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Aliases for KCNJ15 Gene

Aliases for KCNJ15 Gene

  • Potassium Voltage-Gated Channel Subfamily J Member 15 2 3 5
  • Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2 3
  • Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
  • Inward Rectifier K(+) Channel Kir1.3 3 4
  • Inward Rectifier K(+) Channel Kir4.2 3 4
  • ATP-Sensitive Inward Rectifier Potassium Channel 15 3
  • Inward Rectifier K+ Channel KIR4.2 3
  • KIR1.3 3
  • KIR4.2 3
  • KCNJ14 4
  • IRKK 3

External Ids for KCNJ15 Gene

Previous GeneCards Identifiers for KCNJ15 Gene

  • GC21P036206
  • GC21P036289
  • GC21P038549
  • GC21P038550
  • GC21P039628
  • GC21P025098
  • GC21P039529

Summaries for KCNJ15 Gene

Entrez Gene Summary for KCNJ15 Gene

  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KCNJ15 Gene

KCNJ15 (Potassium Voltage-Gated Channel Subfamily J Member 15) is a Protein Coding gene. Diseases associated with KCNJ15 include Leber Congenital Amaurosis 16 and Schnyder Corneal Dystrophy. Among its related pathways are Salivary secretion and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ10.

UniProtKB/Swiss-Prot for KCNJ15 Gene

  • Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Tocris Summary for KCNJ15 Gene

  • The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.

Gene Wiki entry for KCNJ15 Gene

Additional gene information for KCNJ15 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNJ15 Gene

Genomics for KCNJ15 Gene

GeneHancer (GH) Regulatory Elements for KCNJ15 Gene

Promoters and enhancers for KCNJ15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I038256 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.3 +101.5 101494 3.2 SP1 FOSL2 FOS BMI1 KCNJ15 LOC105372801 SPATA20P1
GH21I038296 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 554.8 +140.3 140255 2.2 RXRA ZBTB2 DACH1 MAX REST EP300 NR2F2 GABPA JUND GMEB1 KCNJ15 DSCR8 GC21P038273 GC21M038327
GH21I038272 Promoter/Enhancer 0.9 EPDnew Ensembl dbSUPER 555.4 +115.4 115367 0.4 KCNJ15 GC21P038273 LOC105372801
GH21I038257 Promoter/Enhancer 0.8 EPDnew Ensembl 550.2 +99.7 99667 0.2 PRDM1 KCNJ15 LOC105372801 SPATA20P1
GH21I038227 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 32.1 +71.4 71367 1.5 SMARCE1 DPF2 BATF E2F1 SP1 ZNF217 GATA3 CTBP1 NBN TRIM28 KCNJ15 GC21M038236 DSCR10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNJ15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNJ15 gene promoter:

Genomic Locations for KCNJ15 Gene

Genomic Locations for KCNJ15 Gene
chr21:38,157,034-38,307,357
(GRCh38/hg38)
Size:
150,324 bases
Orientation:
Plus strand
chr21:39,529,128-39,679,279
(GRCh37/hg19)

Genomic View for KCNJ15 Gene

Genes around KCNJ15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNJ15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNJ15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNJ15 Gene

Proteins for KCNJ15 Gene

  • Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99712-KCJ15_HUMAN
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Protein Accession:
    Q99712
    Secondary Accessions:
    • D3DSH5
    • O00564
    • Q96L28
    • Q99446

    Protein attributes for KCNJ15 Gene

    Size:
    375 amino acids
    Molecular mass:
    42577 Da
    Quaternary structure:
    • Interacts with PATJ.

neXtProt entry for KCNJ15 Gene

Post-translational modifications for KCNJ15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for KCNJ15 Gene

Domains & Families for KCNJ15 Gene

Gene Families for KCNJ15 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNJ15 Gene

Graphical View of Domain Structure for InterPro Entry

Q99712

UniProtKB/Swiss-Prot:

KCJ15_HUMAN :
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
Family:
  • Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
genes like me logo Genes that share domains with KCNJ15: view

Function for KCNJ15 Gene

Molecular function for KCNJ15 Gene

GENATLAS Biochemistry:
potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
UniProtKB/Swiss-Prot Function:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Phenotypes From GWAS Catalog for KCNJ15 Gene

Gene Ontology (GO) - Molecular Function for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 8995301
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005515 protein binding IPI 9647694
GO:0015467 G-protein activated inward rectifier potassium channel activity TAS --
genes like me logo Genes that share ontologies with KCNJ15: view
genes like me logo Genes that share phenotypes with KCNJ15: view

Animal Models for KCNJ15 Gene

MGI Knock Outs for KCNJ15:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNJ15 Gene

Localization for KCNJ15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNJ15 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8995301
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNJ15: view

