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Aliases for GRXCR1 Gene

Aliases for GRXCR1 Gene

  • Glutaredoxin, Cysteine Rich 1 2 3
  • DFNB25 3 4
  • Glutaredoxin Domain-Containing Cysteine-Rich Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 88 3
  • Deafness, Autosomal Recessive 25 2
  • Protein Phosphatase 1 2
  • Regulatory Subunit 88 2
  • PPP1R88 3

External Ids for GRXCR1 Gene

Previous HGNC Symbols for GRXCR1 Gene

  • DFNB25

Previous GeneCards Identifiers for GRXCR1 Gene

  • GC04P042591
  • GC04P042217

Summaries for GRXCR1 Gene

Entrez Gene Summary for GRXCR1 Gene

  • This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]

GeneCards Summary for GRXCR1 Gene

GRXCR1 (Glutaredoxin, Cysteine Rich 1) is a Protein Coding gene. Diseases associated with GRXCR1 include deafness, autosomal recessive 25 and autosomal recessive non-syndromic sensorineural deafness type dfnb. GO annotations related to this gene include electron carrier activity and protein disulfide oxidoreductase activity. An important paralog of this gene is GRXCR2.

UniProtKB/Swiss-Prot for GRXCR1 Gene

  • May play a role in actin filament architecture in developing stereocilia of sensory cells.

Gene Wiki entry for GRXCR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRXCR1 Gene

Genomics for GRXCR1 Gene

Genomic Location for GRXCR1 Gene

42,893,266 bp from pter
43,030,658 bp from pter
137,393 bases
Plus strand

Genomic View for GRXCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRXCR1 Gene

Proteins for GRXCR1 Gene

  • Protein details for GRXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutaredoxin domain-containing cysteine-rich protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for GRXCR1 Gene

    290 amino acids
    Molecular mass:
    32294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRXCR1 Gene

Proteomics data for GRXCR1 Gene at MOPED

Post-translational modifications for GRXCR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRXCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRXCR1 Gene

Domains for GRXCR1 Gene

Gene Families for GRXCR1 Gene

Protein Domains for GRXCR1 Gene

Suggested Antigen Peptide Sequences for GRXCR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 glutaredoxin domain.
  • Belongs to the GRXCR1 family.
  • Contains 1 glutaredoxin domain.
  • Belongs to the GRXCR1 family.
genes like me logo Genes that share domains with GRXCR1: view

Function for GRXCR1 Gene

Molecular function for GRXCR1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in actin filament architecture in developing stereocilia of sensory cells.

Gene Ontology (GO) - Molecular Function for GRXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0009055 electron carrier activity IEA --
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0031072 heat shock protein binding --
GO:0051082 unfolded protein binding --
genes like me logo Genes that share ontologies with GRXCR1: view
genes like me logo Genes that share phenotypes with GRXCR1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRXCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRXCR1 Gene

Localization for GRXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRXCR1 Gene

Cell projection, stereocilium. Cell projection, microvillus. Cell projection, kinocilium. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GRXCR1 Gene COMPARTMENTS Subcellular localization image for GRXCR1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GRXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032420 stereocilium ISS --
GO:0060091 kinocilium ISS --
genes like me logo Genes that share ontologies with GRXCR1: view

Pathways for GRXCR1 Gene

SuperPathways for GRXCR1 Gene

No Data Available

Interacting Proteins for GRXCR1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000382670 for GRXCR1 Gene via STRING

Gene Ontology (GO) - Biological Process for GRXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound ISS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0042491 auditory receptor cell differentiation IEA --
GO:0045454 cell redox homeostasis IEA --
GO:0048563 post-embryonic organ morphogenesis IEA --
genes like me logo Genes that share ontologies with GRXCR1: view

No data available for Pathways by source for GRXCR1 Gene

Transcripts for GRXCR1 Gene

mRNA/cDNA for GRXCR1 Gene

(10) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRXCR1 Gene

Glutaredoxin, cysteine rich 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRXCR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRXCR1 Gene

No ASD Table

Relevant External Links for GRXCR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRXCR1 Gene

mRNA expression in normal human tissues for GRXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for GRXCR1 Gene

This gene is overexpressed in Testis (24.5), Brain - Nucleus accumbens (basal ganglia) (9.5), and Brain - Caudate (basal ganglia) (5.1).

