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Aliases for RHOC Gene

Aliases for RHOC Gene

  • Ras Homolog Family Member C 2 3
  • ARH9 3 4 6
  • ARHC 3 4 6
  • Ras Homolog Gene Family, Member C 2 3
  • Rho CDNA Clone 9 3 4
  • RHOH9 3 6
  • H9 3 4
  • Rho-Related GTP-Binding Protein RhoC 3
  • Small GTP Binding Protein RhoC 3
  • RAS-Related Homolog 9 3
  • Oncogene RHO H9 3
  • RhoC GTPase 3

External Ids for RHOC Gene

Previous Symbols for RHOC Gene

  • ARH9
  • ARHC

Summaries for RHOC Gene

Entrez Gene Summary for RHOC Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RHOC Gene

RHOC (Ras Homolog Family Member C) is a Protein Coding gene. Diseases associated with RHOC include hepatocellular carcinoma and breast cancer. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOC Gene

  • Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Gene Wiki entry for RHOC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOC Gene

Genomics for RHOC Gene

Genomic Location for RHOC Gene

Start:
112,701,106 bp from pter
End:
112,707,434 bp from pter
Size:
6,329 bases
Orientation:
Minus strand

Genomic View for RHOC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOC Gene

Regulatory Elements for RHOC Gene

Proteins for RHOC Gene

  • Protein details for RHOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08134-RHOC_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Protein Accession:
    P08134
    Secondary Accessions:
    • B3KSW1
    • Q6ICN3

    Protein attributes for RHOC Gene

    Size:
    193 amino acids
    Molecular mass:
    22006 Da
    Quaternary structure:
    • Interacts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA.

    Three dimensional structures from OCA and Proteopedia for RHOC Gene

neXtProt entry for RHOC Gene

Proteomics data for RHOC Gene at MOPED

Post-translational modifications for RHOC Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys104

No data available for DME Specific Peptides for RHOC Gene

Domains for RHOC Gene

UniProtKB/Swiss-Prot:

RHOC_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P08134
genes like me logo Genes that share domains with RHOC: view

No data available for Gene Families for RHOC Gene

Function for RHOC Gene

Molecular function for RHOC Gene

UniProtKB/Swiss-Prot Function: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Gene Ontology (GO) - Molecular Function for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 20974804
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOC: view

Phenotypes for RHOC Gene

genes like me logo Genes that share phenotypes with RHOC: view

Animal Models for RHOC Gene

MGI Knock Outs for RHOC:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHOC Gene

Localization for RHOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOC Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOC Gene COMPARTMENTS Subcellular localization image for RHOC gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RHOC: view

Pathways for RHOC Gene

genes like me logo Genes that share pathways with RHOC: view

Pathways by source for RHOC Gene

1 R&D Systems pathway for RHOC Gene
1 Cell Signaling Technology pathway for RHOC Gene

Gene Ontology (GO) - Biological Process for RHOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IDA 16236794
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with RHOC: view

Compounds for RHOC Gene

(3) Novoseek inferred chemical compound relationships for RHOC Gene

Compound -log(P) Hits PubMed IDs
gdp 57.9 1
gtp 36.8 3
vegf 18.4 2
genes like me logo Genes that share compounds with RHOC: view

Transcripts for RHOC Gene

Unigene Clusters for RHOC Gene

Ras homolog family member C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -

Relevant External Links for RHOC Gene

GeneLoc Exon Structure for
RHOC
ECgene alternative splicing isoforms for
RHOC

Expression for RHOC Gene

mRNA expression in normal human tissues for RHOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOC Gene

SOURCE GeneReport for Unigene cluster for RHOC Gene Hs.502659

genes like me logo Genes that share expressions with RHOC: view

Orthologs for RHOC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOC 36
  • 99.48 (n)
  • 100 (a)
RHOC 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOC 36
  • 93.44 (n)
  • 100 (a)
RHOC 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOC 36
  • 93.09 (n)
  • 100 (a)
RHOC 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoc 36
  • 92.06 (n)
  • 100 (a)
Rhoc 16
Rhoc 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOC 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhoc 36
  • 92.57 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RHOC 36
  • 85.15 (n)
  • 96.89 (a)
RHOC 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOC 37
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhoc 36
  • 77.2 (n)
  • 91.71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1986 36
zebrafish
(Danio rerio)
Actinopterygii rhoad 36
  • 77.2 (n)
  • 93.26 (a)
rhoad 37
  • 93 (a)
OneToMany
rhoae 37
  • 93 (a)
OneToMany
zgc64015 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005160 36
  • 72.87 (n)
  • 88.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rho1 36
  • 72.16 (n)
  • 86.7 (a)
Rho1 37
  • 85 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 36
  • 70.49 (n)
  • 84.9 (a)
rho-1 37
  • 85 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR182W 36
  • 62.81 (n)
  • 64.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 37
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 37
  • 82 (a)
OneToMany
Species with no ortholog for RHOC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOC Gene

ENSEMBL:
Gene Tree for RHOC (if available)
TreeFam:
Gene Tree for RHOC (if available)

Paralogs for RHOC Gene

Paralogs for RHOC Gene

genes like me logo Genes that share paralogs with RHOC: view

Variants for RHOC Gene

Sequence variations from dbSNP and Humsavar for RHOC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs937053 -- 112,703,607(-) CTGAG(A/T)CCCCG intron-variant
rs954679 -- 112,705,743(+) TTTGT(A/G)AAGAT intron-variant
rs1059340 -- 112,701,477(-) CCCTA(A/C)AACCC utr-variant-3-prime
rs1059411 -- 112,701,360(-) GCGCT(C/T)TGGGA utr-variant-3-prime
rs1059479 -- 112,701,270(-) CCAGC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHOC Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
essv21692 CNV CNV 17122850
esv27598 CNV Loss 19812545
dgv332n71 CNV Loss 21882294
esv2716318 CNV Deletion 23290073
esv2414426 CNV Deletion 18987734
esv2716329 CNV Deletion 23290073

Relevant External Links for RHOC Gene

HapMap Linkage Disequilibrium report
RHOC

Disorders for RHOC Gene

(16) Novoseek inferred disease relationships for RHOC Gene

Disease -log(P) Hits PubMed IDs
inflammatory breast cancer 82.5 2
metastasis 57.2 42
tumors 42.1 34
breast cancer 42 22
cancer 38.9 8

Relevant External Links for RHOC

Genetic Association Database (GAD)
RHOC
Human Genome Epidemiology (HuGE) Navigator
RHOC
genes like me logo Genes that share disorders with RHOC: view

No data available for UniProtKB/Swiss-Prot for RHOC Gene

Publications for RHOC Gene

  1. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. (PMID: 8816443) Leung T. … Lim L. (Mol. Cell. Biol. 1996) 3 4 23
  2. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P. … Tavitian A. (Nucleic Acids Res. 1988) 2 3 4
  3. AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. (PMID: 11546812) Diviani D. … Scott J.D. (J. Biol. Chem. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for RHOC Gene

  • Addgene plasmids for RHOC

Sources for RHOC Gene

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