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Aliases for SUMO4 Gene

Aliases for SUMO4 Gene

  • Small Ubiquitin-Like Modifier 4 2 3 5
  • Insulin-Dependent Diabetes Mellitus 5 2 3
  • SMT3H4 3 4
  • SUMO-4 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (S. Cerevisiae) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (Yeast) 2
  • Small Ubiquitin-Like Modifier 4 Protein 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 3
  • Small Ubiquitin-Like Protein 4 4
  • DJ281H8.4 3
  • IDDM5 3

External Ids for SUMO4 Gene

Previous HGNC Symbols for SUMO4 Gene

  • SMT3H4
  • IDDM5

Previous GeneCards Identifiers for SUMO4 Gene

  • GC06U900642
  • GC0XM114776
  • GC06P149763
  • GC06P147288

Summaries for SUMO4 Gene

Entrez Gene Summary for SUMO4 Gene

  • This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO4 Gene

SUMO4 (Small Ubiquitin-Like Modifier 4) is a Protein Coding gene. Diseases associated with SUMO4 include Diabetes Mellitus, Insulin-Dependent, 5 and Erythema Infectiosum. Among its related pathways are RNA transport and HIF Repressor Pathways. An important paralog of this gene is SUMO1.

UniProtKB/Swiss-Prot for SUMO4 Gene

  • Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Gene Wiki entry for SUMO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO4 Gene

Genomics for SUMO4 Gene

Regulatory Elements for SUMO4 Gene

Enhancers for SUMO4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SUMO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUMO4 Gene

Chromosome:
6
Start:
149,400,227 bp from pter
End:
149,401,292 bp from pter
Size:
1,066 bases
Orientation:
Plus strand

Genomic View for SUMO4 Gene

Genes around SUMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO4 Gene

Proteins for SUMO4 Gene

  • Protein details for SUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EEV6-SUMO4_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 4
    Protein Accession:
    Q6EEV6
    Secondary Accessions:
    • A1L3W5

    Protein attributes for SUMO4 Gene

    Size:
    95 amino acids
    Molecular mass:
    10685 Da
    Quaternary structure:
    • Interacts with SAE2. Covalently attached to a number of proteins (Probable).

neXtProt entry for SUMO4 Gene

Proteomics data for SUMO4 Gene at MOPED

Post-translational modifications for SUMO4 Gene

  • In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SUMO4 Gene

Domains & Families for SUMO4 Gene

Protein Domains for SUMO4 Gene

Suggested Antigen Peptide Sequences for SUMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EEV6

UniProtKB/Swiss-Prot:

SUMO4_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the ubiquitin family. SUMO subfamily.
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO4: view

No data available for Gene Families for SUMO4 Gene

Function for SUMO4 Gene

Molecular function for SUMO4 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
genes like me logo Genes that share phenotypes with SUMO4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUMO4 Gene

Localization for SUMO4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO4 Gene COMPARTMENTS Subcellular localization image for SUMO4 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SUMO4 Gene

Pathways & Interactions for SUMO4 Gene

genes like me logo Genes that share pathways with SUMO4: view

Pathways by source for SUMO4 Gene

1 GeneTex pathway for SUMO4 Gene
1 KEGG pathway for SUMO4 Gene
2 R&D Systems pathways for SUMO4 Gene

Gene Ontology (GO) - Biological Process for SUMO4 Gene

None

No data available for SIGNOR curated interactions for SUMO4 Gene

Drugs & Compounds for SUMO4 Gene

(2) Drugs for SUMO4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SUMO4: view

Transcripts for SUMO4 Gene

mRNA/cDNA for SUMO4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUMO4 Gene

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO4 Gene

No ASD Table

Relevant External Links for SUMO4 Gene

GeneLoc Exon Structure for
SUMO4
ECgene alternative splicing isoforms for
SUMO4

Expression for SUMO4 Gene

mRNA expression in normal human tissues for SUMO4 Gene

Protein differential expression in normal tissues from HIPED for SUMO4 Gene

This gene is overexpressed in Skin (53.8), Heart (7.7), and Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUMO4 Gene



SOURCE GeneReport for Unigene cluster for SUMO4 Gene Hs.657168

mRNA Expression by UniProt/SwissProt for SUMO4 Gene

Q6EEV6-SUMO4_HUMAN
Tissue specificity: Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
genes like me logo Genes that share expression patterns with SUMO4: view

Protein tissue co-expression partners for SUMO4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SUMO4 Gene

Orthologs for SUMO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO4 35
  • 98.95 (n)
  • 97.89 (a)
-- 36
  • 39 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SUMO3 36
  • 74 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SUMO2 36
  • 85 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sumo3 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUMO2 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii sumo2b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta smt3 36
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 36
  • 62 (a)
OneToMany
Species with no ortholog for SUMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO4 Gene

ENSEMBL:
Gene Tree for SUMO4 (if available)
TreeFam:
Gene Tree for SUMO4 (if available)

Paralogs for SUMO4 Gene

Paralogs for SUMO4 Gene

(4) SIMAP similar genes for SUMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUMO4: view

Variants for SUMO4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO4 Gene

SUMO4_HUMAN-Q6EEV6
Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320].

Sequence variations from dbSNP and Humsavar for SUMO4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_023740 -

Structural Variations from Database of Genomic Variants (DGV) for SUMO4 Gene

Variant ID Type Subtype PubMed ID
nsv522875 CNV Loss 19592680

Variation tolerance for SUMO4 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO4 Gene

Human Gene Mutation Database (HGMD)
SUMO4

Disorders for SUMO4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SUMO4 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 5
erythema infectiosum
  • fifth disease
viral exanthem
diabetes mellitus, insulin-dependent
  • diabetes, type 1
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards
Search SUMO4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUMO4

Genetic Association Database (GAD)
SUMO4
Human Genome Epidemiology (HuGE) Navigator
SUMO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO4
genes like me logo Genes that share disorders with SUMO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO4 Gene

Publications for SUMO4 Gene

  1. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. (PMID: 15123604) Bohren K.M. … Owerbach D. (J. Biol. Chem. 2004) 2 3 4 23 48 67
  2. Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes. (PMID: 19956095) Podolsky R. … She J.X. (Genes Immun. 2009) 3 23
  3. A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes. (PMID: 17926234) Rudofsky G. … Hamann A. (Exp. Clin. Endocrinol. Diabetes 2008) 3 23
  4. SUMO4 and its role in type 1 diabetes pathogenesis. (PMID: 17990297) Wang C.Y. … She J.X. (Diabetes Metab. Res. Rev. 2008) 3 23
  5. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. (PMID: 17229939) Lin H.Y. … Shin S.J. (Diabetes 2007) 3 23

Products for SUMO4 Gene

Sources for SUMO4 Gene

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