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Aliases for ARG1 Gene

Aliases for ARG1 Gene

  • Arginase 1 2 3
  • EC 4 63
  • Liver-Type Arginase 4
  • Arginase, Liver 2
  • Type I Arginase 4

External Ids for ARG1 Gene

Previous GeneCards Identifiers for ARG1 Gene

  • GC06P131741
  • GC06P131874
  • GC06P131936
  • GC06P129475

Summaries for ARG1 Gene

Entrez Gene Summary for ARG1 Gene

  • Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARG1 Gene

ARG1 (Arginase 1) is a Protein Coding gene. Diseases associated with ARG1 include argininemia and blue toe syndrome. Among its related pathways are Metabolism and NgR-p75(NTR)-Mediated Signaling. GO annotations related to this gene include manganese ion binding and arginase activity. An important paralog of this gene is ARG2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARG1 Gene

Genomics for ARG1 Gene

Regulatory Elements for ARG1 Gene

Genomic Location for ARG1 Gene

131,573,144 bp from pter
131,584,332 bp from pter
11,189 bases
Plus strand

Genomic View for ARG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARG1 Gene

Proteins for ARG1 Gene

  • Protein details for ARG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NEA0
    • Q5JWT5
    • Q5JWT6
    • Q8TE72
    • Q9BS50

    Protein attributes for ARG1 Gene

    322 amino acids
    Molecular mass:
    34735 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for ARG1 Gene

    Alternative splice isoforms for ARG1 Gene


neXtProt entry for ARG1 Gene

Proteomics data for ARG1 Gene at MOPED

Selected DME Specific Peptides for ARG1 Gene

Post-translational modifications for ARG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ARG1 (Arginase 1/ARG1)
  • Cell Signaling Technology (CST) Antibodies for ARG1 (ARG1)

Domains & Families for ARG1 Gene

Gene Families for ARG1 Gene


Suggested Antigen Peptide Sequences for ARG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arginase family.
  • Belongs to the arginase family.
genes like me logo Genes that share domains with ARG1: view

Function for ARG1 Gene

Molecular function for ARG1 Gene

GENATLAS Biochemistry:
arginase,liver,ornithine metabolism,urea cycle,cytoplasmic
UniProtKB/Swiss-Prot CatalyticActivity:
L-arginine + H(2)O = L-ornithine + urea
UniProtKB/Swiss-Prot Induction:
By arginine or homoarginine

Enzyme Numbers (IUBMB) for ARG1 Gene

Gene Ontology (GO) - Molecular Function for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004053 arginase activity EXP --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines --
GO:0030145 manganese ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ARG1: view
genes like me logo Genes that share phenotypes with ARG1: view

Animal Models for ARG1 Gene

MGI Knock Outs for ARG1:

Animal Model Products

miRNA for ARG1 Gene

miRTarBase miRNAs that target ARG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARG1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ARG1 Gene

Localization for ARG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARG1 Gene


Subcellular locations from

Jensen Localization Image for ARG1 Gene COMPARTMENTS Subcellular localization image for ARG1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm TAS 3540966
GO:0005741 mitochondrial outer membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARG1: view

Pathways & Interactions for ARG1 Gene

genes like me logo Genes that share pathways with ARG1: view

PCR Array Products

UniProtKB/Swiss-Prot P05089-ARGI1_HUMAN

  • Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1

Gene Ontology (GO) - Biological Process for ARG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
GO:0001889 liver development IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0006525 arginine metabolic process --
GO:0006527 arginine catabolic process TAS 3540966
genes like me logo Genes that share ontologies with ARG1: view

No data available for SIGNOR curated interactions for ARG1 Gene

Drugs & Compounds for ARG1 Gene

(29) Drugs for ARG1 Gene - From: NovoSeek, DrugBank, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Full agonist, Agonist, Target 31
L-Arginine Approved Nutra Full agonist, Agonist 0
Nitric Oxide Approved Pharma 540
Citrulline Approved Nutra Full agonist, Agonist 0
Urea Experimental Pharma Target 0

(11) Additional Compounds for ARG1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
Carbamoyl phosphate
  • Carbamic acid monoanhydride with phosphorate
  • Carbamic acid monoanhydride with phosphoric acid
  • Carbamoyl-P
  • Carbamoyl-phosphate
  • Carbamoylphosphate
diethyl pyrocarbonate
genes like me logo Genes that share compounds with ARG1: view

Transcripts for ARG1 Gene

Unigene Clusters for ARG1 Gene

Arginase, liver:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARG1 Gene

No ASD Table

Relevant External Links for ARG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARG1 Gene

mRNA expression in normal human tissues for ARG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARG1 Gene

This gene is overexpressed in Liver (x28.1) and Whole Blood (x17.7).

