Aliases for ARG1 Gene
External Ids for ARG1 Gene
Previous GeneCards Identifiers for ARG1 Gene
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for ARG1 Gene
ARG1 (Arginase 1) is a Protein Coding gene. Diseases associated with ARG1 include argininemia and blue toe syndrome. Among its related pathways are Metabolism and NgR-p75(NTR)-Mediated Signaling. GO annotations related to this gene include manganese ion binding and arginase activity. An important paralog of this gene is ARG2.