Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT13 Gene

Aliases for KRT13 Gene

  • Keratin 13, Type I 2 3
  • Cytokeratin 13 2 3
  • Cytokeratin-13 3 4
  • Keratin-13 3 4
  • CK-13 3 4
  • K13 3 4
  • Type I Cytoskeletal 13 2
  • Keratin 13 2
  • Keratin 2
  • CK13 3
  • WSN2 3

External Ids for KRT13 Gene

Previous GeneCards Identifiers for KRT13 Gene

  • GC17M039241
  • GC17P041731
  • GC17M039565
  • GC17M040031
  • GC17M040033
  • GC17M036910
  • GC17M039657
  • GC17M035420

Summaries for KRT13 Gene

Entrez Gene Summary for KRT13 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT13 Gene

KRT13 (Keratin 13, Type I) is a Protein Coding gene. Diseases associated with KRT13 include white sponge nevus of cannon, krt13-related and white sponge nevus 2. Among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

Gene Wiki entry for KRT13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT13 Gene

Genomics for KRT13 Gene

Regulatory Elements for KRT13 Gene

Genomic Location for KRT13 Gene

41,500,981 bp from pter
41,505,705 bp from pter
4,725 bases
Minus strand

Genomic View for KRT13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT13 Gene

Proteins for KRT13 Gene

  • Protein details for KRT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 13
    Protein Accession:
    Secondary Accessions:
    • Q53G54
    • Q6AZK5
    • Q8N240

    Protein attributes for KRT13 Gene

    458 amino acids
    Molecular mass:
    49588 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)

    Alternative splice isoforms for KRT13 Gene


neXtProt entry for KRT13 Gene

Proteomics data for KRT13 Gene at MOPED

Post-translational modifications for KRT13 Gene

  • O-glycosylated; glycans consist of single N-acetylglucosamine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT13 Gene

No data available for DME Specific Peptides for KRT13 Gene

Domains & Families for KRT13 Gene

Gene Families for KRT13 Gene

Protein Domains for KRT13 Gene

Suggested Antigen Peptide Sequences for KRT13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT13: view

Function for KRT13 Gene

Molecular function for KRT13 Gene

GENATLAS Biochemistry:
keratin 13,major acidic keratin,type I,non cornifying mucosal epithelia (buccal,nasal,esophageal,anogenital)

Gene Ontology (GO) - Molecular Function for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KRT13: view
genes like me logo Genes that share phenotypes with KRT13: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT13 Gene

Localization for KRT13 Gene

Subcellular locations from

Jensen Localization Image for KRT13 Gene COMPARTMENTS Subcellular localization image for KRT13 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005882 intermediate filament --
GO:0045095 keratin filament IDA 9714826
GO:0045111 intermediate filament cytoskeleton IDA 21371075
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT13 Gene

Pathways & Interactions for KRT13 Gene

genes like me logo Genes that share pathways with KRT13: view

Pathways by source for KRT13 Gene

1 Cell Signaling Technology pathway for KRT13 Gene
1 GeneGo (Thomson Reuters) pathway for KRT13 Gene

Gene Ontology (GO) - Biological Process for KRT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IDA 21371075
GO:0009314 response to radiation IEA --
GO:0043587 tongue morphogenesis IEA --
GO:0071300 cellular response to retinoic acid IEA --
genes like me logo Genes that share ontologies with KRT13: view

No data available for SIGNOR curated interactions for KRT13 Gene

Drugs & Compounds for KRT13 Gene

(4) Drugs for KRT13 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Troglitazone Withdrawn Pharma Channel blocker Selective PPARgamma agonist; antidiabetic agent 7
vitamin d Pharma 1463
Calcium Nutra 0
proline Nutra 20

(5) Additional Compounds for KRT13 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
  • (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene
  • (E,E,E,E)-Squalene
  • 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • All-trans-Squalene
  • Nikko Squalane EX
  • Titanium alloy
  • Alpaste RTA 030
  • ATI 24
  • C.P. Titanium
  • Contimet 30
genes like me logo Genes that share compounds with KRT13: view

Transcripts for KRT13 Gene

Unigene Clusters for KRT13 Gene

Keratin 13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - -
SP4: -

Relevant External Links for KRT13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT13 Gene

mRNA expression in normal human tissues for KRT13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT13 Gene

This gene is overexpressed in Esophagus - Mucosa (x31.8), Vagina (x9.6), Cervix - Ectocervix (x5.9), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for KRT13 Gene