Protein differential expression in normal tissues from HIPED for ARG1 Gene

This gene is overexpressed in Liver, secretome (40.5) and Liver (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARG1 Gene

SOURCE GeneReport for Unigene cluster for ARG1 Gene Hs.440934

genes like me logo Genes that share expression patterns with ARG1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARG1 Gene

Orthologs for ARG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARG1 35
  • 89.34 (n)
  • 90.99 (a)
ARG1 36
  • 91 (a)
(Canis familiaris)
Mammalia ARG1 35
  • 90.2 (n)
  • 91.52 (a)
ARG1 36
  • 91 (a)
(Mus musculus)
Mammalia Arg1 35
  • 83.13 (n)
  • 86.96 (a)
Arg1 16
Arg1 36
  • 86 (a)
(Pan troglodytes)
Mammalia ARG1 35
  • 99.38 (n)
  • 99.38 (a)
ARG1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Arg1 35
  • 82.71 (n)
  • 87.27 (a)
(Monodelphis domestica)
Mammalia ARG1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia ARG1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arg1 35
  • 68.8 (n)
  • 71.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia arg1-prov 35
(Danio rerio)
Actinopterygii arg1 35
  • 64.54 (n)
  • 62.94 (a)
arg1 36
  • 57 (a)
ARG1 (1 of 2) 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta arg 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR225C 35
  • 46.69 (n)
  • 45.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00704g 35
  • 48.73 (n)
  • 44.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAR1 35
  • 48.22 (n)
  • 43.69 (a)
CAR1 36
  • 40 (a)
CAR1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02333 35
  • 50.89 (n)
  • 49.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes car1 35
  • 49.14 (n)
  • 44.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8475 36
  • 42 (a)
Species with no ortholog for ARG1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARG1 Gene

Gene Tree for ARG1 (if available)
Gene Tree for ARG1 (if available)

Paralogs for ARG1 Gene

Paralogs for ARG1 Gene

(1) SIMAP similar genes for ARG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARG1: view

Variants for ARG1 Gene

Sequence variations from dbSNP and Humsavar for ARG1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs376196920 -- 131,573,431(+) GTTCA(A/G)TTTTC intron-variant
rs374252439 -- 131,571,402(+) TAAAA(A/G)GTAAA upstream-variant-2KB
rs374231313 -- 131,573,376(+) GAATT(C/T)AGTTG intron-variant
rs372027494 -- 131,571,697(+) GATAA(A/G)CTCTA upstream-variant-2KB
rs371441530 -- 131,571,457(+) AATGA(C/T)AAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARG1 Gene

Variant ID Type Subtype PubMed ID
nsv886668 CNV Gain 21882294

Variation tolerance for ARG1 Gene

Residual Variation Intolerance Score: 35.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARG1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARG1 Gene

Disorders for ARG1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for ARG1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
  • hyperargininemia
blue toe syndrome
recessive dystrophic epidermolysis bullosa
  • rdeb
central nervous system tuberculosis
  • tuberculoma of brain
cholesterol embolism
  • warfarin blue toe syndrome
- elite association
Search ARG1 in MalaCards View complete list of genes associated with diseases


  • Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269 PubMed:1463019, ECO:0000269 PubMed:22959135, ECO:0000269 PubMed:23859858, ECO:0000269 PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for ARG1 Gene

argininemia,with progressive spastic quadriplegia and mental retardation

Relevant External Links for ARG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARG1: view

Publications for ARG1 Gene

  1. Arginine availability, arginase, and the immune response. (PMID: 12589193) Bansal V. … Ochoa J.B. (Curr Opin Clin Nutr Metab Care 2003) 23 25 26 67
  2. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. (PMID: 11971019) Gobert A.P. … Wilson K.T. (J. Immunol. 2002) 25 26 67
  3. Analysis of novel ARG1 mutations causing hyperargininemia and correlation with arginase I activity in erythrocytes. (PMID: 22959135) Carvalho D.R. … Pratesi R. (Gene 2012) 2 67
  4. Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism. (PMID: 20032293) Yachimovich-Cohen N. … Reubinoff B. (J. Immunol. 2010) 23 67
  5. Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. (PMID: 20124949) Vonk J.M. … Meurs H. (Pharmacogenet. Genomics 2010) 23 67

Products for ARG1 Gene

Sources for ARG1 Gene

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