Protein differential expression in normal tissues for GRXCR1 Gene

This gene is overexpressed in Lavage (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRXCR1 Gene

SOURCE GeneReport for Unigene cluster for GRXCR1 Gene Hs.162559

mRNA Expression by UniProt/SwissProt for GRXCR1 Gene

Tissue specificity: Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.
genes like me logo Genes that share expressions with GRXCR1: view

Expression partners for GRXCR1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GRXCR1 Gene

Orthologs for GRXCR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GRXCR1 35
  • 90 (n)
  • 94.14 (a)
  • 94 (a)
(Mus musculus)
Mammalia Grxcr1 35
  • 87.2 (n)
  • 92.73 (a)
Grxcr1 16
Grxcr1 36
  • 91 (a)
(Pan troglodytes)
Mammalia GRXCR1 35
  • 99.43 (n)
  • 99.31 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Grxcr1 35
  • 88.58 (n)
  • 92.04 (a)
(Bos Taurus)
Mammalia GRXCR1 36
  • 94 (a)
(Monodelphis domestica)
Mammalia GRXCR1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia GRXCR1 36
  • 79 (a)
(Gallus gallus)
Aves GRXCR1 35
  • 77.74 (n)
  • 81.66 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia GRXCR1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grxcr1 35
  • 75.49 (n)
  • 81.53 (a)
(Danio rerio)
Actinopterygii LOC100332873 35
  • 65.49 (n)
  • 68.2 (a)
grxcr1 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12206 36
  • 15 (a)
CG31559 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y46E12A.3 35
  • 48.17 (n)
  • 34.07 (a)
Y46E12A.3 36
  • 27 (a)
Species with no ortholog for GRXCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRXCR1 Gene

Gene Tree for GRXCR1 (if available)
Gene Tree for GRXCR1 (if available)

Paralogs for GRXCR1 Gene

Paralogs for GRXCR1 Gene

genes like me logo Genes that share paralogs with GRXCR1: view

Variants for GRXCR1 Gene

Sequence variations from dbSNP and Humsavar for GRXCR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs726270 -- 42,894,463(-) GCTAC(C/T)TTAAT intron-variant
rs747080 -- 42,933,155(-) GGATG(C/T)GTCCT intron-variant
rs747081 -- 42,933,103(-) GCCTA(A/T)TTCTC intron-variant
rs748329 -- 42,952,508(+) CCACC(C/T)TCTCC intron-variant
rs748330 -- 42,952,543(+) TGTCA(A/G)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRXCR1 Gene

Variant ID Type Subtype PubMed ID
nsv525721 CNV Loss 19592680
dgv872n67 CNV Loss 20364138
esv5262 CNV Deletion 18987735
esv2727494 CNV Deletion 23290073
esv2658687 CNV Deletion 23128226
esv7471 CNV Loss 19470904
esv2727495 CNV Deletion 23290073
nsv293526 CNV Loss 16902084
nsv291473 CNV Loss 16902084

Relevant External Links for GRXCR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRXCR1 Gene

Disorders for GRXCR1 Gene

(1) OMIM Diseases for GRXCR1 Gene (613283)


  • Deafness, autosomal recessive, 25 (DFNB25) [MIM:613285]: A form of non-syndromic sensorineural deafness characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals, and vestibular dysfunction is observed in some affected individuals. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:20137774, ECO:0000269 PubMed:20137778}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for GRXCR1 Gene

Relevant External Links for GRXCR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GRXCR1: view

No data available for Novoseek inferred disease relationships and Genatlas for GRXCR1 Gene

Publications for GRXCR1 Gene

  1. Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment. (PMID: 20137778) Schraders M. … Kremer H. (Am. J. Hum. Genet. 2010) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3
  4. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3
  5. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3

Products for GRXCR1 Gene

Sources for GRXCR1 Gene

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