Aliases for KCNN3 Gene
- Potassium Calcium-Activated Channel Subfamily N Member 3 2 3
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 3 2 3 5
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 3 2 3
- Small Conductance Calcium-Activated Potassium Channel 3 2 3
- SKCa 3 3 4
- KCa2.3 3 4
External Ids for KCNN3 Gene
Previous GeneCards Identifiers for KCNN3 Gene
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for KCNN3 Gene
KCNN3 (Potassium Calcium-Activated Channel Subfamily N Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include spinocerebellar ataxia 2 and hirschsprung disease 1. Among its related pathways are Transmission across Chemical Synapses and Insulin secretion. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN1.
UniProtKB/Swiss-Prot for KCNN3 Gene
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).