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Aliases for ARF4 Gene

Aliases for ARF4 Gene

  • ADP Ribosylation Factor 4 2 3 5
  • ADP-Ribosylation Factor 2 2 3
  • ARF2 3 4

External Ids for ARF4 Gene

Previous HGNC Symbols for ARF4 Gene

  • ARF2

Previous GeneCards Identifiers for ARF4 Gene

  • GC03M056428
  • GC03M056911
  • GC03M057411
  • GC03M057514
  • GC03M057507
  • GC03M057532

Summaries for ARF4 Gene

Entrez Gene Summary for ARF4 Gene

  • This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF4 Gene

ARF4 (ADP Ribosylation Factor 4) is a Protein Coding gene. Diseases associated with ARF4 include Cholera. Among its related pathways are Golgi-to-ER retrograde transport and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF4 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Gene Wiki entry for ARF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF4 Gene

Genomics for ARF4 Gene

Regulatory Elements for ARF4 Gene

Enhancers for ARF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARF4 on UCSC Golden Path with GeneCards custom track

Promoters for ARF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARF4 Gene

Chromosome:
3
Start:
57,571,363 bp from pter
End:
57,598,220 bp from pter
Size:
26,858 bases
Orientation:
Minus strand

Genomic View for ARF4 Gene

Genes around ARF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF4 Gene

Proteins for ARF4 Gene

  • Protein details for ARF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18085-ARF4_HUMAN
    Recommended name:
    ADP-ribosylation factor 4
    Protein Accession:
    P18085
    Secondary Accessions:
    • B2R7J7
    • P21371

    Protein attributes for ARF4 Gene

    Size:
    180 amino acids
    Molecular mass:
    20511 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARF4 Gene

neXtProt entry for ARF4 Gene

Proteomics data for ARF4 Gene at MOPED

Post-translational modifications for ARF4 Gene

  • Ubiquitination at Lys 142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF4 Gene

No data available for DME Specific Peptides for ARF4 Gene

Domains & Families for ARF4 Gene

Gene Families for ARF4 Gene

Protein Domains for ARF4 Gene

Suggested Antigen Peptide Sequences for ARF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18085

UniProtKB/Swiss-Prot:

ARF4_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF4: view

Function for ARF4 Gene

Molecular function for ARF4 Gene

GENATLAS Biochemistry:
ADP ribosylation factor 4,class II,20kDa,low molecular weight GTP binding protein,a guanine nucleotide dependent protein activator of cholera toxin,widely expressed,except in brain,involved in vesicular trafficking and activation of phospholipase D
UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with ARF4: view
genes like me logo Genes that share phenotypes with ARF4: view

Animal Models for ARF4 Gene

MGI Knock Outs for ARF4:
  • Arf4 tm1b(KOMP)Wtsi

Animal Model Products

miRNA for ARF4 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF4 Gene

Localization for ARF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF4 Gene

Golgi apparatus. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARF4 Gene COMPARTMENTS Subcellular localization image for ARF4 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
golgi apparatus 4
endoplasmic reticulum 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0032587 ruffle membrane IDA 12446727
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with ARF4: view

Pathways & Interactions for ARF4 Gene

genes like me logo Genes that share pathways with ARF4: view

Gene Ontology (GO) - Biological Process for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IDA 1899243
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0007612 learning IEA --
GO:0043547 positive regulation of GTPase activity TAS --
GO:0045176 apical protein localization IEA --
genes like me logo Genes that share ontologies with ARF4: view

No data available for SIGNOR curated interactions for ARF4 Gene

Drugs & Compounds for ARF4 Gene

(3) Drugs for ARF4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARF4: view

Transcripts for ARF4 Gene

Unigene Clusters for ARF4 Gene

ADP-ribosylation factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARF4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for ARF4 Gene

GeneLoc Exon Structure for
ARF4
ECgene alternative splicing isoforms for
ARF4

Expression for ARF4 Gene

mRNA expression in normal human tissues for ARF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF4 Gene



SOURCE GeneReport for Unigene cluster for ARF4 Gene Hs.652183

genes like me logo Genes that share expression patterns with ARF4: view

Protein tissue co-expression partners for ARF4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF4 Gene

Orthologs for ARF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ARF4 35
  • 95.37 (n)
  • 96.67 (a)
ARF4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf4 35
  • 92.59 (n)
  • 96.11 (a)
Arf4 16
Arf4 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARF4 35
  • 99.63 (n)
  • 100 (a)
ARF4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arf4 35
  • 91.48 (n)
  • 96.11 (a)
cow
(Bos Taurus)
Mammalia ARF4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARF4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARF4 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARF4 35
  • 83.84 (n)
  • 93.33 (a)
ARF4 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARF4 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arf4 35
  • 79.26 (n)
  • 95.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398551 35
zebrafish
(Danio rerio)
Actinopterygii arf4a 35
  • 76.85 (n)
  • 90.56 (a)
ARF4 (2 of 3) 36
  • 69 (a)
OneToMany
ARF4 (3 of 3) 36
  • 70 (a)
OneToMany
arf4a 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 37
  • 84 (a)
Arf79F 37
  • 82 (a)
Arf102F 35
  • 69.26 (n)
  • 84.44 (a)
Arf102F 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002931 35
  • 71.3 (n)
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea arf-1 37
  • 81 (a)
arf-3 37
  • 84 (a)
arl-5 37
  • 46 (a)
arl-6 37
  • 58 (a)
arf-3 36
  • 84 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 72 (a)
ManyToMany
ARF2 36
  • 71 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
OneToMany
Species with no ortholog for ARF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF4 Gene

ENSEMBL:
Gene Tree for ARF4 (if available)
TreeFam:
Gene Tree for ARF4 (if available)

Paralogs for ARF4 Gene

Pseudogenes.org Pseudogenes for ARF4 Gene

genes like me logo Genes that share paralogs with ARF4: view

Variants for ARF4 Gene

Sequence variations from dbSNP and Humsavar for ARF4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_048317 -

Variation tolerance for ARF4 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARF4 Gene

Human Gene Mutation Database (HGMD)
ARF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARF4 Gene

Disorders for ARF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARF4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
- elite association - COSMIC cancer census association via MalaCards
Search ARF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARF4
genes like me logo Genes that share disorders with ARF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF4 Gene

Publications for ARF4 Gene

  1. Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. (PMID: 2107548) Monaco L. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 67
  2. Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. (PMID: 19041174) Woo I.S. … Seo H.G. (Cancer Lett. 2009) 3 23
  3. Cloning and characterization of the human ADP-ribosylation factor 4 gene. (PMID: 10524252) Lebeda R.A. … Haun R.S. (Gene 1999) 3 23
  4. Human ADP-ribosylation factor 4 (ARF4) gene. Map position 3p14.1. (PMID: 10099884) Kim H.S. (Chromosome Res. 1998) 3 23
  5. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3

Products for ARF4 Gene

Sources for ARF4 Gene

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