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Aliases for KIFC3 Gene

Aliases for KIFC3 Gene

  • Kinesin Family Member C3 2 3

External Ids for KIFC3 Gene

Previous GeneCards Identifiers for KIFC3 Gene

  • GC16M048187
  • GC16M057877
  • GC16M057526
  • GC16M057567
  • GC16M056349
  • GC16M057792
  • GC16M043659

Summaries for KIFC3 Gene

Entrez Gene Summary for KIFC3 Gene

  • KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different kinesin family members participate in specific and diverse motile processes, such as cell division, organelle transport, and nuclear movement (Hoang et al., 1998 [PubMed 9782090]).[supplied by OMIM, Mar 2009]

GeneCards Summary for KIFC3 Gene

KIFC3 (Kinesin Family Member C3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIFC1.

UniProtKB/Swiss-Prot for KIFC3 Gene

  • Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

Gene Wiki entry for KIFC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIFC3 Gene

Genomics for KIFC3 Gene

Regulatory Elements for KIFC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIFC3 Gene

Start:
57,758,217 bp from pter
End:
57,863,053 bp from pter
Size:
104,837 bases
Orientation:
Minus strand

Genomic View for KIFC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIFC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIFC3 Gene

Proteins for KIFC3 Gene

  • Protein details for KIFC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVG8-KIFC3_HUMAN
    Recommended name:
    Kinesin-like protein KIFC3
    Protein Accession:
    Q9BVG8
    Secondary Accessions:
    • A8K6S2
    • B7Z484
    • O75299
    • Q49A29
    • Q49AQ0
    • Q59G19
    • Q8IUT3
    • Q96HW6

    Protein attributes for KIFC3 Gene

    Size:
    833 amino acids
    Molecular mass:
    92775 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34234.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH41132.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH47051.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAD92527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIFC3 Gene

    Alternative splice isoforms for KIFC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIFC3 Gene

Proteomics data for KIFC3 Gene at MOPED

Post-translational modifications for KIFC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIFC3 Gene

Domains for KIFC3 Gene

Gene Families for KIFC3 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIFC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVG8

UniProtKB/Swiss-Prot:

KIFC3_HUMAN :
  • Q9BVG8
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIFC3: view

Function for KIFC3 Gene

Molecular function for KIFC3 Gene

GENATLAS Biochemistry: kinesin,heavy chain member C3,microtubule associated protein,ATP dependent superfamily,highly expressed in the retina and retinal pigment epithelium,homolog to morone saxatilus FKIF2
UniProtKB/Swiss-Prot Function: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

Gene Ontology (GO) - Molecular Function for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 20360068
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIFC3: view

Phenotypes for KIFC3 Gene

genes like me logo Genes that share phenotypes with KIFC3: view

Animal Model Products

CRISPR Products

miRNA for KIFC3 Gene

miRTarBase miRNAs that target KIFC3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIFC3 Gene

Localization for KIFC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIFC3 Gene

Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIFC3 Gene COMPARTMENTS Subcellular localization image for KIFC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA 19041755
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0005915 zonula adherens IDA 19041755
genes like me logo Genes that share ontologies with KIFC3: view

Pathways for KIFC3 Gene

genes like me logo Genes that share pathways with KIFC3: view

Gene Ontology (GO) - Biological Process for KIFC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007017 microtubule-based process --
GO:0007018 microtubule-based movement IBA --
GO:0007030 Golgi organization IEA --
GO:0007601 visual perception TAS 9782090
genes like me logo Genes that share ontologies with KIFC3: view

Transcripts for KIFC3 Gene

Unigene Clusters for KIFC3 Gene

Kinesin family member C3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIFC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIFC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: -
SP11:
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:

ExUns: 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17: -
SP18:
SP19:

Relevant External Links for KIFC3 Gene

GeneLoc Exon Structure for
KIFC3
ECgene alternative splicing isoforms for
KIFC3

Expression for KIFC3 Gene

mRNA expression in normal human tissues for KIFC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIFC3 Gene

SOURCE GeneReport for Unigene cluster for KIFC3 Gene Hs.23131

genes like me logo Genes that share expressions with KIFC3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIFC3 Gene

Orthologs for KIFC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIFC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIFC3 35
  • 97.42 (n)
  • 97.42 (a)
KIFC3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIFC3 35
  • 91.31 (n)
  • 96.98 (a)
KIFC3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIFC3 35
  • 91.36 (n)
  • 96.84 (a)
KIFC3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kifc3 35
  • 87.5 (n)
  • 92.84 (a)
Kifc3 16
Kifc3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIFC3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIFC3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kifc3 35
  • 88.78 (n)
  • 95.15 (a)
chicken
(Gallus gallus)
Aves KIFC3 35
  • 81.22 (n)
  • 81.47 (a)
KIFC3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIFC3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kifc3 35
  • 60.22 (n)
  • 58.13 (a)
zebrafish
(Danio rerio)
Actinopterygii kifc3 35
  • 66.34 (n)
  • 62.91 (a)
kifc3 36
  • 49 (a)
OneToOne
wufc51b05 35
fruit fly
(Drosophila melanogaster)
Insecta ncd 36
  • 26 (a)
OneToMany
ncd 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-16 36
  • 26 (a)
ManyToMany
klp-3 37
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 36
  • 25 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.2916 35
rice
(Oryza sativa)
Liliopsida Os.24220 35
wheat
(Triticum aestivum)
Liliopsida Ta.8288 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10026 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for KIFC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KIFC3 Gene

ENSEMBL:
Gene Tree for KIFC3 (if available)
TreeFam:
Gene Tree for KIFC3 (if available)

Paralogs for KIFC3 Gene

Paralogs for KIFC3 Gene

genes like me logo Genes that share paralogs with KIFC3: view

Variants for KIFC3 Gene

Sequence variations from dbSNP and Humsavar for KIFC3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs165997 -- 57,841,592(-) cctcc(C/T)ggctt intron-variant
rs173511 -- 57,842,066(+) tgatg(C/T)gcacc intron-variant
rs173512 -- 57,850,034(+) ggctg(C/T)agtga intron-variant
rs173513 -- 57,856,231(-) agtgc(A/T)gggat intron-variant
rs183638 -- 57,844,398(-) AGCTG(A/G)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIFC3 Gene

Variant ID Type Subtype PubMed ID
nsv906729 CNV Loss 21882294
nsv525464 CNV Gain 19592680
nsv528250 CNV Loss 19592680
nsv509622 CNV Insertion 20534489
dgv2872n71 CNV Loss 21882294
nsv471089 CNV Loss 18288195
dgv2873n71 CNV Loss 21882294
dgv2874n71 CNV Loss 21882294
nsv817732 CNV Loss 17921354
nsv523237 CNV Loss 19592680
nsv526855 CNV Loss 19592680

Relevant External Links for KIFC3 Gene

HapMap Linkage Disequilibrium report
KIFC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIFC3 Gene

Disorders for KIFC3 Gene

(1) University of Copenhagen DISEASES for KIFC3 Gene

Relevant External Links for KIFC3

Genetic Association Database (GAD)
KIFC3
Human Genome Epidemiology (HuGE) Navigator
KIFC3
genes like me logo Genes that share disorders with KIFC3: view

No data available for UniProtKB/Swiss-Prot for KIFC3 Gene

Publications for KIFC3 Gene

  1. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. (PMID: 9782090) Hoang E.H. … Burnside B. (Genomics 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PMID: 19041755) Meng W. … Takeichi M. (Cell 2008) 3 4

Products for KIFC3 Gene

  • Addgene plasmids for KIFC3

Sources for KIFC3 Gene

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