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Aliases for RHOB Gene

Aliases for RHOB Gene

  • Ras Homolog Family Member B 2 3
  • ARH6 3 4 6
  • ARHB 3 4 6
  • Ras Homolog Gene Family, Member B 2 3
  • Rho CDNA Clone 6 3 4
  • Oncogene RHO H6 2 3
  • RHOH6 3 6
  • H6 3 4
  • Rho-Related GTP-Binding Protein RhoB 3
  • Aplysia RAS-Related Homolog 6 3
  • MSTP081 3
  • MST081 3

External Ids for RHOB Gene

Previous Symbols for RHOB Gene

  • ARH6
  • ARHB

Summaries for RHOB Gene

GeneCards Summary for RHOB Gene

RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RHOB Gene

  • Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Gene Wiki entry for RHOB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOB Gene

Genomics for RHOB Gene

Genomic Location for RHOB Gene

Start:
20,447,074 bp from pter
End:
20,449,445 bp from pter
Size:
2,372 bases
Orientation:
Plus strand

Genomic View for RHOB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOB Gene

Regulatory Elements for RHOB Gene

Proteins for RHOB Gene

  • Protein details for RHOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62745-RHOB_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoB
    Protein Accession:
    P62745
    Secondary Accessions:
    • B2R692
    • P01121
    • Q5U0H6
    • Q7RTN5
    • Q7RTR9
    • Q9CUV7

    Protein attributes for RHOB Gene

    Size:
    196 amino acids
    Molecular mass:
    22123 Da
    Quaternary structure:
    • Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.
    Miscellaneous:
    • RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects

    Three dimensional structures from OCA and Proteopedia for RHOB Gene

neXtProt entry for RHOB Gene

Proteomics data for RHOB Gene at MOPED

Post-translational modifications for RHOB Gene

  • Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOB Gene

Domains for RHOB Gene

Protein Domains for RHOB Gene

Suggested Antigen Peptide Sequences for RHOB Gene

Graphical View of Domain Structure for InterPro Entry

P62745

UniProtKB/Swiss-Prot:

RHOB_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P62745
genes like me logo Genes that share domains with RHOB: view

No data available for Gene Families for RHOB Gene

Function for RHOB Gene

Molecular function for RHOB Gene

UniProtKB/Swiss-Prot Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
UniProtKB/Swiss-Prot Induction: Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).

Gene Ontology (GO) - Molecular Function for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 3888408
GO:0005515 protein binding IPI 19637314
GO:0005525 GTP binding TAS 1400319
GO:0019003 GDP binding IEA --
genes like me logo Genes that share ontologies with RHOB: view
genes like me logo Genes that share phenotypes with RHOB: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOB Gene

Localization for RHOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOB Gene

Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOB Gene COMPARTMENTS Subcellular localization image for RHOB gene
Compartment Confidence
endosome 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005769 early endosome IEA --
GO:0005770 late endosome --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOB: view

Pathways for RHOB Gene

genes like me logo Genes that share pathways with RHOB: view

Pathways by source for RHOB Gene

Gene Ontology (GO) - Biological Process for RHOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16236794
GO:0001525 angiogenesis IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IEA --
GO:0006915 apoptotic process TAS 19637314
genes like me logo Genes that share ontologies with RHOB: view

Compounds for RHOB Gene

(1) Drugbank Compounds for RHOB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Botulinum Toxin Type A
  • BoNT/A
93384-43-1 target

(18) Novoseek inferred chemical compound relationships for RHOB Gene

Compound -log(P) Hits PubMed IDs
azatyrosine 80.8 1
geranylgeranyl pyrophosphate 56.4 4
mevalonate 50.9 7
lovastatin 43.1 10
gtp 41.3 8
genes like me logo Genes that share compounds with RHOB: view

Transcripts for RHOB Gene

mRNA/cDNA for RHOB Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(864) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOB Gene

Ras homolog family member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOB Gene

