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Aliases for IL31 Gene

Aliases for IL31 Gene

  • Interleukin 31 2 3 5
  • IL-31 3 4

External Ids for IL31 Gene

Previous GeneCards Identifiers for IL31 Gene

  • GC00U914001
  • GC12U900495
  • GC12M121222
  • GC12M122656
  • GC12M119617

Summaries for IL31 Gene

Entrez Gene Summary for IL31 Gene

  • IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IL31 Gene

IL31 (Interleukin 31) is a Protein Coding gene. Diseases associated with IL31 include Dermatitis and Allergic Contact Dermatitis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL31 Gene

  • Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.

Gene Wiki entry for IL31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL31 Gene

Genomics for IL31 Gene

Regulatory Elements for IL31 Gene

Enhancers for IL31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL31 on UCSC Golden Path with GeneCards custom track

Promoters for IL31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL31 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL31 Gene

Chromosome:
12
Start:
122,172,030 bp from pter
End:
122,182,963 bp from pter
Size:
10,934 bases
Orientation:
Minus strand

Genomic View for IL31 Gene

Genes around IL31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL31 Gene

Proteins for IL31 Gene

  • Protein details for IL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EBC2-IL31_HUMAN
    Recommended name:
    Interleukin-31
    Protein Accession:
    Q6EBC2
    Secondary Accessions:
    • A2RUQ1

    Protein attributes for IL31 Gene

    Size:
    164 amino acids
    Molecular mass:
    18205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL31 Gene

Proteomics data for IL31 Gene at MOPED

Post-translational modifications for IL31 Gene

  • Glycosylation at Asn 67 and Asn 100

Other Protein References for IL31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL31

No data available for DME Specific Peptides for IL31 Gene

Domains & Families for IL31 Gene

Gene Families for IL31 Gene

Protein Domains for IL31 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL31: view

No data available for UniProtKB/Swiss-Prot for IL31 Gene

Function for IL31 Gene

Molecular function for IL31 Gene

UniProtKB/Swiss-Prot Function:
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).

Gene Ontology (GO) - Molecular Function for IL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with IL31: view

Phenotypes for IL31 Gene

GenomeRNAi human phenotypes for IL31:
genes like me logo Genes that share phenotypes with IL31: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL31 Gene

Localization for IL31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL31 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL31 Gene COMPARTMENTS Subcellular localization image for IL31 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with IL31: view

Pathways & Interactions for IL31 Gene

genes like me logo Genes that share pathways with IL31: view

Pathways by source for IL31 Gene

1 R&D Systems pathway for IL31 Gene

Interacting Proteins for IL31 Gene

SIGNOR curated interactions for IL31 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL31 Gene

None

Drugs & Compounds for IL31 Gene

(1) Drugs for IL31 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL31 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL31: view

Transcripts for IL31 Gene

mRNA/cDNA for IL31 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL31 Gene

Interleukin 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL31 Gene

No ASD Table

Relevant External Links for IL31 Gene

GeneLoc Exon Structure for
IL31
ECgene alternative splicing isoforms for
IL31

Expression for IL31 Gene

mRNA expression in normal human tissues for IL31 Gene

mRNA differential expression in normal tissues according to GTEx for IL31 Gene

This gene is overexpressed in Testis (x38.2), Muscle - Skeletal (x9.3), and Brain - Hypothalamus (x5.4).

SOURCE GeneReport for Unigene cluster for IL31 Gene Hs.569071

mRNA Expression by UniProt/SwissProt for IL31 Gene

Q6EBC2-IL31_HUMAN
Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
genes like me logo Genes that share expression patterns with IL31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL31 Gene

Orthologs for IL31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL31 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL31 35
  • 69.83 (n)
  • 55.06 (a)
IL-31 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL31 35
  • 98.37 (n)
  • 98.78 (a)
IL31 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il31 36
  • 28 (a)
OneToOne
Species with no ortholog for IL31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL31 Gene

ENSEMBL:
Gene Tree for IL31 (if available)
TreeFam:
Gene Tree for IL31 (if available)

Paralogs for IL31 Gene

No data available for Paralogs for IL31 Gene

Variants for IL31 Gene

Variation tolerance for IL31 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL31 Gene

Human Gene Mutation Database (HGMD)
IL31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IL31 Gene

Disorders for IL31 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL31 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dermatitis
  • eczema
allergic contact dermatitis
  • dermatitis allergic contact
atopic dermatitis
  • eczema
contact dermatitis
  • contact dermatitis nos
primary cutaneous amyloidosis
  • familial primary localized cutaneous amyloidosis
- elite association - COSMIC cancer census association via MalaCards
Search IL31 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL31

Genetic Association Database (GAD)
IL31
Human Genome Epidemiology (HuGE) Navigator
IL31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL31
genes like me logo Genes that share disorders with IL31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL31 Gene

Publications for IL31 Gene

  1. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PMID: 15184896) Dillon S.R. … Gross J.A. (Nat. Immunol. 2004) 2 3 4 67
  2. The histamine H4 receptor is functionally expressed on T(H)2 cells. (PMID: 19281909) Gutzmer R. … Werfel T. (J. Allergy Clin. Immunol. 2009) 3 23
  3. Regulated expression of the IL-31 receptor in bronchial and alveolar epithelial cells, pulmonary fibroblasts, and pulmonary macrophages. (PMID: 18439099) Jawa R.S. … Baumann H. (J. Interferon Cytokine Res. 2008) 3 23
  4. Structures and biological functions of IL-31 and IL-31 receptors. (PMID: 18926762) Zhang Q. … Gao W. (Cytokine Growth Factor Rev. 2008) 3 23
  5. Interleukin-31 stimulates production of inflammatory mediators from human colonic subepithelial myofibroblasts. (PMID: 17487427) Yagi Y. … Fujiyama Y. (Int. J. Mol. Med. 2007) 3 23

Products for IL31 Gene

Sources for IL31 Gene

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