Pathways & Interactions for KCNJ15 Gene

genes like me logo Genes that share pathways with KCNJ15: view

Gene Ontology (GO) - Biological Process for KCNJ15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 8995301
GO:0010107 potassium ion import IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNJ15: view

No data available for SIGNOR curated interactions for KCNJ15 Gene

Drugs & Compounds for KCNJ15 Gene

(7) Drugs for KCNJ15 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Yohimbine Approved, Investigational, Vet_approved Pharma Antagonist, Target 28
Magnesium Approved Nutra 0
Glyburide Approved Pharma Channel blocker Kir6 (KATP) channel blocker 116
Nicorandil Approved, Investigational Pharma Activator Potassium channel activator, Kir6 (KATP) channel opener and NO donor 19

(5) Tocris Compounds for KCNJ15 Gene

Compound Action Cas Number
Glibenclamide Kir6 (KATP) channel blocker 10238-21-8
Minoxidil Kir6 channel (KATP) opener 38304-91-5
Nicorandil Kir6 (KATP) channel opener and NO donor 65141-46-0
P1075 Potent Kir6 (KATP) channel opener 60559-98-0
ZM 226600 Kir6 (KATP) channel opener 147695-92-9
genes like me logo Genes that share compounds with KCNJ15: view

Transcripts for KCNJ15 Gene

Unigene Clusters for KCNJ15 Gene

Potassium inwardly-rectifying channel, subfamily J, member 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7:
SP8: -

Relevant External Links for KCNJ15 Gene

GeneLoc Exon Structure for
KCNJ15
ECgene alternative splicing isoforms for
KCNJ15

Expression for KCNJ15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNJ15 Gene

mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene

This gene is overexpressed in Whole Blood (x26.9) and Kidney - Cortex (x7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNJ15 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCNJ15 Gene:

KCNJ15

SOURCE GeneReport for Unigene cluster for KCNJ15 Gene:

Hs.411299

Evidence on tissue expression from TISSUES for KCNJ15 Gene

  • Kidney(4.7)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with KCNJ15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNJ15 Gene

Orthologs for KCNJ15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNJ15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNJ15 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia KCNJ15 33 34
  • 90.4 (n)
cow
(Bos Taurus)
Mammalia KCNJ15 33 34
  • 89.07 (n)
rat
(Rattus norvegicus)
Mammalia Kcnj15 33
  • 86.22 (n)
mouse
(Mus musculus)
Mammalia Kcnj15 33 16 34
  • 85.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNJ15 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNJ15 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNJ15 33 34
  • 78.04 (n)
lizard
(Anolis carolinensis)
Reptilia KCNJ15 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnj15 33
  • 70.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68935 33
zebrafish
(Danio rerio)
Actinopterygii LOC572476 33
  • 65.74 (n)
KCNJ15 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Irk3 35
  • 34 (a)
Irk2 34
  • 29 (a)
ManyToMany
Ir 34
  • 24 (a)
ManyToMany
Species where no ortholog for KCNJ15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNJ15 Gene

ENSEMBL:
Gene Tree for KCNJ15 (if available)
TreeFam:
Gene Tree for KCNJ15 (if available)

Paralogs for KCNJ15 Gene

Variants for KCNJ15 Gene

Sequence variations from dbSNP and Humsavar for KCNJ15 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs199857043 A breast cancer sample 38,299,472(+) G/A coding_sequence_variant, missense_variant
rs1000013062 -- 38,253,773(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000020096 -- 38,234,878(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000058461 -- 38,251,499(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000080825 -- 38,247,133(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNJ15 Gene

Variant ID Type Subtype PubMed ID
esv22065 CNV loss 19812545
esv2677092 CNV deletion 23128226
esv33823 CNV loss 17666407
esv3387523 CNV insertion 20981092
esv3389609 CNV insertion 20981092
esv3647000 CNV loss 21293372
nsv1058886 CNV gain 25217958
nsv3514 CNV insertion 18451855
nsv474591 CNV novel sequence insertion 20440878
nsv819873 CNV loss 19587683

Variation tolerance for KCNJ15 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNJ15 Gene

Human Gene Mutation Database (HGMD)
KCNJ15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNJ15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ15 Gene

Disorders for KCNJ15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KCNJ15 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNJ15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KCNJ15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNJ15 Gene

Publications for KCNJ15 Gene

  1. A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P … Créau N (Genomics 1997) 2 3 4 22 58
  2. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck ME … Bienkowski MJ (The Journal of biological chemistry 1997) 2 3 4 58
  3. Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (PMID: 20085713) Okamoto K … Tokunaga K (American journal of human genetics 2010) 3 44 58
  4. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y … Vandenberg CA (Pharmacological reviews 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KCNJ15 Gene

Sources for KCNJ15 Gene

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