No ASD Table

Relevant External Links for RHOB Gene

GeneLoc Exon Structure for
RHOB
ECgene alternative splicing isoforms for
RHOB

Expression for RHOB Gene

mRNA expression in normal human tissues for RHOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOB Gene

This gene is overexpressed in Artery - Tibial (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOB Gene

SOURCE GeneReport for Unigene cluster for RHOB Gene Hs.502876

genes like me logo Genes that share expressions with RHOB: view

No data available for mRNA Expression by UniProt/SwissProt for RHOB Gene

Orthologs for RHOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOB 35
  • 99.49 (n)
  • 100 (a)
RHOB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOB 35
  • 96.6 (n)
  • 100 (a)
RHOB 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOB 35
  • 96.77 (n)
  • 99.49 (a)
RHOB 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhob 35
  • 94.9 (n)
  • 100 (a)
Rhob 16
Rhob 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RHOB 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhob 35
  • 95.07 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves CRHOB 36
  • 97 (a)
OneToOne
RHOB 35
  • 90.31 (n)
  • 97.45 (a)
lizard
(Anolis carolinensis)
Reptilia RHOB 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhob 35
  • 84.69 (n)
  • 91.33 (a)
Str.7519 35
zebrafish
(Danio rerio)
Actinopterygii rhoac 36
  • 84 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rho1 36
  • 82 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rho-1 36
  • 80 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHO1 36
  • 60 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11308 36
  • 79 (a)
OneToMany
Species with no ortholog for RHOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOB Gene

ENSEMBL:
Gene Tree for RHOB (if available)
TreeFam:
Gene Tree for RHOB (if available)

Paralogs for RHOB Gene

Paralogs for RHOB Gene

genes like me logo Genes that share paralogs with RHOB: view

Variants for RHOB Gene

Sequence variations from dbSNP and Humsavar for RHOB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7043 -- 20,447,480(+) ATCCG(C/T)AAGAA reference, synonymous-codon
rs585017 -- 20,446,871(+) AGCGC(A/G)GACTC upstream-variant-2KB
rs1062149 -- 20,448,011(+) AAGCG(C/T)TACGG reference, synonymous-codon
rs1062192 -- 20,448,099(+) TCCCC(C/T)TCCTG utr-variant-3-prime
rs2602160 -- 20,445,745(-) TGCAC(A/G)CCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOB Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV Loss 17803354
nsv455830 CNV Loss 19166990
dgv4068n71 CNV Gain 21882294
dgv56n68 CNV Loss 17160897
nsv482049 CNV Gain 20164927

Relevant External Links for RHOB Gene

HapMap Linkage Disequilibrium report
RHOB
Human Gene Mutation Database (HGMD)
RHOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOB Gene

Disorders for RHOB Gene

(10) Novoseek inferred disease relationships for RHOB Gene

Disease -log(P) Hits PubMed IDs
tumors 30.6 25
cancer 25.8 10
cancer lung 21.3 14
neoplastic transformation 19.4 1
nsclc 14.9 6

Relevant External Links for RHOB

Genetic Association Database (GAD)
RHOB
Human Genome Epidemiology (HuGE) Navigator
RHOB
genes like me logo Genes that share disorders with RHOB: view

No data available for UniProtKB/Swiss-Prot for RHOB Gene

Publications for RHOB Gene

  1. PRK1 is targeted to endosomes by the small GTPase, RhoB. (PMID: 9478917) Mellor H. … Parker P.J. (J. Biol. Chem. 1998) 3 4 23
  2. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. (PMID: 7713879) Armstrong S.A. … Brown M.S. (J. Biol. Chem. 1995) 3 4 23
  3. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur W.T. … Wennerberg K. (J. Biol. Chem. 2002) 3 4 23
  4. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. (PMID: 16278215) Canguilhem B. … Favre G. (J. Biol. Chem. 2005) 2 3 23
  5. Coding sequence of human rho cDNAs clone 6 and clone 9. (PMID: 3283705) Chardin P. … Tavitian A. (Nucleic Acids Res. 1988) 2 3 4

Products for RHOB Gene

Sources for RHOB Gene

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