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Aliases for RHOC Gene

Aliases for RHOC Gene

  • Ras Homolog Family Member C 2 3 5
  • Ras Homolog Gene Family, Member C 2 3
  • Rho CDNA Clone 9 3 4
  • ARH9 3 4
  • ARHC 3 4
  • H9 3 4
  • Small GTP Binding Protein RhoC 3
  • RAS-Related Homolog 9 3
  • Oncogene RHO H9 3
  • RhoC GTPase 3
  • RHOH9 3

External Ids for RHOC Gene

Previous HGNC Symbols for RHOC Gene

  • ARH9
  • ARHC

Previous GeneCards Identifiers for RHOC Gene

  • GC01M112544
  • GC01M112955
  • GC01M113243
  • GC01M111103

Summaries for RHOC Gene

Entrez Gene Summary for RHOC Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RHOC Gene

RHOC (Ras Homolog Family Member C) is a Protein Coding gene. Diseases associated with RHOC include tongue squamous cell carcinoma and breast cancer. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOC Gene

  • Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Gene Wiki entry for RHOC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOC Gene

Genomics for RHOC Gene

Regulatory Elements for RHOC Gene

Promoters for RHOC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOC on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOC Gene

Chromosome:
1
Start:
112,701,106 bp from pter
End:
112,707,434 bp from pter
Size:
6,329 bases
Orientation:
Minus strand

Genomic View for RHOC Gene

Genes around RHOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOC Gene

Proteins for RHOC Gene

  • Protein details for RHOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08134-RHOC_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Protein Accession:
    P08134
    Secondary Accessions:
    • B3KSW1
    • Q6ICN3

    Protein attributes for RHOC Gene

    Size:
    193 amino acids
    Molecular mass:
    22006 Da
    Quaternary structure:
    • Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA.

    Three dimensional structures from OCA and Proteopedia for RHOC Gene

neXtProt entry for RHOC Gene

Proteomics data for RHOC Gene at MOPED

Post-translational modifications for RHOC Gene

  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RHOC (RHOC)

No data available for DME Specific Peptides for RHOC Gene

Domains & Families for RHOC Gene

Gene Families for RHOC Gene

Suggested Antigen Peptide Sequences for RHOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08134

UniProtKB/Swiss-Prot:

RHOC_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOC: view

Function for RHOC Gene

Molecular function for RHOC Gene

UniProtKB/Swiss-Prot Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.
genes like me logo Genes that share phenotypes with RHOC: view

Animal Models for RHOC Gene

MGI Knock Outs for RHOC:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHOC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOC Gene

Localization for RHOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOC Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOC Gene COMPARTMENTS Subcellular localization image for RHOC gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RHOC: view

Pathways & Interactions for RHOC Gene

genes like me logo Genes that share pathways with RHOC: view

SIGNOR curated interactions for RHOC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IDA 16236794
GO:0007165 signal transduction IEA --
GO:0044319 wound healing, spreading of cells ISS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0060193 positive regulation of lipase activity IDA 19887681
genes like me logo Genes that share ontologies with RHOC: view

Drugs & Compounds for RHOC Gene

(3) Additional Compounds for RHOC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOC: view

Transcripts for RHOC Gene

Unigene Clusters for RHOC Gene

Ras homolog family member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -

Relevant External Links for RHOC Gene

GeneLoc Exon Structure for
RHOC
ECgene alternative splicing isoforms for
RHOC

Expression for RHOC Gene

mRNA expression in normal human tissues for RHOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHOC Gene

This gene is overexpressed in Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOC Gene



SOURCE GeneReport for Unigene cluster for RHOC Gene Hs.502659

genes like me logo Genes that share expression patterns with RHOC: view

Protein tissue co-expression partners for RHOC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RHOC Gene

Orthologs for RHOC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHOC 35
  • 93.44 (n)
  • 100 (a)
RHOC 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOC 35
  • 93.09 (n)
  • 100 (a)
RHOC 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoc 35
  • 92.06 (n)
  • 100 (a)
Rhoc 16
Rhoc 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHOC 35
  • 99.48 (n)
  • 100 (a)
RHOC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhoc 35
  • 92.57 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOC 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOC 35
  • 85.15 (n)
  • 96.89 (a)
RHOC 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOC 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoc 35
  • 77.2 (n)
  • 91.71 (a)
zebrafish
(Danio rerio)
Actinopterygii rhoad 35
  • 77.2 (n)
  • 93.26 (a)
zgc64015 35
rhoad 36
  • 93 (a)
OneToMany
rhoae 36
  • 93 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1986 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005160 35
  • 72.87 (n)
  • 88.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rho1 35
  • 72.16 (n)
  • 86.7 (a)
Rho1 36
  • 85 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 35
  • 70.49 (n)
  • 84.9 (a)
rho-1 36
  • 85 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR182W 35
  • 62.81 (n)
  • 64.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 36
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 36
  • 82 (a)
OneToMany
Species with no ortholog for RHOC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOC Gene

ENSEMBL:
Gene Tree for RHOC (if available)
TreeFam:
Gene Tree for RHOC (if available)

Paralogs for RHOC Gene

genes like me logo Genes that share paralogs with RHOC: view

Variants for RHOC Gene

Sequence variations from dbSNP and Humsavar for RHOC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11538959 - 112,702,613(-) AGAAG(C/G)ACCTG reference, missense
rs937053 -- 112,703,607(-) CTGAG(A/T)CCCCG intron-variant
rs1059340 -- 112,701,477(-) CCCTA(A/C)AACCC utr-variant-3-prime
rs1059411 -- 112,701,360(-) GCGCT(C/T)TGGGA utr-variant-3-prime
rs1059479 -- 112,701,270(-) CCAGC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHOC Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
essv21692 CNV CNV 17122850
esv27598 CNV Loss 19812545
dgv332n71 CNV Loss 21882294
esv2716318 CNV Deletion 23290073
esv2414426 CNV Deletion 18987734
esv2716329 CNV Deletion 23290073

Variation tolerance for RHOC Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOC Gene

HapMap Linkage Disequilibrium report
RHOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOC Gene

Disorders for RHOC Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tongue squamous cell carcinoma
  • squamous-cell carcinoma
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search RHOC in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOC

Genetic Association Database (GAD)
RHOC
Human Genome Epidemiology (HuGE) Navigator
RHOC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOC
genes like me logo Genes that share disorders with RHOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOC Gene

Publications for RHOC Gene

  1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P. … Tavitian A. (Nucleic Acids Res. 1988) 2 3 4 67
  2. Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC. (PMID: 20101212) Kitzing T.M. … Grosse R. (Oncogene 2010) 3 23
  3. Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma. (PMID: 20232393) Jiang L. … Zhou X. (Int. J. Cancer 2010) 3 23
  4. Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. (PMID: 19477269) Hutchison N. … Sharpe C.C. (Cell. Signal. 2009) 3 23
  5. Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters. (PMID: 19499974) Wang H.B. … Liu Y.J. (Clin. Chem. Lab. Med. 2009) 3 23

Products for RHOC Gene

Sources for RHOC Gene

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