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Aliases for SLC22A10 Gene

Aliases for SLC22A10 Gene

  • Solute Carrier Family 22, Member 10 2 3
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 10 2 3
  • Organic Anion Transporter 5 3 4
  • OAT5 3 4
  • HOAT5 3

External Ids for SLC22A10 Gene

Previous GeneCards Identifiers for SLC22A10 Gene

  • GC11U990606
  • GC11P062815
  • GC11P059386
  • GC11P062905

Summaries for SLC22A10 Gene

GeneCards Summary for SLC22A10 Gene

SLC22A10 (Solute Carrier Family 22, Member 10) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A12.

Gene Wiki entry for SLC22A10 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A10 Gene

Genomics for SLC22A10 Gene

Regulatory Elements for SLC22A10 Gene

Genomic Location for SLC22A10 Gene

Chromosome:
11
Start:
63,137,867 bp from pter
End:
63,369,718 bp from pter
Size:
231,852 bases
Orientation:
Plus strand

Genomic View for SLC22A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SLC22A10 Gene

Proteins for SLC22A10 Gene

  • Protein details for SLC22A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63ZE4-S22AA_HUMAN
    Recommended name:
    Solute carrier family 22 member 10
    Protein Accession:
    Q63ZE4
    Secondary Accessions:
    • Q68CJ0

    Protein attributes for SLC22A10 Gene

    Size:
    541 amino acids
    Molecular mass:
    60257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A10 Gene

Proteomics data for SLC22A10 Gene at MOPED

Post-translational modifications for SLC22A10 Gene

  • Glycosylation at Asn 56 and Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A10 Gene

No data available for DME Specific Peptides for SLC22A10 Gene

Domains & Families for SLC22A10 Gene

Gene Families for SLC22A10 Gene

Protein Domains for SLC22A10 Gene

Suggested Antigen Peptide Sequences for SLC22A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q63ZE4

UniProtKB/Swiss-Prot:

S22AA_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A10: view

Function for SLC22A10 Gene

Gene Ontology (GO) - Molecular Function for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC22A10: view

Phenotypes for SLC22A10 Gene

GenomeRNAi human phenotypes for SLC22A10:
genes like me logo Genes that share phenotypes with SLC22A10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A10 Gene

Localization for SLC22A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A10 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Subcellular locations from COMPARTMENTS for SLC22A10 Gene

Pathways & Interactions for SLC22A10 Gene

SuperPathways for SLC22A10 Gene

No Data Available

Interacting Proteins for SLC22A10 Gene

Gene Ontology (GO) - Biological Process for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport --
GO:0098656 anion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A10 Gene

Drugs & Compounds for SLC22A10 Gene

(4) Drugs for SLC22A10 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Conjugated Estrogens Approved Pharma Transporter, inhibitor 0
Probenecid Approved Pharma Activator, Transporter, inhibitor 27
salicylic acid Approved Pharma Channel blocker, Transporter, inhibitor 136
Premarin Approved July of 2003 Pharma 0
genes like me logo Genes that share compounds with SLC22A10: view

Transcripts for SLC22A10 Gene

Unigene Clusters for SLC22A10 Gene

Solute carrier family 22, member 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:

Relevant External Links for SLC22A10 Gene

GeneLoc Exon Structure for
SLC22A10
ECgene alternative splicing isoforms for
SLC22A10

Expression for SLC22A10 Gene

mRNA expression in normal human tissues for SLC22A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A10 Gene

This gene is overexpressed in Liver (x43.0).

Protein differential expression in normal tissues from HIPED for SLC22A10 Gene

This gene is overexpressed in CD8 Tcells (45.7) and NK cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A10 Gene



SOURCE GeneReport for Unigene cluster for SLC22A10 Gene Hs.188982

mRNA Expression by UniProt/SwissProt for SLC22A10 Gene

Q63ZE4-S22AA_HUMAN
Tissue specificity: Detected in fetal and adult liver, and in adult kidney.
genes like me logo Genes that share expression patterns with SLC22A10: view

Protein tissue co-expression partners for SLC22A10 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC22A10 Gene

Orthologs for SLC22A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC522784 35
  • 79.31 (n)
  • 68.04 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC22A10 35
  • 79.75 (n)
  • 67.48 (a)
SLC22A10 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC22A10 35
  • 94.72 (n)
  • 93.28 (a)
SLC22A10 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Slc22a22 36
  • 38 (a)
ManyToMany
Species with no ortholog for SLC22A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A10 Gene

ENSEMBL:
Gene Tree for SLC22A10 (if available)
TreeFam:
Gene Tree for SLC22A10 (if available)

Paralogs for SLC22A10 Gene

Pseudogenes.org Pseudogenes for SLC22A10 Gene

genes like me logo Genes that share paralogs with SLC22A10: view

Variants for SLC22A10 Gene

Sequence variations from dbSNP and Humsavar for SLC22A10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473345 -- 63,305,559(-) tactc(A/G)agagg intron-variant
rs474096 -- 63,304,444(-) TGAGT(G/T)GTCCG intron-variant
rs474114 -- 63,284,471(+) CTGCA(A/G)Ttaaa intron-variant
rs474191 -- 63,305,490(-) accac(C/T)gcact intron-variant
rs474790 -- 63,294,953(-) agaaa(C/T)tcagg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC22A10 Gene

Variant ID Type Subtype PubMed ID
nsv897627 CNV Loss 21882294
dgv392e1 CNV Complex 17122850
nsv507596 CNV Insertion 20534489

Variation tolerance for SLC22A10 Gene

Residual Variation Intolerance Score: 96.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.47; 99.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A10 Gene

HapMap Linkage Disequilibrium report
SLC22A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A10 Gene

Disorders for SLC22A10 Gene

Relevant External Links for SLC22A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A10
genes like me logo Genes that share disorders with SLC22A10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A10 Gene

Publications for SLC22A10 Gene

  1. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W. … Erion M.D. (Biochem. Biophys. Res. Commun. 2001) 2 67
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 67
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 67
  5. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. (PMID: 15068970) Youngblood G.L. … Sweet D.H. (Am. J. Physiol. Renal Physiol. 2004) 25

Products for SLC22A10 Gene

Sources for SLC22A10 Gene

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