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Aliases for KCNN3 Gene

Aliases for KCNN3 Gene

  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 3 2 3
  • SKCA3 3 4 6
  • SK3 3 4 6
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 2 3
  • Small Conductance Calcium-Activated Potassium Channel 3 2 3
  • SKCa 3 3 4
  • KCa2.3 3 4
  • Small Conductance Calcium-Activated Potassium Channel Protein 3 3
  • HSK3 3
  • K3 4

External Ids for KCNN3 Gene

Previous GeneCards Identifiers for KCNN3 Gene

  • GC01M152495
  • GC01M150410
  • GC01M151455
  • GC01M151896
  • GC01M151492
  • GC01M152946
  • GC01M154680
  • GC01M126042

Summaries for KCNN3 Gene

Entrez Gene Summary for KCNN3 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for KCNN3 Gene

KCNN3 (Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include spinocerebellar ataxia 2 and bipolar disorder. Among its related pathways are Transmission across Chemical Synapses and Insulin secretion. GO annotations related to this gene include calmodulin binding and small conductance calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.

UniProtKB/Swiss-Prot for KCNN3 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin

Tocris Summary for KCNN3 Gene

  • Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable and non-excitable cells. The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.

Gene Wiki entry for KCNN3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN3 Gene

Genomics for KCNN3 Gene

Regulatory Elements for KCNN3 Gene

Transcription factor binding sites by QIAGEN in the KCNN3 gene promoter:

Genomic Location for KCNN3 Gene

154,697,455 bp from pter
154,870,280 bp from pter
172,826 bases
Minus strand

Genomic View for KCNN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN3 Gene

Proteins for KCNN3 Gene

  • Protein details for KCNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small conductance calcium-activated potassium channel protein 3
    Protein Accession:
    Secondary Accessions:
    • B1ANX0
    • O43517
    • Q86VF9
    • Q8WXG7

    Protein attributes for KCNN3 Gene

    736 amino acids
    Molecular mass:
    82026 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Alternative splice isoforms for KCNN3 Gene


neXtProt entry for KCNN3 Gene

Proteomics data for KCNN3 Gene at MOPED

Post-translational modifications for KCNN3 Gene

  • Ubiquitination at Lys555
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNN3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNN3 Gene

Domains for KCNN3 Gene

Gene Families for KCNN3 Gene

  • KCN :Potassium channels
  • KCa :Voltage-gated ion channels / Potassium channels, calcium-activated

Graphical View of Domain Structure for InterPro Entry



  • Q9UGI6
  • Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
genes like me logo Genes that share domains with KCNN3: view

Function for KCNN3 Gene

Molecular function for KCNN3 Gene

GENATLAS Biochemistry: potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3
UniProtKB/Swiss-Prot Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin

Gene Ontology (GO) - Molecular Function for KCNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity --
GO:0016286 small conductance calcium-activated potassium channel activity IBA --
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with KCNN3: view
genes like me logo Genes that share phenotypes with KCNN3: view

Animal Models for KCNN3 Gene

MGI Knock Outs for KCNN3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNN3 Gene

Localization for KCNN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KCNN3 Gene COMPARTMENTS Subcellular localization image for KCNN3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030175 filopodium --
GO:0031594 neuromuscular junction --
genes like me logo Genes that share ontologies with KCNN3: view

Pathways for KCNN3 Gene

genes like me logo Genes that share pathways with KCNN3: view

Pathways by source for KCNN3 Gene

1 KEGG pathway for KCNN3 Gene

Interacting Proteins for KCNN3 Gene

Gene Ontology (GO) - Biological Process for KCNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0007268 synaptic transmission TAS --
GO:0071805 potassium ion transmembrane transport IBA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with KCNN3: view

Compounds for KCNN3 Gene

(5) Tocris Compounds for KCNN3 Gene

Compound Action Cas Number
Apamin KCa2 channel blocker (small conductance) [24345-16-2]
Iberiotoxin KCa channel blocker (big conductance) [129203-60-7]
Paxilline SERCA ATPase blocker. Also potent BKCa channel blocker [57186-25-1]
TRAM 34 Potent and highly selective KCa3.1 channel blocker [289905-88-0]
UCL 1684 Highly potent blocker of KCa2 [199934-16-2]

(1) HMDB Compounds for KCNN3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for KCNN3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
22916-47-8 target inhibitor

(13) IUPHAR Ligand for KCNN3 Gene

Ligand Type Action Affinity Pubmed IDs
UCL1684 Pore Blocker None 9.1
apamin Pore Blocker Antagonist 8.1
P05 Pore Blocker Agonist 7.6
leiurotoxin I Pore Blocker Antagonist 7.1
NS8593 Gating inhibitor Antagonist 6.4
dequalinium chloride Pore Blocker Antagonist 6.4
CyPPA Activator Agonist 5.3
Lei-Dab7 Pore Blocker Antagonist 5.2
(+)-tubocurarine Antagonist Antagonist 5.2
DC-EBIO Activator Agonist 4.9
Ca2+ Antagonist Antagonist
EBIO Activator Agonist
NS309 Activator Agonist

