Aliases for HES5 Gene
External Ids for HES5 Gene
Previous GeneCards Identifiers for HES5 Gene
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
GeneCards Summary for HES5 Gene
HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4.
UniProtKB/Swiss-Prot for HES5 Gene
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).