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Aliases for RHOB Gene

Aliases for RHOB Gene

  • Ras Homolog Family Member B 2 3 5
  • Ras Homolog Gene Family, Member B 2 3
  • Rho CDNA Clone 6 3 4
  • Oncogene RHO H6 2 3
  • ARH6 3 4
  • ARHB 3 4
  • H6 3 4
  • Aplysia RAS-Related Homolog 6 3
  • MSTP081 3
  • MST081 3
  • RHOH6 3

External Ids for RHOB Gene

Previous HGNC Symbols for RHOB Gene

  • ARH6
  • ARHB

Previous GeneCards Identifiers for RHOB Gene

  • GC02P020632
  • GC02P020568
  • GC02P020510
  • GC02P020404
  • GC02P020646

Summaries for RHOB Gene

GeneCards Summary for RHOB Gene

RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include oculoauricular syndrome and sertoli cell-only syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOB Gene

  • Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Gene Wiki entry for RHOB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOB Gene

Genomics for RHOB Gene

Regulatory Elements for RHOB Gene

Promoters for RHOB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOB on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOB Gene

Chromosome:
2
Start:
20,447,071 bp from pter
End:
20,449,445 bp from pter
Size:
2,375 bases
Orientation:
Plus strand

Genomic View for RHOB Gene

Genes around RHOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOB Gene

Proteins for RHOB Gene

  • Protein details for RHOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62745-RHOB_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoB
    Protein Accession:
    P62745
    Secondary Accessions:
    • B2R692
    • P01121
    • Q5U0H6
    • Q7RTN5
    • Q7RTR9
    • Q9CUV7

    Protein attributes for RHOB Gene

    Size:
    196 amino acids
    Molecular mass:
    22123 Da
    Quaternary structure:
    • Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.
    Miscellaneous:
    • RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.

    Three dimensional structures from OCA and Proteopedia for RHOB Gene

neXtProt entry for RHOB Gene

Proteomics data for RHOB Gene at MOPED

Post-translational modifications for RHOB Gene

  • (Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RHOB (RHOB)

No data available for DME Specific Peptides for RHOB Gene

Domains & Families for RHOB Gene

Gene Families for RHOB Gene

Protein Domains for RHOB Gene

Suggested Antigen Peptide Sequences for RHOB Gene

Graphical View of Domain Structure for InterPro Entry

P62745

UniProtKB/Swiss-Prot:

RHOB_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOB: view

Function for RHOB Gene

Molecular function for RHOB Gene

UniProtKB/Swiss-Prot Function:
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).
genes like me logo Genes that share phenotypes with RHOB: view

Animal Models for RHOB Gene

MGI Knock Outs for RHOB:

Animal Model Products

  • Taconic Biosciences Mouse Models for RHOB

miRNA for RHOB Gene

miRTarBase miRNAs that target RHOB

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOB Gene

Localization for RHOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOB Gene

Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOB Gene COMPARTMENTS Subcellular localization image for RHOB gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with RHOB: view

Pathways & Interactions for RHOB Gene

genes like me logo Genes that share pathways with RHOB: view

SIGNOR curated interactions for RHOB Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16236794
GO:0006915 apoptotic process TAS 19637314
GO:0006927 transformed cell apoptotic process IEA,ISS --
GO:0007155 cell adhesion IEA,ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RHOB: view

Drugs & Compounds for RHOB Gene

(8) Drugs for RHOB Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Botulinum Toxin Type A Approved, Investigational Pharma Target 0

(11) Additional Compounds for RHOB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOB: view

Transcripts for RHOB Gene

mRNA/cDNA for RHOB Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(864) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOB Gene

Ras homolog family member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOB Gene

No ASD Table

Relevant External Links for RHOB Gene

GeneLoc Exon Structure for
RHOB
ECgene alternative splicing isoforms for
RHOB

Expression for RHOB Gene

mRNA expression in normal human tissues for RHOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOB Gene

This gene is overexpressed in Artery - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for RHOB Gene

This gene is overexpressed in Frontal cortex (21.9), Brain (19.9), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOB Gene



SOURCE GeneReport for Unigene cluster for RHOB Gene Hs.502876

genes like me logo Genes that share expression patterns with RHOB: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RHOB Gene

Orthologs for RHOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOB 35
  • 99.49 (n)
  • 100 (a)
RHOB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOB 36
  • 100 (a)
OneToOne
RHOB 35
  • 96.6 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RHOB 35
  • 96.77 (n)
  • 99.49 (a)
RHOB 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhob 16
Rhob 35
  • 94.9 (n)
  • 100 (a)
Rhob 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RHOB 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhob 35
  • 95.07 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RHOB 35
  • 90.31 (n)
  • 97.45 (a)
CRHOB 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOB 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhob 35
  • 84.69 (n)
  • 91.33 (a)
Str.7519 35
zebrafish
(Danio rerio)
Actinopterygii rhoac 36
  • 84 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rho1 36
  • 82 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 36
  • 80 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 36
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 36
  • 79 (a)
OneToMany
Species with no ortholog for RHOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOB Gene

ENSEMBL:
Gene Tree for RHOB (if available)
TreeFam:
Gene Tree for RHOB (if available)

Paralogs for RHOB Gene

genes like me logo Genes that share paralogs with RHOB: view

Variants for RHOB Gene

Sequence variations from dbSNP and Humsavar for RHOB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs585017 -- 20,446,871(+) AGCGC(A/G)GACTC upstream-variant-2KB
rs1062292 -- 20,448,450(+) TGTTC(G/T)CCCTT utr-variant-3-prime
rs2602160 -- 20,445,745(-) TGCAC(A/G)CCAGG upstream-variant-2KB
rs3088296 -- 20,449,441(-) ATTTT(A/T)TAAAT utr-variant-3-prime
rs7579125 -- 20,449,729(+) ATCTT(A/G)ATTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RHOB Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV Loss 17803354
nsv455830 CNV Loss 19166990
dgv4068n71 CNV Gain 21882294
dgv56n68 CNV Loss 17160897
nsv482049 CNV Gain 20164927

Variation tolerance for RHOB Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOB Gene

HapMap Linkage Disequilibrium report
RHOB
Human Gene Mutation Database (HGMD)
RHOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOB Gene

Disorders for RHOB Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOB Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
oculoauricular syndrome
  • schorderet-munier-franceschetti syndrome
sertoli cell-only syndrome
  • del castillo syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RHOB in MalaCards View complete list of genes associated with diseases

Relevant External Links for RHOB

Genetic Association Database (GAD)
RHOB
Human Genome Epidemiology (HuGE) Navigator
RHOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOB
genes like me logo Genes that share disorders with RHOB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOB Gene

Publications for RHOB Gene

  1. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P. … Tavitian A. (Nucleic Acids Res. 1988) 2 3 4 67
  2. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PMID: 16278215) Canguilhem B. … Favre G. (J. Biol. Chem. 2005) 2 3 23
  3. Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells. (PMID: 19995557) Kim C.H. … Chung K.S. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. (PMID: 19208833) Marlow L.A. … Copland J.A. (Cancer Res. 2009) 3 23
  5. Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. (PMID: 19477269) Hutchison N. … Sharpe C.C. (Cell. Signal. 2009) 3 23

Products for RHOB Gene

Sources for RHOB Gene

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