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Aliases for KLRB1 Gene

Aliases for KLRB1 Gene

  • Killer Cell Lectin-Like Receptor Subfamily B, Member 1 2 3
  • NKRP1A 3 4 6
  • Natural Killer Cell Surface Protein P1A 3 4
  • C-Type Lectin Domain Family 5 Member B 3 4
  • HNKR-P1A 3 4
  • NKR-P1A 3 4
  • CLEC5B 3 4
  • Killer Cell Lectin-Like Receptor Subfamily B Member 1 3
  • CD161 Antigen 4
  • NKR-P1 3
  • CD161 3
  • NKR 3

External Ids for KLRB1 Gene

Previous Symbols for KLRB1 Gene

  • NKR

Summaries for KLRB1 Gene

Entrez Gene Summary for KLRB1 Gene

  • Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLRB1 Gene

KLRB1 (Killer Cell Lectin-Like Receptor Subfamily B, Member 1) is a Protein Coding gene. Diseases associated with KLRB1 include cytomegalovirus infection. Among its related pathways are Malaria. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is KLRF2.

UniProtKB/Swiss-Prot for KLRB1 Gene

  • Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Gene Wiki entry for KLRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRB1 Gene

Genomics for KLRB1 Gene

Genomic Location for KLRB1 Gene

Start:
9,594,551 bp from pter
End:
9,607,901 bp from pter
Size:
13,351 bases
Orientation:
Minus strand

Genomic View for KLRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLRB1 Gene

Regulatory Elements for KLRB1 Gene

Proteins for KLRB1 Gene

  • Protein details for KLRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12918-KLRB1_HUMAN
    Recommended name:
    Killer cell lectin-like receptor subfamily B member 1
    Protein Accession:
    Q12918
    Secondary Accessions:
    • Q24K24

    Protein attributes for KLRB1 Gene

    Size:
    225 amino acids
    Molecular mass:
    25415 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.

neXtProt entry for KLRB1 Gene

Proteomics data for KLRB1 Gene at MOPED

Post-translational modifications for KLRB1 Gene

Other Protein References for KLRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLRB1 Gene

Domains for KLRB1 Gene

Gene Families for KLRB1 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing
  • KLR :Killer cell lectin-like receptors

Protein Domains for KLRB1 Gene

UniProtKB/Swiss-Prot:

KLRB1_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q12918
genes like me logo Genes that share domains with KLRB1: view

Function for KLRB1 Gene

Molecular function for KLRB1 Gene

GENATLAS Biochemistry: natural killer cell lectin-like receptor subfamily B,member 1
UniProtKB/Swiss-Prot Function: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
UniProtKB/Swiss-Prot Induction: By IL12/interleukin-12 in NK cells.

Gene Ontology (GO) - Molecular Function for KLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8077657
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with KLRB1: view

Phenotypes for KLRB1 Gene

GenomeRNAi human phenotypes for KLRB1:
genes like me logo Genes that share phenotypes with KLRB1: view

miRNA for KLRB1 Gene

miRTarBase miRNAs that target KLRB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLRB1 Gene

Localization for KLRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLRB1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLRB1 Gene COMPARTMENTS Subcellular localization image for KLRB1 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for KLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 8077657
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLRB1: view

Pathways for KLRB1 Gene

SuperPathways for KLRB1 Gene

Superpath Contained pathways
1 Malaria
genes like me logo Genes that share pathways with KLRB1: view

Pathways by source for KLRB1 Gene

1 KEGG pathway for KLRB1 Gene

Interacting Proteins for KLRB1 Gene

Gene Ontology (GO) - Biological Process for KLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 8077657
genes like me logo Genes that share ontologies with KLRB1: view

Compounds for KLRB1 Gene

(111) HMDB Compounds for KLRB1 Gene

Compound Synonyms Cas Number PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • Sulfatide (d18:1/18:1(9Z))
Not Available

(3) Novoseek inferred chemical compound relationships for KLRB1 Gene

Compound -log(P) Hits PubMed IDs
alpha-galactosylceramide 66.7 1
calcium 0 2
tyrosine 0 1
genes like me logo Genes that share compounds with KLRB1: view

Transcripts for KLRB1 Gene

mRNA/cDNA for KLRB1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLRB1 Gene

Killer cell lectin-like receptor subfamily B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLRB1 Gene

