 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RND3 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia RND3 36
  • 87 (a)
(Gallus gallus)
Aves RND3 35
  • 85.66 (n)
  • 97.95 (a)
RND3 36
  • 98 (a)
(Anolis carolinensis)
Reptilia RND3 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnd3 35
  • 81.69 (n)
  • 95.9 (a)
Str.17125 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4080 35
(Danio rerio)
Actinopterygii idibd2919 35
rnd3a 35
  • 78.05 (n)
  • 90.53 (a)
rnd3a 36
  • 91 (a)
rnd3b 36
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8918 35
Species with no ortholog for RND3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND3 Gene

Gene Tree for RND3 (if available)
Gene Tree for RND3 (if available)

Paralogs for RND3 Gene

genes like me logo Genes that share paralogs with RND3: view

Variants for RND3 Gene

Sequence variations from dbSNP and Humsavar for RND3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs707119 -- 150,473,154(+) AAAAA(A/G)AAAGA intron-variant
rs707123 -- 150,472,479(+) AACAA(G/T)AATTA intron-variant
rs816889 -- 150,468,781(+) GCTGC(A/G)TCTGT utr-variant-3-prime
rs816890 -- 150,471,193(+) TTTAT(A/G)AGAAT intron-variant
rs953278 -- 150,481,224(-) GCCAC(A/C)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RND3 Gene

Variant ID Type Subtype PubMed ID
nsv834414 CNV Gain 17160897

Variation tolerance for RND3 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RND3 Gene

Disorders for RND3 Gene

Relevant External Links for RND3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RND3 Gene

Publications for RND3 Gene

  1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PMID: 8649376) Foster R. … Settleman J. (Mol. Cell. Biol. 1996) 2 3 4 23 67
  2. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PMID: 19244113) Klein R.M. … Aplin A.E. (Cancer Res. 2009) 3 23
  3. RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. (PMID: 19850923) Villalonga P. … Ridley A.J. (J. Biol. Chem. 2009) 3 23
  4. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. (PMID: 18204440) Pinner S. … Sahai E. (Nat. Cell Biol. 2008) 3 23
  5. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. (PMID: 17182035) Poch E. … Guasch R.M. (Exp. Cell Res. 2007) 3 23

Products for RND3 Gene

Sources for RND3 Gene