Aliases for KRT16 Gene
External Ids for KRT16 Gene
Previous GeneCards Identifiers for KRT16 Gene
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT16 Gene
KRT16 (Keratin 16, Type I) is a Protein Coding gene. Diseases associated with KRT16 include pachyonychia congenita 1 and palmoplantar keratoderma, nonepidermolytic, focal. Among its related pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KRT34.
UniProtKB/Swiss-Prot for KRT16 Gene
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.