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Aliases for ARF6 Gene

Subcategory (RNA class) for ARF6 Gene

lncRNA

Aliases for ARF6 Gene

  • ADP-Ribosylation Factor 6 2 3

External Ids for ARF6 Gene

ORGUL Members for ARF6 Gene

Previous GeneCards Identifiers for ARF6 Gene

  • GC14P047681
  • GC14P044155
  • GC14P048349
  • GC14P049429
  • GC14P050359
  • GC14P030484

Summaries for ARF6 Gene

Entrez Gene Summary for ARF6 Gene

  • This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF6 Gene

ARF6 (ADP-Ribosylation Factor 6) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with ARF6 include cholera. Among its related pathways are Ras signaling pathway and GPCR Pathway. GO annotations related to this gene include GTP binding and thioesterase binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF6 Gene

  • GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Gene Wiki entry for ARF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF6 Gene

Genomics for ARF6 Gene

Regulatory Elements for ARF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARF6 Gene

Start:
49,893,018 bp from pter
End:
49,897,054 bp from pter
Size:
4,037 bases
Orientation:
Plus strand

Genomic View for ARF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF6 Gene

Proteins for ARF6 Gene

  • Protein details for ARF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62330-ARF6_HUMAN
    Recommended name:
    ADP-ribosylation factor 6
    Protein Accession:
    P62330
    Secondary Accessions:
    • P26438
    • Q6FGZ2

    Protein attributes for ARF6 Gene

    Size:
    175 amino acids
    Molecular mass:
    20082 Da
    Quaternary structure:
    • Interacts with ARHGAP21, ASAP2, ASAP3, HERC1, PIP5K1C and UACA. The interaction with ASAP3 is stabilized by calcium ions. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Interacts with MICALL1. Interacts with KIF23, forming heterodimers and heterotetramers. Interacts with GGA1 and RAB11FIP4. Interacts with SPAG9 homodimers, forming heterotetramers. Interacts with CYTH3. Interacts with EspG from enteropathogenic E.coli. Identified in a complex with RAB1A and EspG from enteropathogenic E.coli. Interacts with the V.cholerae enterotoxin subunit A1; this causes a conformation change so that the toxin can bind NAD and catalyze the ADP-ribosylation of Gs alpha.

    Three dimensional structures from OCA and Proteopedia for ARF6 Gene

neXtProt entry for ARF6 Gene

Proteomics data for ARF6 Gene at MOPED

Post-translational modifications for ARF6 Gene

  • Ubiquitination at Lys58 and Lys69
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARF6 (ARF6)

No data available for DME Specific Peptides for ARF6 Gene

Domains for ARF6 Gene

Gene Families for ARF6 Gene

HGNC:
  • ARF :ADP-ribosylation factors

Protein Domains for ARF6 Gene

Suggested Antigen Peptide Sequences for ARF6 Gene

Graphical View of Domain Structure for InterPro Entry

P62330

UniProtKB/Swiss-Prot:

ARF6_HUMAN :
  • P62330
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF6: view

Function for ARF6 Gene

Molecular function for ARF6 Gene

GENATLAS Biochemistry: ADP ribosylation factor 6,class III,low molecular weight,widely expressed,involved in vesicular trafficking,activator of PIP5K1A
UniProtKB/Swiss-Prot EnzymeRegulation: Activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). Activated by ASAP3. Inactivated by ACAP1 and ACAP2.
UniProtKB/Swiss-Prot Function: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Gene Ontology (GO) - Molecular Function for ARF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 1993656
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 16148947
GO:0005525 GTP binding TAS 10913182
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with ARF6: view
genes like me logo Genes that share phenotypes with ARF6: view

Animal Models for ARF6 Gene

MGI Knock Outs for ARF6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARF6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARF6 Gene

Localization for ARF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF6 Gene

Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cell projection, filopodium membrane; Lipid-anchor. Midbody. Cytoplasm. Cleavage furrow. Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARF6 Gene COMPARTMENTS Subcellular localization image for ARF6 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 5
cytosol 3
cytoskeleton 2
vacuole 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 9312003
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome TAS 10913182
genes like me logo Genes that share ontologies with ARF6: view

Pathways for ARF6 Gene

genes like me logo Genes that share pathways with ARF6: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ARF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006928 movement of cell or subcellular component TAS 10036235
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ARF6: view

Compounds for ARF6 Gene

(1) HMDB Compounds for ARF6 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Drugbank Compounds for ARF6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5'-Guanosine-Diphosphate-Monothiophosphate
target
Guanosine-5'-Diphosphate
146-91-8 target
MYRISTIC ACID
target

(28) Novoseek inferred chemical compound relationships for ARF6 Gene

Compound -log(P) Hits PubMed IDs
grp-1 86.7 9
gtp 77.1 50
ac-ap 71.5 1
gdp 68.6 17
phosphatidylinositol-3,4,5-trisphosphate 58.5 2
genes like me logo Genes that share compounds with ARF6: view