This gene is overexpressed in Saliva (29.6), Esophagus (29.2), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT13 Gene

SOURCE GeneReport for Unigene cluster for KRT13 Gene Hs.654550

mRNA Expression by UniProt/SwissProt for KRT13 Gene

Tissue specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
genes like me logo Genes that share expression patterns with KRT13: view

Protein tissue co-expression partners for KRT13 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for KRT13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT13 35
  • 89.23 (n)
  • 89.79 (a)
(Canis familiaris)
Mammalia KRT13 35
  • 91.9 (n)
  • 94.39 (a)
KRT13 36
  • 88 (a)
(Mus musculus)
Mammalia Krt13 35
  • 88.19 (n)
  • 91.89 (a)
Krt13 16
Krt13 36
  • 87 (a)
(Pan troglodytes)
Mammalia KRT13 35
  • 98.98 (n)
  • 100 (a)
KRT13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Krt13 35
  • 86.65 (n)
  • 90.48 (a)
(Monodelphis domestica)
Mammalia KRT13 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia KRT13 36
  • 79 (a)
(Gallus gallus)
Aves KRT15 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt15 35
  • 64.68 (n)
  • 64.18 (a)
Species with no ortholog for KRT13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT13 Gene

Gene Tree for KRT13 (if available)
Gene Tree for KRT13 (if available)

Paralogs for KRT13 Gene

genes like me logo Genes that share paralogs with KRT13: view

Variants for KRT13 Gene

Sequence variations from dbSNP and Humsavar for KRT13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs903 -- 41,501,085(+) CCGAC(A/C/T)GGAAG utr-variant-3-prime
rs1031 -- 41,501,099(-) CTCTG(G/T)GCTCT utr-variant-3-prime
rs736932 -- 41,504,489(+) AGACT(C/T)AGCCC intron-variant
rs760134 - 41,505,114(-) CCCAG(C/G)TAGCC reference, missense
rs1001378 -- 41,506,787(-) gtgtt(C/T)agcta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT13 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv483014 CNV Loss 15286789
dgv962e1 CNV Complex 17122850
nsv510711 CNV Loss 20534489
nsv526466 CNV Gain 19592680
nsv524606 CNV Loss 19592680
nsv9555 CNV Gain 18304495
nsv827992 CNV Gain 20364138
esv34903 CNV Gain 17911159

Variation tolerance for KRT13 Gene

Residual Variation Intolerance Score: 82.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT13 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT13 Gene

Disorders for KRT13 Gene

MalaCards: The human disease database

(24) MalaCards diseases for KRT13 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
white sponge nevus of cannon, krt13-related
  • hereditary mucosal leukokeratosis, krt13-related
white sponge nevus 2
  • wsn2
white sponge nevus 1
  • hereditary mucosal leukokeratosis
inverted papilloma
  • inverted papilloma, squamous cell
frontal sinus cancer
  • malignant tumor of the frontal sinus
- elite association
Search KRT13 in MalaCards View complete list of genes associated with diseases


  • White sponge nevus 2 (WSN2) [MIM:615785]: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. {ECO:0000269 PubMed:10561721, ECO:0000269 PubMed:11379896, ECO:0000269 PubMed:14600690, ECO:0000269 PubMed:7493031}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT13: view

No data available for Genatlas for KRT13 Gene

Publications for KRT13 Gene

  1. A new approach to the investigation of sexual offenses-cytoskeleton analysis reveals the origin of cells found on forensic swabs. (PMID: 20102457) Schulz M.M. … Wehner F. (J. Forensic Sci. 2010) 23 67
  2. Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas. (PMID: 20514438) Ohta K. … Kamata N. (Oncol. Rep. 2010) 23 67
  3. Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. (PMID: 20036603) Schaaij-Visser T.B. … Brakenhoff R.H. (Oral Oncol. 2010) 23 67
  4. Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. (PMID: 19956562) Jaworski C.J. … Wistow G. (Mol. Vis. 2009) 23 67
  5. [Immunofluorescence examination of CK-13 expression in cell line KB differentiated by all-trans retinoic acid or As2 O3]. (PMID: 19489262) Zhao X.H. … Zhang M. (Zhonghua Kou Qiang Yi Xue Za Zhi 2009) 23 67

Products for KRT13 Gene

Sources for KRT13 Gene

Back to Top