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Aliases for ARL4D Gene

Aliases for ARL4D Gene

  • ADP Ribosylation Factor Like GTPase 4D 2 3 5
  • ADP-Ribosylation Factor-Like Protein 4L 3 4
  • ADP-Ribosylation Factor-Like 4D 2 3
  • ARF4L 3 4
  • ADP-Ribosylation Factor Like GTPase 4D 3
  • ADP-Ribosylation Factor 4-Like 2
  • ADP-Ribosylation Factor-Like 6 3
  • ARL6 3

External Ids for ARL4D Gene

Previous HGNC Symbols for ARL4D Gene

  • ARF4L

Previous GeneCards Identifiers for ARL4D Gene

  • GC17P038832
  • GC17P041476
  • GC17P037238

Summaries for ARL4D Gene

Entrez Gene Summary for ARL4D Gene

  • ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4D Gene

ARL4D (ADP Ribosylation Factor Like GTPase 4D) is a Protein Coding gene. Diseases associated with ARL4D include Bardet-Biedl Syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL11.

UniProtKB/Swiss-Prot for ARL4D Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Wiki entry for ARL4D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4D Gene

Genomics for ARL4D Gene

Regulatory Elements for ARL4D Gene

Enhancers for ARL4D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL4D on UCSC Golden Path with GeneCards custom track

Promoters for ARL4D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL4D on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL4D Gene

Chromosome:
17
Start:
43,398,959 bp from pter
End:
43,401,137 bp from pter
Size:
2,179 bases
Orientation:
Plus strand

Genomic View for ARL4D Gene

Genes around ARL4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4D Gene

Proteins for ARL4D Gene

  • Protein details for ARL4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49703-ARL4D_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4D
    Protein Accession:
    P49703
    Secondary Accessions:
    • B2RC59
    • D3DX43

    Protein attributes for ARL4D Gene

    Size:
    201 amino acids
    Molecular mass:
    22156 Da
    Quaternary structure:
    • Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.

neXtProt entry for ARL4D Gene

Proteomics data for ARL4D Gene at MOPED

Post-translational modifications for ARL4D Gene

  • Ubiquitination at Lys 44
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL4D Gene

Domains & Families for ARL4D Gene

Gene Families for ARL4D Gene

Suggested Antigen Peptide Sequences for ARL4D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49703

UniProtKB/Swiss-Prot:

ARL4D_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4D: view

Function for ARL4D Gene

Molecular function for ARL4D Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Ontology (GO) - Molecular Function for ARL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17398095
genes like me logo Genes that share ontologies with ARL4D: view
genes like me logo Genes that share phenotypes with ARL4D: view

Animal Models for ARL4D Gene

MGI Knock Outs for ARL4D:

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL4D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL4D Gene

Localization for ARL4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4D Gene

Nucleus, nucleolus. Cell membrane. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL4D Gene COMPARTMENTS Subcellular localization image for ARL4D gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ARL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 17398095
genes like me logo Genes that share ontologies with ARL4D: view

Pathways & Interactions for ARL4D Gene

SuperPathways for ARL4D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL4D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARL4D Gene

Drugs & Compounds for ARL4D Gene

No Compound Related Data Available

Transcripts for ARL4D Gene

mRNA/cDNA for ARL4D Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(255) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL4D Gene

ADP-ribosylation factor-like 4D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4D Gene

No ASD Table

Relevant External Links for ARL4D Gene

GeneLoc Exon Structure for
ARL4D
ECgene alternative splicing isoforms for
ARL4D

Expression for ARL4D Gene

mRNA expression in normal human tissues for ARL4D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL4D Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

SOURCE GeneReport for Unigene cluster for ARL4D Gene Hs.183153

genes like me logo Genes that share expression patterns with ARL4D: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARL4D Gene

Orthologs for ARL4D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL4D 35
  • 89.83 (n)
  • 97.5 (a)
ARL4D 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL4D 35
  • 91.21 (n)
  • 99 (a)
ARL4D 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl4d 35
  • 86.24 (n)
  • 95.02 (a)
Arl4d 16
Arl4d 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARL4D 35
  • 99.67 (n)
  • 100 (a)
ARL4D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl4d 35
  • 86.24 (n)
  • 95.02 (a)
oppossum
(Monodelphis domestica)
Mammalia ARL4D 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL4D 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arl4d 35
  • 69.33 (n)
  • 76 (a)
wufc03d05 35
arl4d 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1686 35
fruit fly
(Drosophila melanogaster)
Insecta CG2219 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 36
  • 38 (a)
OneToMany
Species with no ortholog for ARL4D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4D Gene

ENSEMBL:
Gene Tree for ARL4D (if available)
TreeFam:
Gene Tree for ARL4D (if available)

Paralogs for ARL4D Gene

Paralogs for ARL4D Gene

(28) SIMAP similar genes for ARL4D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL4D: view

Variants for ARL4D Gene

Sequence variations from dbSNP and Humsavar for ARL4D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1059968 - 43,400,004(+) TTATA(A/C)CCGCC reference, missense
rs10651 -- 43,400,649(+) TTTAA(C/T)TGGAT utr-variant-3-prime
rs11493 -- 43,400,815(+) CCAAG(A/G)ACCCC utr-variant-3-prime
rs749475 -- 43,398,890(+) GGGGC(C/T)GCAGC upstream-variant-2KB
rs753396 -- 43,399,475(-) GGGGG(A/G)CGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL4D Gene

Variant ID Type Subtype PubMed ID
dgv3173n71 CNV Gain 21882294
nsv833451 CNV Loss 17160897
nsv833452 CNV Loss 17160897
nsv470588 CNV Gain 18288195

Variation tolerance for ARL4D Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARL4D Gene

Disorders for ARL4D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL4D Gene - From: GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ARL4D in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARL4D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL4D
genes like me logo Genes that share disorders with ARL4D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL4D Gene

Publications for ARL4D Gene

  1. Isolation and mapping of a gene encoding a novel human ADP- ribosylation factor on chromosome 17q12-q21. (PMID: 7590735) Smith S.A. … Albertsen H. (Genomics 1995) 2 3 4 67
  2. GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential. (PMID: 22927989) Li C.C. … Lee F.J. (PLoS ONE 2012) 2 3
  3. Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors. (PMID: 12472661) Nonaka Y. … Itoh K. (Tissue Antigens 2002) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3

Products for ARL4D Gene

Sources for ARL4D Gene

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