Aliases for KCNE1 Gene
- Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 1 2 3
- IKs Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink 3 4
- Potassium Voltage-Gated Channel, Isk-Related Family, Member 1 2 3
- Delayed Rectifier Potassium Channel Subunit IsK 3 4
- Minimal Potassium Channel 3 4
- JLNS2 3 6
- LQT5 3 6
- JLNS 3 6
External Ids for KCNE1 Gene
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNE1 Gene
KCNE1 (Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNE1 include jervell and lange-nielsen syndrome 2 and long qt syndrome 5. Among its related pathways are Adrenergic signaling in cardiomyocytes and Antiarrhythmic Pathway, Pharmacodynamics. GO annotations related to this gene include voltage-gated potassium channel activity and potassium channel regulator activity.
UniProtKB/Swiss-Prot for KCNE1 Gene
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr)
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.