Aliases for KCNJ15 Gene
Aliases for KCNJ15 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 15 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 15 3 5
- Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
- Inward Rectifier K(+) Channel Kir1.3 3 4
- Inward Rectifier K(+) Channel Kir4.2 3 4
External Ids for KCNJ15 Gene
- HGNC: 6261
- Entrez Gene: 3772
- Ensembl: ENSG00000157551
- OMIM: 602106
- UniProtKB: Q99712
Previous GeneCards Identifiers for KCNJ15 Gene
- GC21P036206
- GC21P036289
- GC21P038549
- GC21P038550
- GC21P039628
- GC21P025098
- GC21P039529
Summaries for KCNJ15 Gene
-
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ15 Gene
KCNJ15 (Potassium Voltage-Gated Channel Subfamily J Member 15) is a Protein Coding gene. Diseases associated with KCNJ15 include Corneal Dystrophy, Schnyder Type. Among its related pathways are Inwardly rectifying K+ channels and Transmission across Chemical Synapses. GO annotations related to this gene include potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.
UniProtKB/Swiss-Prot for KCNJ15 Gene
-
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
-
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ15 Gene
Genomics for KCNJ15 Gene
Regulatory Elements for KCNJ15 Gene
Enhancers for KCNJ15 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around KCNJ15 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the KCNJ15 gene promoter:
Regulatory Element Products
Genomic Location for KCNJ15 Gene
- Chromosome:
- 21
- Start:
- 38,157,034 bp from pter
- End:
- 38,307,357 bp from pter
- Size:
- 150,324 bases
- Orientation:
- Plus strand
Genomic View for KCNJ15 Gene
Genes around KCNJ15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.13 by Ensembl
- 21q22.2 by Entrez Gene
- 21q22.2 by HGNC
KCNJ15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNJ15 Gene
Proteins for KCNJ15 Gene
-
Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99712-KCJ15_HUMAN
- Recommended name:
- ATP-sensitive inward rectifier potassium channel 15
- Protein Accession:
- Q99712
- D3DSH5
- O00564
- Q96L28
- Q99446
Protein attributes for KCNJ15 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 42577 Da
- Quaternary structure:
-
- Interacts with INADL.
Protein Expression for KCNJ15 Gene
Post-translational modifications for KCNJ15 Gene
Other Protein References for KCNJ15 Gene
- ENSEMBL proteins:
-
- ENSP00000381899
- ENSP00000381901
- ENSP00000381902
- ENSP00000381904
- ENSP00000381905
- ENSP00000381907
- ENSP00000381911
- ENSP00000392951
- ENSP00000400849
- ENSP00000413013
- ENSP00000414487
- ENSP00000447111
- ENSP00000448676
- ENSP00000448770
- ENSP00000448886
- ENSP00000449140
- ENSP00000449419
- ENSP00000450254
- ENSP00000479100
- ENSP00000484960
- ENSP00000331698
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KCNJ15
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- antibodies-online Antibodies for KCNJ15: See all 37
- Search GeneTex for Antibodies for KCNJ15
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNJ15
Protein Products
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- antibodies-online Proteins for KCNJ15: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for KCNJ15
- Abcam proteins for KCNJ15
Assay Products
- antibodies-online Kits for KCNJ15: See all 4
No data available for DME Specific Peptides for KCNJ15 Gene
Domains & Families for KCNJ15 Gene
Gene Families for KCNJ15 Gene
- HGNC:
- IUPHAR :
Protein Domains for KCNJ15 Gene
Suggested Antigen Peptide Sequences for KCNJ15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99712UniProtKB/Swiss-Prot:
KCJ15_HUMAN :- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
- Family:
-
- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
Function for KCNJ15 Gene
Molecular function for KCNJ15 Gene
- GENATLAS Biochemistry:
- potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
- UniProtKB/Swiss-Prot Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Phenotypes for KCNJ15 Gene
- MGI mutant phenotypes for KCNJ15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNJ15:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- Decreased homologous recombination repair frequency
Animal Models for KCNJ15 Gene
- MGI Knock Outs for KCNJ15:
-
- Kcnj15 tm1Dgen
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNJ15
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ViGene Biosciences lentiviral particle packaged cDNA for KCNJ15 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for KCNJ15
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ15
- GenScript: Design CRISPR guide RNA sequences for KCNJ15
miRNA for KCNJ15 Gene
- miRTarBase miRNAs that target KCNJ15
-
- hsa-mir-9-5p (MIRT021341)
- hsa-mir-98-5p (MIRT027409)
- hsa-mir-498 (MIRT569798)
- hsa-mir-298 (MIRT569799)
- hsa-mir-548ao-3p (MIRT569800)
- hsa-mir-4684-5p (MIRT687789)
- hsa-mir-6827-3p (MIRT687790)
- hsa-mir-340-3p (MIRT687791)
- hsa-mir-433-5p (MIRT687792)
- hsa-mir-6771-3p (MIRT687793)
- hsa-mir-548x-3p (MIRT687794)
- hsa-mir-548j-3p (MIRT687795)
- hsa-mir-548aq-3p (MIRT687796)
- hsa-mir-548am-3p (MIRT687797)
- hsa-mir-548aj-3p (MIRT687798)
- hsa-mir-548ah-3p (MIRT687799)
- hsa-mir-548ae-3p (MIRT687800)
- hsa-mir-548z (MIRT687801)
- hsa-mir-548h-3p (MIRT687802)
- hsa-mir-548d-3p (MIRT687803)
- hsa-mir-548bb-3p (MIRT687804)
- hsa-mir-548ac (MIRT687805)
miRNA Products
- Search ViGene Biosciences for KCNJ15
Clone Products
- OriGene clones in human for KCNJ15
- OriGene ORF clones in human,mouse,rat for KCNJ15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
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ViGene Biosciences adenoviral particle packaged cDNA for KCNJ15 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNJ15 Gene
Localization for KCNJ15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for KCNJ15 Gene
More details on SuperPathways for KCNJ15| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Inwardly rectifying K+ channels | ||
