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Aliases for KRTDAP Gene

Aliases for KRTDAP Gene

  • Keratinocyte Differentiation Associated Protein 2 3 5
  • KDAP 3 4
  • Keratinocyte Differentiation-Associated Protein 3
  • KIPV467 3
  • UNQ467 3

External Ids for KRTDAP Gene

Previous GeneCards Identifiers for KRTDAP Gene

  • GC19U990285
  • GC19M040654
  • GC19M040671
  • GC19M035978
  • GC19M032483
  • GC19M035764
  • GC19M035921
  • GC19M035947
  • GC19M036816
  • GC19M037436

Summaries for KRTDAP Gene

Entrez Gene Summary for KRTDAP Gene

  • This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for KRTDAP Gene

KRTDAP (Keratinocyte Differentiation Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTDAP Gene

  • May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.

Gene Wiki entry for KRTDAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTDAP Gene

Genomics for KRTDAP Gene

Regulatory Elements for KRTDAP Gene

Enhancers for KRTDAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035328 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 +164.5 164524 5.1 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF416 TMEM147-AS1 MAG KMT2B ZNF792 ZNF146 RBM42 CD22 ENSG00000271032 KRTDAP DMKN
GH19G035435 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +58.8 58826 2.7 HDAC1 PKNOX1 ZNF473 YY1 ZNF121 FOS RELB ETV6 IKZF2 ZNF263 TMEM147-AS1 NFKBID ZFP14 ZFP82 FFAR2 LIN37 KRTDAP DMKN LINC00665 CD22
GH19G035430 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +64.4 64352 1.6 PKNOX1 ZNF493 ZFP64 ZNF155 ZEB1 ZNF138 ZNF354C KLF7 ZNF548 ZNF202 TMEM147-AS1 ZNF792 HAUS5 ZFP82 RBM42 LINC00665 KMT2B ZNF146 LOC100134317 SDHAF1
GH19G035304 1.6 Ensembl ENCODE dbSUPER 10.4 +187.6 187595 6.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT MLX ARID4B ZNF766 CBX5 FOS MAG CD22 LSR HAMP DMKN FAM187B KRTDAP ENSG00000233214 ENSG00000232680 ATP4A
GH19G035388 1.4 FANTOM5 ENCODE 10.7 +106.6 106571 1.5 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 TMEM147-AS1 ZNF792 HAUS5 LINC00665 LOC100134317 KMT2B RBM42 ENSG00000233214 ENSG00000267388 ALKBH6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRTDAP on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTDAP Gene

35,487,324 bp from pter
35,495,558 bp from pter
8,235 bases
Minus strand

Genomic View for KRTDAP Gene

Genes around KRTDAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTDAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTDAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTDAP Gene

Proteins for KRTDAP Gene

  • Protein details for KRTDAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte differentiation-associated protein
    Protein Accession:
    Secondary Accessions:
    • A1L4D7

    Protein attributes for KRTDAP Gene

    99 amino acids
    Molecular mass:
    11050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRTDAP Gene


neXtProt entry for KRTDAP Gene

Post-translational modifications for KRTDAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTDAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTDAP Gene

Domains & Families for KRTDAP Gene

Protein Domains for KRTDAP Gene


Suggested Antigen Peptide Sequences for KRTDAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTDAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KRTDAP Gene

Function for KRTDAP Gene

Molecular function for KRTDAP Gene

UniProtKB/Swiss-Prot Function:
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in situ in psoriatic skin (at protein level).
genes like me logo Genes that share phenotypes with KRTDAP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTDAP Gene

Localization for KRTDAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTDAP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTDAP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with KRTDAP: view

Pathways & Interactions for KRTDAP Gene

SuperPathways for KRTDAP Gene

No Data Available

Interacting Proteins for KRTDAP Gene

Gene Ontology (GO) - Biological Process for KRTDAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with KRTDAP: view

No data available for Pathways by source and SIGNOR curated interactions for KRTDAP Gene

Transcripts for KRTDAP Gene


Unigene Clusters for KRTDAP Gene

Keratinocyte differentiation-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTDAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for KRTDAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTDAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTDAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTDAP Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x21.5), Skin - Sun Exposed (Lower leg) (x20.1), and Vagina (x6.8).

Protein differential expression in normal tissues from HIPED for KRTDAP Gene

This gene is overexpressed in Oral epithelium (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTDAP Gene

NURSA nuclear receptor signaling pathways regulating expression of KRTDAP Gene:


SOURCE GeneReport for Unigene cluster for KRTDAP Gene:


mRNA Expression by UniProt/SwissProt for KRTDAP Gene:

Tissue specificity: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.

Evidence on tissue expression from TISSUES for KRTDAP Gene

  • Skin(3.6)
genes like me logo Genes that share expression patterns with KRTDAP: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTDAP Gene

Orthologs for KRTDAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTDAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRTDAP 34 35
  • 98.65 (n)
(Canis familiaris)
Mammalia KRTDAP 34 35
  • 86.2 (n)
(Bos Taurus)
Mammalia KRTDAP 34 35
  • 85.86 (n)
(Mus musculus)
Mammalia Krtdap 34 16 35
  • 69.7 (n)
(Ornithorhynchus anatinus)
Mammalia KRTDAP 35
  • 63 (a)
(Monodelphis domestica)
Mammalia KRTDAP 35
  • 56 (a)
Species where no ortholog for KRTDAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTDAP Gene

Gene Tree for KRTDAP (if available)
Gene Tree for KRTDAP (if available)

Paralogs for KRTDAP Gene

No data available for Paralogs for KRTDAP Gene

Variants for KRTDAP Gene

Sequence variations from dbSNP and Humsavar for KRTDAP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000184906 -- 35,488,540(+) GAGCT(C/T)AGCCC intron-variant
rs1000258648 -- 35,488,376(+) AAAAT(A/G)TGTGG intron-variant
rs1000519343 -- 35,489,729(+) GACTG(G/T)ATGGT intron-variant
rs1000592746 -- 35,489,501(+) AGTTT(C/T)CCCTG intron-variant
rs1001481896 -- 35,490,500(+) TTGCC(A/T)AGGAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTDAP Gene

Variant ID Type Subtype PubMed ID
nsv833811 CNV gain 17160897

Variation tolerance for KRTDAP Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTDAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTDAP Gene

Disorders for KRTDAP Gene

Relevant External Links for KRTDAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRTDAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTDAP Gene

Publications for KRTDAP Gene

  1. Characterization of Kdap, a protein secreted by keratinocytes. (PMID: 15140226) Tsuchida S. … Ariizumi K. (J. Invest. Dermatol. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Kdap, a novel gene associated with the stratification of the epithelium. (PMID: 11054531) Oomizu S. … Yoshizato K. (Gene 2000) 2 3 64
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3 64
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3 64

Products for KRTDAP Gene

Sources for KRTDAP Gene

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