Transcripts for ARF6 Gene

mRNA/cDNA for ARF6 Gene

(422) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARF6 Gene

ADP-ribosylation factor 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARF6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF6 Gene

No ASD Table

Relevant External Links for ARF6 Gene

GeneLoc Exon Structure for
ARF6
ECgene alternative splicing isoforms for
ARF6

Expression for ARF6 Gene

mRNA expression in normal human tissues for ARF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARF6 Gene

This gene is overexpressed in Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF6 Gene

SOURCE GeneReport for Unigene cluster for ARF6 Gene Hs.525330

mRNA Expression by UniProt/SwissProt for ARF6 Gene

P62330-ARF6_HUMAN
Tissue specificity: Ubiquitous, with higher levels in heart, substantia nigra, and kidney.
genes like me logo Genes that share expressions with ARF6: view

In Situ Assay Products

Orthologs for ARF6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARF6 35
  • 100 (n)
  • 100 (a)
ARF6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARF6 35
  • 97.52 (n)
  • 100 (a)
ARF6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARF6 35
  • 97.52 (n)
  • 100 (a)
ARF6 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf6 35
  • 96 (n)
  • 100 (a)
Arf6 16
Arf6 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARF6 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARF6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arf6 35
  • 96.57 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ARF6 35
  • 88.76 (n)
  • 99.43 (a)
ARF6 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARF6 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.963 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arf6.2 35
  • 84 (n)
  • 99.43 (a)
Str.15292 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1228 35
zebrafish
(Danio rerio)
Actinopterygii arf6a 36
  • 99 (a)
OneToOne
arf6b 35
  • 81.33 (n)
  • 98.86 (a)
wufj46d09 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006890 35
  • 79.31 (n)
  • 97.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf51F 35
  • 76.63 (n)
  • 97.13 (a)
Arf51F 36
  • 97 (a)
OneToOne
Arf51F 37
  • 96 (a)
worm
(Caenorhabditis elegans)
Secernentea arf-6 35
  • 73.95 (n)
  • 88.51 (a)
arf-6 36
  • 88 (a)
OneToOne
arl-6 37
  • 52 (a)
arf-6 37
  • 88 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL078W 35
  • 63.2 (n)
  • 57.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 65 (a)
ManyToMany
ARF2 36
  • 65 (a)
ManyToMany
ARF3 35
  • 56.98 (n)
  • 60.47 (a)
ARF3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13563g 35
  • 55.81 (n)
  • 56.4 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07173 35
  • 69.9 (n)
  • 70.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arf6 35
  • 62.45 (n)
  • 74.14 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11765 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9548 36
  • 81 (a)
OneToOne
Species with no ortholog for ARF6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF6 Gene

ENSEMBL:
Gene Tree for ARF6 (if available)
TreeFam:
Gene Tree for ARF6 (if available)

Paralogs for ARF6 Gene

Pseudogenes.org Pseudogenes for ARF6 Gene

genes like me logo Genes that share paralogs with ARF6: view

Variants for ARF6 Gene

Sequence variations from dbSNP and Humsavar for ARF6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15381 -- 49,894,699(+) GATGG(A/C)TTATT utr-variant-3-prime
rs15382 -- 49,894,620(+) TTTTT(A/T)TTTCG utr-variant-3-prime
rs1064615 -- 49,895,956(+) TTGTT(G/T)ATGAG utr-variant-3-prime
rs3100898 -- 49,894,043(-) GTGCA(G/T)CTCCT missense, reference
rs3100908 -- 49,892,771(-) GGGGG(A/G)CCCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARF6 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545

Relevant External Links for ARF6 Gene

HapMap Linkage Disequilibrium report
ARF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF6 Gene

Disorders for ARF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARF6 Gene including...

Search for ARF6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARF6 Gene

(6) Novoseek inferred disease relationships for ARF6 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 28 3
cholera 19.5 3
invasive cancer 7.62 3
tumors 5.14 12
breast cancer 0 12
genes like me logo Genes that share disorders with ARF6: view

No data available for UniProtKB/Swiss-Prot for ARF6 Gene

Publications for ARF6 Gene

  1. Myristoylation is required for the intracellular localization and endocytic function of ARF6. (PMID: 7589240) D'Souza-Schorey C. … Stahl P.D. (Exp. Cell Res. 1995) 3 4 23
  2. The structural GDP/GTP cycle of human Arf6. (PMID: 11266366) Pasqualato S. … Cherfils J. (EMBO Rep. 2001) 3 4 23
  3. Sequence, genomic organization, and expression of the human ADP- ribosylation factor 6 (ARF6) gene: a class III ARF. (PMID: 14659046) Lebeda R.A. … Haun R.S. (DNA Cell Biol. 2003) 3 4 23
  4. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PMID: 16148947) Fielding A.B. … Gould G.W. (EMBO J. 2005) 3 4 23
  5. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. (PMID: 15509780) Martinu L. … Chou M.M. (Mol. Cell. Biol. 2004) 3 4 23

Products for ARF6 Gene

  • Addgene plasmids for ARF6

Sources for ARF6 Gene

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