| 2 | GABA receptor activation | ||
| 3 | Transmission across Chemical Synapses |
.70
|
|
| 4 | Salivary secretion | ||
| 5 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Pathways by source for KCNJ15 Gene
11 Reactome pathways for KCNJ15 Gene
1 KEGG pathway for KCNJ15 Gene
1 Qiagen pathway for KCNJ15 Gene
Interacting Proteins for KCNJ15 Gene
Selected Interacting proteins:
Q99712-KCJ15_HUMAN
ENSP00000331698
for KCNJ15 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006813 | potassium ion transport | IEA,TAS | 8995301 |
No data available for SIGNOR curated interactions for KCNJ15 Gene
Drugs & Compounds for KCNJ15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Yohimbine | Approved | Pharma | Antagonist, Target | 25 | ||
| Diazoxide | Approved | Pharma | Activator | Blocks desensitization of AMPA receptors | 21 | |
| Minoxidil | Approved | Pharma | Activator | Kir6 channel (KATP) opener | 34 | |
| Magnesium | Nutra | 0 | ||||
| Cromakalim | Pharma | Activator | Kir6 (KATP) channel opener | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| P1075 |
|
60559-98-0 |
|
|
||
| ZM 226600 |
|
147695-92-9 |
|
|
(5) Tocris Compounds for KCNJ15 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cromakalim | Kir6 (KATP) channel opener | 94470-67-4 |
| Diazoxide | Blocks desensitization of AMPA receptors | 364-98-7 |
| Minoxidil | Kir6 channel (KATP) opener | 38304-91-5 |
| P1075 | Potent Kir6 (KATP) channel opener | 60559-98-0 |
| ZM 226600 | Kir6 (KATP) channel opener | 147695-92-9 |
Transcripts for KCNJ15 Gene
mRNA/cDNA for KCNJ15 Gene
- (12) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (67) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KCNJ15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KCNJ15
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ15
- GenScript: Design CRISPR guide RNA sequences for KCNJ15
miRNA Products
- Search ViGene Biosciences for KCNJ15
Clone Products
- OriGene clones in human for KCNJ15
- OriGene ORF clones in human,mouse,rat for KCNJ15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KCNJ15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for KCNJ15 Gene
mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene
This gene is overexpressed in Whole Blood (x26.9) and Kidney - Cortex (x7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ15 Gene
SOURCE GeneReport for Unigene cluster for KCNJ15 Gene Hs.411299
Primer Products
-
OriGene qPCR primer pairs and template standards for KCNJ15
-
OriGene qPCR primer pairs for KCNJ15
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KCNJ15 Gene
Orthologs for KCNJ15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | KCNJ15 35 |
|
||
| KCNJ15 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | KCNJ15 35 |
|
||
| KCNJ15 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Kcnj15 35 |
|
||
| Kcnj15 16 |
|
||||
| Kcnj15 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | KCNJ15 35 |
|
||
| KCNJ15 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Kcnj15 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KCNJ15 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | KCNJ15 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KCNJ15 35 |
|
||
| KCNJ15 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | KCNJ15 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | kcnj15 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68935 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC572476 35 |
|
||
| KCNJ15 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Irk3 37 |
|
|
|
| Ir 36 |
|
ManyToMany | |||
| Irk2 36 |
|
ManyToMany |
- Species with no ortholog for KCNJ15:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KCNJ15 Gene
Paralogs for KCNJ15 Gene
(16) SIMAP similar genes for KCNJ15 Gene using alignment to 9 proteins:
Variants for KCNJ15 Gene
| SNP ID | Clin | Chr 21 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2230033 | - | 38,299,554(+) | ACCCG(A/G)TGAGC | reference, missense | |
| rs3746875 | - | 38,299,349(+) | GCGTC(A/C)TGTCC | reference, missense | |
| rs199857043 | A breast cancer sample | 38,299,472(+) | TGTTC(A/G)CTGCC | reference, missense | |
| rs2251360 | -- | 38,277,627(+) | GAGCG(A/G)GTGCA | intron-variant | |
| rs2298331 | -- | 38,300,933(+) | ATAGT(A/C)ATTTC | utr-variant-3-prime |
Residual Variation Intolerance Score:
47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.64;
65.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for KCNJ15 Gene
- Human Gene Mutation Database (HGMD)
- KCNJ15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ15 Gene
Disorders for KCNJ15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| corneal dystrophy, schnyder type |
|
|
Search KCNJ15 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for KCNJ15
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNJ15 Gene
Publications for KCNJ15 Gene
- A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P. … Creau N. (Genomics 1997) 2 3 4 23 67
- International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y. … Vandenberg C.A. (Pharmacol. Rev. 2005) 2 3
- Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. (PMID: 11804844) Hill C.E. … Magtanong L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002) 3 23
- Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck M.E. … Bienkowski M.J. (J. Biol. Chem. 1997) 2 3
- Potassium channel KCNJ15 is required for histamine-stimulated gastric acid secretion. (PMID: 26108660) Yuan J. … Zhu L. (Am. J. Physiol., Cell Physiol. 2015) 3
Products for KCNJ15 Gene
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- antibodies-online Antibodies for KCNJ15: See all 37
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- ViGene Biosciences adenoviral particle packaged cDNA for KCNJ15 gene
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Sources for KCNJ15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
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