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Aliases for KRT6B Gene

Aliases for KRT6B Gene

  • Keratin 6B, Type II 2 3
  • Keratin-Like 1 (A Type II Keratin Sequence) 2 3
  • Type-II Keratin Kb10 3 4
  • Cytokeratin-6B 3 4
  • Keratin-6B 3 4
  • KRTL1 3 4
  • CK-6B 3 4
  • PC4 3 6
  • K6B 3 4
  • Keratin, Epidermal, Type II, K6B 3
  • Keratin, Type II Cytoskeletal 6B 3
  • Cytokeratin 6B 3
  • Keratin 6B 2
  • CK6B 3
  • PC2 3

External Ids for KRT6B Gene

Previous HGNC Symbols for KRT6B Gene

  • KRTL1

Previous GeneCards Identifiers for KRT6B Gene

  • GC12U990045
  • GC12M052870
  • GC12M052558
  • GC12M051126
  • GC12M052840
  • GC12M049884

Summaries for KRT6B Gene

Entrez Gene Summary for KRT6B Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT6B Gene

KRT6B (Keratin 6B, Type II) is a Protein Coding gene. Diseases associated with KRT6B include pachyonychia congenita 4 and pachyonychia congenita. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KRT82.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT6B Gene

Genomics for KRT6B Gene

Regulatory Elements for KRT6B Gene

Genomic Location for KRT6B Gene

52,446,651 bp from pter
52,452,126 bp from pter
5,476 bases
Minus strand

Genomic View for KRT6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT6B Gene

Proteins for KRT6B Gene

  • Protein details for KRT6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 6B
    Protein Accession:
    Secondary Accessions:
    • P48669

    Protein attributes for KRT6B Gene

    564 amino acids
    Molecular mass:
    60067 Da
    Quaternary structure:
    • Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17
    • There are at least six isoforms of human type II keratin-6 (K6)
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

neXtProt entry for KRT6B Gene

Proteomics data for KRT6B Gene at MOPED

Post-translational modifications for KRT6B Gene

  • Ubiquitination at Lys173, Lys180, and Lys252
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT6B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KRT6B (KRT6B)

No data available for DME Specific Peptides for KRT6B Gene

Domains for KRT6B Gene

Gene Families for KRT6B Gene

Protein Domains for KRT6B Gene

Suggested Antigen Peptide Sequences for KRT6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT6B: view

Function for KRT6B Gene

Molecular function for KRT6B Gene

GENATLAS Biochemistry:
keratin 6B,type II,upper outer hair root sheat,nail bed,palm and sole skin,suprabasal orogenital mucosal keratinocytes,dimerizing with KRT17

Gene Ontology (GO) - Molecular Function for KRT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton TAS 9618173
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT6B: view
genes like me logo Genes that share phenotypes with KRT6B: view

Animal Models for KRT6B Gene

MGI Knock Outs for KRT6B:

miRNA for KRT6B Gene

miRTarBase miRNAs that target KRT6B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT6B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KRT6B Gene

Localization for KRT6B Gene

Subcellular locations from

Jensen Localization Image for KRT6B Gene COMPARTMENTS Subcellular localization image for KRT6B gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT6B Gene

Pathways for KRT6B Gene

SuperPathways for KRT6B Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with KRT6B: view

Pathways by source for KRT6B Gene

1 Cell Signaling Technology pathway for KRT6B Gene

Gene Ontology (GO) - Biological Process for KRT6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007398 ectoderm development TAS 9618173
genes like me logo Genes that share ontologies with KRT6B: view

Drugs for KRT6B Gene

(1) Novoseek inferred chemical compound relationships for KRT6B Gene

Compound -log(P) Hits PubMed IDs
calcium 0 3
genes like me logo Genes that share compounds with KRT6B: view

Transcripts for KRT6B Gene

mRNA/cDNA for KRT6B Gene

(26) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT6B Gene

Keratin 6B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT6B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT6B Gene

No ASD Table

Relevant External Links for KRT6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT6B Gene

mRNA expression in normal human tissues for KRT6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT6B Gene

This gene is overexpressed in Esophagus - Mucosa (23.2), Skin - Not Sun Exposed (Suprapubic) (9.2), Cervix - Ectocervix (6.0), Minor Salivary Gland (5.3), Skin - Sun Exposed (Lower leg) (4.3), and Vagina (4.1).

