Aliases for MAFA Gene
- MAF BZIP Transcription Factor A 2 3 5
- V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog A 2 3
- Pancreatic Beta-Cell-Specific Transcriptional Activator 3 4
- Transcription Factor RIPE3b1 3 4
- V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A 4
- Transcription Factor MafA 3
- RIPE3b1 3
- HMafA 3
External Ids for MAFA Gene
Previous GeneCards Identifiers for MAFA Gene
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]
GeneCards Summary for MAFA Gene
MAFA (MAF BZIP Transcription Factor A) is a Protein Coding gene. Diseases associated with MAFA include Fibrosarcoma and Monogenic Diabetes. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Regulation of beta-cell development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is MAF.
UniProtKB/Swiss-Prot for MAFA Gene
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.