Aliases for KCNJ8 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 8 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 8 3 5
- Potassium Channel, Inwardly Rectifying Subfamily J Member 8 3 4
- Inward Rectifier K(+) Channel Kir6.1 3 4
- UKATP-1 3 4
- Inwardly Rectifying Potassium Channel KIR6.1 3
- KIR6.1 3
External Ids for KCNJ8 Gene
Previous GeneCards Identifiers for KCNJ8 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]
GeneCards Summary for KCNJ8 Gene
KCNJ8 (Potassium Voltage-Gated Channel Subfamily J Member 8) is a Protein Coding gene. Diseases associated with KCNJ8 include Hypertrichotic Osteochondrodysplasia, Cantu Type and Hypertrichotic Osteochondrodysplasia. Among its related pathways are Inwardly rectifying K+ channels and Transmission across Chemical Synapses. GO annotations related to this gene include inward rectifier potassium channel activity and ATP-activated inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3.
UniProtKB/Swiss-Prot for KCNJ8 Gene
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.