External Ids for KIFC3 Gene
Previous GeneCards Identifiers for KIFC3 Gene
KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different kinesin family members participate in specific and diverse motile processes, such as cell division, organelle transport, and nuclear movement (Hoang et al., 1998 [PubMed 9782090]).[supplied by OMIM, Mar 2009]
GeneCards Summary for KIFC3 Gene
KIFC3 (Kinesin Family Member C3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIFC1.
UniProtKB/Swiss-Prot for KIFC3 Gene
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.