Protein differential expression in normal tissues for KRT6B Gene

This gene is overexpressed in Urinary Bladder (36.1) and Saliva (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT6B Gene

SOURCE GeneReport for Unigene cluster for KRT6B Gene Hs.708950

mRNA Expression by UniProt/SwissProt for KRT6B Gene

Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath
genes like me logo Genes that share expressions with KRT6B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Expression partners for KRT6B Gene

Orthologs for KRT6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT6B Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Krt6a 35
  • 85.93 (n)
  • 87.5 (a)
Krt6b 16
Gm5414 36
  • 69 (a)
Krt6a 36
  • 87 (a)
Krt6b 36
  • 86 (a)
(Pan troglodytes)
Mammalia KRT6C 35
  • 99.23 (n)
  • 98.94 (a)
-- 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 86 (a)
KRT6B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
(Gallus gallus)
Aves KRT6A 36
  • 72 (a)
KRT75 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
Species with no ortholog for KRT6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT6B Gene

Gene Tree for KRT6B (if available)
Gene Tree for KRT6B (if available)

Paralogs for KRT6B Gene

genes like me logo Genes that share paralogs with KRT6B: view

Variants for KRT6B Gene

Sequence variations from dbSNP and Humsavar for KRT6B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs365763 -- 52,452,349(+) TGACT(C/T)GAGAT upstream-variant-2KB
rs373992 -- 52,446,252(-) CTCCC(C/T)GGCTC downstream-variant-500B
rs379695 -- 52,453,131(+) TAGAA(A/G)CTTAT upstream-variant-2KB
rs379961 -- 52,449,046(+) TCATG(A/C)ATGTC intron-variant
rs380379 -- 52,449,995(-) AAGCC(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT6B Gene

Variant ID Type Subtype PubMed ID
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897
nsv832412 CNV Loss 17160897
esv2751106 CNV Loss 17911159
nsv899090 CNV Loss 21882294
nsv899091 CNV Gain 21882294
esv7827 CNV Loss 19470904

Relevant External Links for KRT6B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT6B Gene

Disorders for KRT6B Gene

(1) OMIM Diseases for KRT6B Gene (148042)


  • Pachyonychia congenita 4 (PC4) [MIM:615728]: An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts. {ECO:0000269 PubMed:16250206, ECO:0000269 PubMed:21326300, ECO:0000269 PubMed:9618173}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(5) Novoseek inferred disease relationships for KRT6B Gene

Disease -log(P) Hits PubMed IDs
pachyonychia congenita, type 2 95.6 2
pachyonychia congenita, type 1 90.8 1
nail dystrophy 86.9 1
genetic disorder 38.7 1
tumors 0 1

Relevant External Links for KRT6B

genes like me logo Genes that share disorders with KRT6B: view

No data available for Genatlas for KRT6B Gene

Publications for KRT6B Gene

  1. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PMID: 1713141) Rosenberg M. … Shows T.B. (Cytogenet. Cell Genet. 1991) 2 3 23
  2. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. (PMID: 7543104) Takahashi K. … Coulombe P.A. (J. Biol. Chem. 1995) 3 4 23
  3. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. (PMID: 9618173) Smith F.J.D. … McLean W.H.I. (Hum. Mol. Genet. 1998) 3 4 23
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. The genetic basis of pachyonychia congenita. (PMID: 16250206) Smith F.J. … McLean W.H. (J. Investig. Dermatol. Symp. Proc. 2005) 4 23

Products for KRT6B Gene

Sources for KRT6B Gene

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