Aliases for ARG2 Gene
External Ids for ARG2 Gene
Previous GeneCards Identifiers for ARG2 Gene
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARG2 Gene
ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include Exudative Vitreoretinopathy 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Arginine biosynthesis. GO annotations related to this gene include arginase activity. An important paralog of this gene is ARG1.
UniProtKB/Swiss-Prot for ARG2 Gene
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.