No ASD Table

Relevant External Links for KLRB1 Gene

GeneLoc Exon Structure for
KLRB1
ECgene alternative splicing isoforms for
KLRB1

Expression for KLRB1 Gene

mRNA expression in normal human tissues for KLRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLRB1 Gene

This gene is overexpressed in Whole Blood (23.4), Spleen (8.3), and Small Intestine - Terminal Ileum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KLRB1 Gene

SOURCE GeneReport for Unigene cluster for KLRB1 Gene Hs.169824

mRNA Expression by UniProt/SwissProt for KLRB1 Gene

Q12918-KLRB1_HUMAN
Tissue specificity: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
genes like me logo Genes that share expressions with KLRB1: view

Orthologs for KLRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLRB1 36
  • 99.26 (n)
  • 98.67 (a)
KLRB1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLRB1 36
  • 76.47 (n)
  • 62.03 (a)
KLRB1 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLRB1 36
  • 76.92 (n)
  • 63.8 (a)
KLRB1 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klrb1 16
Klrb1 37
  • 49 (a)
OneToMany
Klrb1a 36
  • 66.36 (n)
  • 48.6 (a)
Klrb1a 37
  • 45 (a)
OneToMany
Klrb1b 37
  • 44 (a)
OneToMany
Klrb1c 37
  • 38 (a)
OneToMany
Klrb1f 37
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Klrb1a 36
  • 67.57 (n)
  • 49.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 26 (a)
OneToMany
-- 37
  • 25 (a)
OneToMany
-- 37
  • 26 (a)
OneToMany
Species with no ortholog for KLRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLRB1 Gene

ENSEMBL:
Gene Tree for KLRB1 (if available)
TreeFam:
Gene Tree for KLRB1 (if available)

Paralogs for KLRB1 Gene

Paralogs for KLRB1 Gene

Selected SIMAP similar genes for KLRB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLRB1: view

Variants for KLRB1 Gene

Sequence variations from dbSNP and Humsavar for KLRB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs985911 -- 9,597,130(-) ATTAT(A/C)CTAAG intron-variant
rs985912 -- 9,597,086(-) GAAAG(A/G)AATGT intron-variant
rs985913 -- 9,596,947(-) ACATA(C/T)ACATT intron-variant
rs988711 -- 9,605,744(-) AATGA(C/T)AGTAA intron-variant
rs1135816 - 9,598,073(+) CGTTT(A/G)TCCAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KLRB1 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
nsv428271 CNV Gain 18775914
dgv468e1 CNV Complex 17122850
nsv602 CNV Loss 18451855
dgv469e1 CNV Complex 17122850
dgv471e1 CNV Complex 17122850
dgv1369n71 CNV Loss 21882294
nsv898754 CNV Loss 21882294
essv5635 CNV CNV 17122850
essv6453 CNV CNV 17122850
nsv8909 CNV Gain 18304495
esv260059 OTHER Complex 20981092
nsv603 CNV Insertion 18451855

Relevant External Links for KLRB1 Gene

HapMap Linkage Disequilibrium report
KLRB1

Disorders for KLRB1 Gene

(6) Novoseek inferred disease relationships for KLRB1 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 31.4 1
autoimmune diseases 21 2
tumors 0 6
lymphoma 0 2
melanoma 0 2

Relevant External Links for KLRB1

Genetic Association Database (GAD)
KLRB1
Human Genome Epidemiology (HuGE) Navigator
KLRB1
genes like me logo Genes that share disorders with KLRB1: view

No data available for UniProtKB/Swiss-Prot for KLRB1 Gene

Publications for KLRB1 Gene

  1. Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. (PMID: 8077657) Lanier L.L. … Phillips J.H. (J. Immunol. 1994) 2 3 4 23
  2. Lectin-like transcript 1 is a ligand for the CD161 receptor. (PMID: 16339512) Aldemir H. … Braud V.M. (J. Immunol. 2005) 3 4 23
  3. IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation. (PMID: 9603467) Poggi A. … Moretta L. (Eur. J. Immunol. 1998) 3 4 23
  4. Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161). (PMID: 16925668) Christiansen D. … Sandrin M.S. (Xenotransplantation 2006) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLRB1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Surface Markers in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KLRB1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KLRB1
    • Block miRNA regulation of KLRB1 using miScript Target Protectors
    • antibodies-online proteins for KLRB1
    • antibodies-online antibodies for KLRB1
    • antibodies-online kits for KLRB1

    Sources for KLRB1 Gene

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