Aliases for KCNJ10 Gene
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 10 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 10 3 4
- ATP-Dependent Inwardly Rectifying Potassium Channel Kir4.1 3 4
- Inward Rectifier K(+) Channel Kir1.2 3 4
- SESAME 3 6
- Glial ATP-Dependent Inwardly Rectifying Potassium Channel KIR4.1 3
External Ids for KCNJ10 Gene
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNJ10 Gene
KCNJ10 (Potassium Channel, Inwardly Rectifying Subfamily J, Member 10) is a Protein Coding gene. Diseases associated with KCNJ10 include sesame syndrome and kcnj10-related pendred syndrome. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. GO annotations related to this gene include identical protein binding and ATP-activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.
UniProtKB/Swiss-Prot for KCNJ10 Gene
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. KIR3.2 with KIR3.3.