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Aliases for KLRD1 Gene

Aliases for KLRD1 Gene

  • Killer Cell Lectin-Like Receptor Subfamily D, Member 1 2 3
  • CD94 3 4 6
  • NK Cell Receptor 3 4
  • CD94 Antigen 3 4
  • KP43 3 4
  • Killer Cell Lectin-Like Receptor Subfamily D Member 1 4
  • Natural Killer Cells Antigen CD94 3

External Ids for KLRD1 Gene

Previous Symbols for KLRD1 Gene

  • CD94

Summaries for KLRD1 Gene

Entrez Gene Summary for KLRD1 Gene

  • Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRD1 Gene

KLRD1 (Killer Cell Lectin-Like Receptor Subfamily D, Member 1) is a Protein Coding gene. Diseases associated with KLRD1 include t-cell large granular lymphocyte leukemia. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRC1.

UniProtKB/Swiss-Prot for KLRD1 Gene

  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

Gene Wiki entry for KLRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRD1 Gene

Genomics for KLRD1 Gene

Genomic Location for KLRD1 Gene

Start:
10,226,058 bp from pter
End:
10,360,833 bp from pter
Size:
134,776 bases
Orientation:
Plus strand

Genomic View for KLRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRD1 Gene

Regulatory Elements for KLRD1 Gene

Proteins for KLRD1 Gene

  • Protein details for KLRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13241-KLRD1_HUMAN
    Recommended name:
    Natural killer cells antigen CD94
    Protein Accession:
    Q13241
    Secondary Accessions:
    • O43321
    • O43773
    • Q9UBE3
    • Q9UEQ0

    Protein attributes for KLRD1 Gene

    Size:
    179 amino acids
    Molecular mass:
    20513 Da
    Quaternary structure:
    • Can form disulfide-bonded heterodimer with NKG2 family members.

    Three dimensional structures from OCA and Proteopedia for KLRD1 Gene

    Alternative splice isoforms for KLRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLRD1 Gene

Proteomics data for KLRD1 Gene at MOPED

Post-translational modifications for KLRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn83 and Asn132

No data available for DME Specific Peptides for KLRD1 Gene

Domains for KLRD1 Gene

Gene Families for KLRD1 Gene

HGNC:
  • CD :CD molecules
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13241

UniProtKB/Swiss-Prot:

KLRD1_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q13241
genes like me logo Genes that share domains with KLRD1: view

Function for KLRD1 Gene

Molecular function for KLRD1 Gene

GENATLAS Biochemistry: natural killer cell lectin-like receptor subfamily D,member 1
UniProtKB/Swiss-Prot Function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells

Gene Ontology (GO) - Molecular Function for KLRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 7589107
GO:0005515 protein binding IPI 18448674
GO:0023024 MHC class I protein complex binding IPI 18448674
GO:0023030 MHC class Ib protein binding, via antigen binding groove IPI 25631937
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRD1: view

Phenotypes for KLRD1 Gene

MGI mutant phenotypes for KLRD1:
inferred from 2 alleles
GenomeRNAi human phenotypes for KLRD1:
genes like me logo Genes that share phenotypes with KLRD1: view

Animal Models for KLRD1 Gene

MGI Knock Outs for KLRD1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KLRD1 Gene

Localization for KLRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRD1 Gene COMPARTMENTS Subcellular localization image for KLRD1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for KLRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 18448674
genes like me logo Genes that share ontologies with KLRD1: view

Pathways for KLRD1 Gene

genes like me logo Genes that share pathways with KLRD1: view

Gene Ontology (GO) - Biological Process for KLRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002228 natural killer cell mediated immunity IDA 18448674
GO:0007166 cell surface receptor signaling pathway TAS 7589107
GO:0045087 innate immune response TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with KLRD1: view

Compounds for KLRD1 Gene

(2) Novoseek inferred chemical compound relationships for KLRD1 Gene

Compound -log(P) Hits PubMed IDs
toxin-1 50.4 1
tyrosine 0.101 3
genes like me logo Genes that share compounds with KLRD1: view

