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Aliases for KRTDAP Gene

Aliases for KRTDAP Gene

  • Keratinocyte Differentiation-Associated Protein 2 3
  • KDAP 3 4
  • KIPV467 3
  • UNQ467 3

External Ids for KRTDAP Gene

Previous GeneCards Identifiers for KRTDAP Gene

  • GC19U990285
  • GC19M040654
  • GC19M040671
  • GC19M035978
  • GC19M032483

Summaries for KRTDAP Gene

Entrez Gene Summary for KRTDAP Gene

  • This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for KRTDAP Gene

KRTDAP (Keratinocyte Differentiation-Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTDAP Gene

  • May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.

Gene Wiki entry for KRTDAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTDAP Gene

Genomics for KRTDAP Gene

Regulatory Elements for KRTDAP Gene

Genomic Location for KRTDAP Gene

Start:
35,487,324 bp from pter
End:
35,495,558 bp from pter
Size:
8,235 bases
Orientation:
Minus strand

Genomic View for KRTDAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTDAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTDAP Gene

Proteins for KRTDAP Gene

  • Protein details for KRTDAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60985-KTDAP_HUMAN
    Recommended name:
    Keratinocyte differentiation-associated protein
    Protein Accession:
    P60985
    Secondary Accessions:
    • A1L4D7

    Protein attributes for KRTDAP Gene

    Size:
    99 amino acids
    Molecular mass:
    11050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRTDAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTDAP Gene

Proteomics data for KRTDAP Gene at MOPED

Post-translational modifications for KRTDAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTDAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTDAP Gene

Domains for KRTDAP Gene

Protein Domains for KRTDAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTDAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTDAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRTDAP Gene

Function for KRTDAP Gene

Molecular function for KRTDAP Gene

UniProtKB/Swiss-Prot Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
UniProtKB/Swiss-Prot Induction: Up-regulated in situ in psoriatic skin (at protein level).

Phenotypes for KRTDAP Gene

GenomeRNAi human phenotypes for KRTDAP:
genes like me logo Genes that share phenotypes with KRTDAP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTDAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTDAP Gene

Localization for KRTDAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTDAP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTDAP Gene COMPARTMENTS Subcellular localization image for KRTDAP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KRTDAP: view

Pathways for KRTDAP Gene

SuperPathways for KRTDAP Gene

No Data Available

Interacting Proteins for KRTDAP Gene

Gene Ontology (GO) - Biological Process for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with KRTDAP: view

No data available for Pathways by source for KRTDAP Gene

Transcripts for KRTDAP Gene

mRNA/cDNA for KRTDAP Gene

Unigene Clusters for KRTDAP Gene

Keratinocyte differentiation-associated protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTDAP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTDAP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTDAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for KRTDAP Gene

GeneLoc Exon Structure for
KRTDAP
ECgene alternative splicing isoforms for
KRTDAP

Expression for KRTDAP Gene

mRNA expression in normal human tissues for KRTDAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTDAP Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (21.5), Skin - Sun Exposed (Lower leg) (20.1), and Vagina (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTDAP Gene

SOURCE GeneReport for Unigene cluster for KRTDAP Gene Hs.112457

mRNA Expression by UniProt/SwissProt for KRTDAP Gene

P60985-KTDAP_HUMAN
Tissue specificity: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.
genes like me logo Genes that share expressions with KRTDAP: view

In Situ Assay Products

Orthologs for KRTDAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTDAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTDAP 35
  • 98.65 (n)
  • 98.99 (a)
KRTDAP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRTDAP 35
  • 85.86 (n)
  • 84.85 (a)
KRTDAP 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTDAP 35
  • 86.2 (n)
  • 87.88 (a)
KRTDAP 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtdap 35
  • 69.7 (n)
  • 56.57 (a)
Krtdap 16
Krtdap 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRTDAP 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRTDAP 36
  • 63 (a)
OneToOne
Species with no ortholog for KRTDAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTDAP Gene

ENSEMBL:
Gene Tree for KRTDAP (if available)
TreeFam:
Gene Tree for KRTDAP (if available)

Paralogs for KRTDAP Gene

No data available for Paralogs for KRTDAP Gene

Variants for KRTDAP Gene

Sequence variations from dbSNP and Humsavar for KRTDAP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7976 -- 35,487,397(-) CTAGC(A/G)TGAGC utr-variant-3-prime
rs1006767 -- 35,488,960(-) GGGAA(C/T)GGGTT intron-variant
rs1007567 -- 35,489,617(+) ACAGC(C/G/T)CCCCC intron-variant
rs1007568 -- 35,489,930(+) TCTCC(A/G)CCTGC intron-variant
rs2293690 -- 35,487,675(+) TACCC(C/T)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRTDAP Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV Gain 17160897

Relevant External Links for KRTDAP Gene

HapMap Linkage Disequilibrium report
KRTDAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTDAP Gene

Disorders for KRTDAP Gene

No disorders were found for KRTDAP Gene.

No data available for UniProtKB/Swiss-Prot for KRTDAP Gene

Publications for KRTDAP Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Characterization of Kdap, a protein secreted by keratinocytes. (PMID: 15140226) Tsuchida S. … Ariizumi K. (J. Invest. Dermatol. 2004) 3 4
  3. Kdap, a novel gene associated with the stratification of the epithelium. (PMID: 11054531) Oomizu S. … Yoshizato K. (Gene 2000) 2 3
  4. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTDAP Gene

Sources for KRTDAP Gene

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