(9) Novoseek inferred chemical compound relationships for KCNN3 Gene

Compound -log(P) Hits PubMed IDs
scyllatoxin 86.9 1
1-ethyl-2-benzimidazolinone 83.7 1
apamin 80.2 5
potassium 66.5 18
d-tubocurarine 49.5 1
genes like me logo Genes that share compounds with KCNN3: view

Transcripts for KCNN3 Gene

Unigene Clusters for KCNN3 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP2: - -
SP3: -
SP4: - -

Relevant External Links for KCNN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNN3 Gene

mRNA expression in normal human tissues for KCNN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNN3 Gene

SOURCE GeneReport for Unigene cluster for KCNN3 Gene Hs.490765

genes like me logo Genes that share expressions with KCNN3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KCNN3 Gene

Orthologs for KCNN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNN3 35
  • 98.9 (n)
  • 98.7 (a)
KCNN3 36
  • 100 (a)
(Bos Taurus)
Mammalia KCNN3 35
  • 93.53 (n)
  • 95.84 (a)
KCNN3 36
  • 98 (a)
(Canis familiaris)
Mammalia KCNN3 35
  • 90.4 (n)
  • 94.63 (a)
KCNN3 36
  • 95 (a)
(Mus musculus)
Mammalia Kcnn3 35
  • 89.88 (n)
  • 93.43 (a)
Kcnn3 16
Kcnn3 36
  • 96 (a)
(Monodelphis domestica)
Mammalia KCNN3 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia KCNN3 36
  • 61 (a)
(Rattus norvegicus)
Mammalia Kcnn3 35
  • 90.06 (n)
  • 93.84 (a)
(Gallus gallus)
Aves KCNN3 36
  • 94 (a)
(Anolis carolinensis)
Reptilia KCNN3 36
  • 93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.113 35
(Danio rerio)
Actinopterygii kcnn3 35
  • 70.7 (n)
  • 76.59 (a)
kcnn3 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta SK 36
  • 36 (a)
SK 37
  • 54 (a)
(Caenorhabditis elegans)
Secernentea kcnl-1 36
  • 26 (a)
kcnl-2 36
  • 31 (a)
kcnl-3 36
  • 26 (a)
kcnl-4 36
  • 27 (a)
C03F11.1 37
  • 37 (a)
C53A5.5 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for KCNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN3 Gene

Gene Tree for KCNN3 (if available)
Gene Tree for KCNN3 (if available)

Paralogs for KCNN3 Gene

Paralogs for KCNN3 Gene

Selected SIMAP similar genes for KCNN3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KCNN3: view

Variants for KCNN3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN3 Gene

The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population

Sequence variations from dbSNP and Humsavar for KCNN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs868108 -- 154,747,813(+) ACTGC(C/G)GCATC intron-variant
rs870031 -- 154,751,527(+) CTTCT(A/G)ATGGC intron-variant
rs870327 -- 154,822,801(-) AGGGT(A/C)CTTCT intron-variant
rs870328 -- 154,822,816(+) GTCCC(G/T)CCTGC intron-variant
rs883319 -- 154,785,946(+) AATAG(C/T)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN3 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
nsv470740 CNV Gain 18288195
nsv464050 CNV Gain 19166990
nsv509491 CNV Insertion 20534489
esv2574257 CNV Insertion 19546169
esv1554680 CNV Insertion 17803354
esv2718350 CNV Deletion 23290073
esv2673228 CNV Deletion 23128226
nsv872452 CNV Gain 21882294
esv275470 CNV Gain+Loss 21479260
esv2718363 CNV Deletion 23290073
esv29982 CNV Gain 17803354
nsv2966 CNV Insertion 18451855
nsv464073 CNV Loss 19166990

Relevant External Links for KCNN3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for KCNN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for KCNN3 Gene including...

Search for KCNN3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KCNN3 Gene

(5) Novoseek inferred disease relationships for KCNN3 Gene

Disease -log(P) Hits PubMed IDs
hirschsprung disease 58.5 2
schizophrenia 54.8 31
myotonic dystrophy 50.6 3
bipolar disorder 48.2 9
anorexia nervosa 28.8 1

Relevant External Links for KCNN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KCNN3: view

No data available for UniProtKB/Swiss-Prot for KCNN3 Gene

Publications for KCNN3 Gene

  1. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. (PMID: 11121173) Saleem Q. … Jain S. (Am. J. Med. Genet. 2000) 3 23 48
  2. Genomic organization and promoter analysis of human KCNN3 gene. (PMID: 11501944) Sun G. … Gargus J.J. (J. Hum. Genet. 2001) 3 4 23
  3. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. (PMID: 11526470) Meira-Lima I.V. … Vallada H. (Mol. Psychiatry 2001) 3 23 48
  4. Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder. (PMID: 11311923) Ujike H. … Kuroda S. (Psychiatry Res 2001) 3 23 48
  5. CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. (PMID: 12497613) Laurent C. … Mallet J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48

Products for KCNN3 Gene

Sources for KCNN3 Gene

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