Transcripts for KLRD1 Gene

Unigene Clusters for KLRD1 Gene

Killer cell lectin-like receptor subfamily D, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for KLRD1 Gene

GeneLoc Exon Structure for
KLRD1
ECgene alternative splicing isoforms for
KLRD1

Expression for KLRD1 Gene

mRNA expression in normal human tissues for KLRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRD1 Gene

This gene is overexpressed in Whole Blood (28.5) and Spleen (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLRD1 Gene

SOURCE GeneReport for Unigene cluster for KLRD1 Gene Hs.562457

mRNA Expression by UniProt/SwissProt for KLRD1 Gene

Q13241-KLRD1_HUMAN
Tissue specificity: Natural killer cells
genes like me logo Genes that share expressions with KLRD1: view

Orthologs for KLRD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRD1 35
  • 99.63 (n)
  • 99.44 (a)
KLRD1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
KLRD1 35
  • 75.81 (n)
  • 65.71 (a)
KLRD1 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KLRD1 35
  • 76.91 (n)
  • 59.78 (a)
KLRD1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klrd1 35
  • 71.78 (n)
  • 54.55 (a)
Klrd1 16
Klrd1 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
-- 36
  • 22 (a)
OneToMany
-- 36
  • 20 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
-- 36
  • 18 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Klrd1 35
  • 70.45 (n)
  • 55.11 (a)
Species with no ortholog for KLRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRD1 Gene

ENSEMBL:
Gene Tree for KLRD1 (if available)
TreeFam:
Gene Tree for KLRD1 (if available)

Paralogs for KLRD1 Gene

Paralogs for KLRD1 Gene

genes like me logo Genes that share paralogs with KLRD1: view

Variants for KLRD1 Gene

Sequence variations from dbSNP and Humsavar for KLRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1478305 -- 10,330,784(-) AGCTC(A/G)TACAG intron-variant
rs1600126 -- 10,317,430(+) ccatg(G/T)gctaa downstream-variant-500B, intron-variant
rs1817390 -- 10,354,040(+) ATGTT(G/T)GTGTG intron-variant
rs1947763 -- 10,357,317(+) catat(A/G)catat intron-variant
rs1947764 -- 10,357,602(+) acgag(A/G)cattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLRD1 Gene

Variant ID Type Subtype PubMed ID
nsv898757 CNV Gain 21882294
nsv832328 CNV Gain 17160897
nsv605 CNV Loss 18451855
nsv898759 CNV Loss 21882294

Relevant External Links for KLRD1 Gene

HapMap Linkage Disequilibrium report
KLRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRD1 Gene

Disorders for KLRD1 Gene

(12) Novoseek inferred disease relationships for KLRD1 Gene

Disease -log(P) Hits PubMed IDs
toxic shock syndrome 38.9 1
psoriasis 37.1 2
genetic susceptibility 12.8 1
lymphoma t-cell 11.7 3
tumors 8.24 2

Relevant External Links for KLRD1

Genetic Association Database (GAD)
KLRD1
Human Genome Epidemiology (HuGE) Navigator
KLRD1
genes like me logo Genes that share disorders with KLRD1: view

No data available for UniProtKB/Swiss-Prot for KLRD1 Gene

Publications for KLRD1 Gene

  1. Structure of the human CD94 C-type lectin gene. (PMID: 9472066) Rodriguez A. … Lopez-Botet M. (Immunogenetics 1998) 3 4 23
  2. Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. (PMID: 10023772) Boyington J.C. … Sun P.D. (Immunity 1999) 3 4 23
  3. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. (PMID: 12618865) Hikami K. … Tokunaga K. (Genes Immun. 2003) 3 23 48
  4. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. (PMID: 7589107) Chang C. … Lanier L.L. (Eur. J. Immunol. 1995) 2 3 4
  5. NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid. (PMID: 19303396) Imaizumi Y. … Matsumoto K. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for KLRD1 Gene

Sources for KLRD1 Gene

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