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Aliases for KCNC2 Gene

Aliases for KCNC2 Gene

  • Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 2 2 3
  • Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 2 3
  • Voltage-Gated Potassium Channel Kv3.2 3 4
  • Potassium Voltage-Gated Channel Subfamily C Member 2 3
  • KV3.2 3

External Ids for KCNC2 Gene

Previous GeneCards Identifiers for KCNC2 Gene

  • GC12P074022
  • GC12M075342
  • GC12M075150
  • GC12M073720
  • GC12M075433
  • GC12M072483

Summaries for KCNC2 Gene

Entrez Gene Summary for KCNC2 Gene

  • The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for KCNC2 Gene

KCNC2 (Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transmission across Chemical Synapses. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNC2 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity).

Tocris Summary for KCNC2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNC2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNC2 Gene

Genomics for KCNC2 Gene

Regulatory Elements for KCNC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KCNC2 Gene

Start:
75,040,077 bp from pter
End:
75,209,868 bp from pter
Size:
169,792 bases
Orientation:
Minus strand

Genomic View for KCNC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNC2 Gene

Proteins for KCNC2 Gene

  • Protein details for KCNC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PR1-KCNC2_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily C member 2
    Protein Accession:
    Q96PR1
    Secondary Accessions:
    • B7Z231
    • F5H030
    • J3KPP5
    • Q4LE77
    • Q86W09
    • Q8N1V9
    • Q96PR0

    Protein attributes for KCNC2 Gene

    Size:
    638 amino acids
    Molecular mass:
    70226 Da
    Quaternary structure:
    • The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits. Interacts with KCNC1, KCNE1, KCNE2 and KCNE3 (By similarity).
    SequenceCaution:
    • Sequence=BAE06076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNC2 Gene

neXtProt entry for KCNC2 Gene

Proteomics data for KCNC2 Gene at MOPED

Post-translational modifications for KCNC2 Gene

  • Glycosylation at Asn259 and Asn266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCNC2 Gene

Domains for KCNC2 Gene

Gene Families for KCNC2 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

Suggested Antigen Peptide Sequences for KCNC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PR1

UniProtKB/Swiss-Prot:

KCNC2_HUMAN :
  • Q96PR1
Domain:
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position
  • The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments
Family:
  • Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily.
genes like me logo Genes that share domains with KCNC2: view

Function for KCNC2 Gene

Molecular function for KCNC2 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila Shaw-related subfamily,member 2 (mouse Kv3.2 homolog)
UniProtKB/Swiss-Prot Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity).

Gene Ontology (GO) - Molecular Function for KCNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005249 voltage-gated potassium channel activity ISS --
GO:0005251 delayed rectifier potassium channel activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNC2: view

Phenotypes for KCNC2 Gene

genes like me logo Genes that share phenotypes with KCNC2: view

Animal Models for KCNC2 Gene

MGI Knock Outs for KCNC2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNC2 Gene

Localization for KCNC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNC2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNC2 Gene COMPARTMENTS Subcellular localization image for KCNC2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for KCNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0008076 voltage-gated potassium channel complex ISS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNC2: view

Pathways for KCNC2 Gene

genes like me logo Genes that share pathways with KCNC2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KCNC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001508 action potential IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNC2: view

Compounds for KCNC2 Gene

(5) Tocris Compounds for KCNC2 Gene

Compound Action Cas Number
4-Aminopyridine Non-selective KV channel blocker [504-24-5]
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
Margatoxin Potent KV1.3 channel blocker [145808-47-5]
MaxiPost Potassium channel modulator; exerts subtype-specific effects [187523-35-9]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents [122955-13-9]

(3) IUPHAR Ligand for KCNC2 Gene

Ligand Type Action Affinity Pubmed IDs
ShK Toxin Pore Blocker None 9.5
4-aminopyridine Inhibitor None
tetraethylammonium Inhibitor None
genes like me logo Genes that share compounds with KCNC2: view

Transcripts for KCNC2 Gene

Unigene Clusters for KCNC2 Gene

Potassium voltage-gated channel, Shaw-related subfamily, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KCNC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KCNC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNC2 Gene

No ASD Table

Relevant External Links for KCNC2 Gene

GeneLoc Exon Structure for
KCNC2
ECgene alternative splicing isoforms for
KCNC2

Expression for KCNC2 Gene

mRNA expression in normal human tissues for KCNC2 Gene

mRNA differential expression in normal tissues according to GTEx for KCNC2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (12.6), Brain - Anterior cingulate cortex (BA24) (12.3), Brain - Cortex (8.5), and Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KCNC2 Gene

SOURCE GeneReport for Unigene cluster for KCNC2 Gene Hs.27214

genes like me logo Genes that share expressions with KCNC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNC2 Gene

Orthologs for KCNC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNC2 35
  • 99.17 (n)
  • 99.23 (a)
KCNC2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNC2 35
  • 91.67 (n)
  • 94.55 (a)
KCNC2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnc2 35
  • 89.51 (n)
  • 97.47 (a)
Kcnc2 16
Kcnc2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNC2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kcnc2 35
  • 90.28 (n)
  • 97.65 (a)
chicken
(Gallus gallus)
Aves KCNC2 35
  • 85.49 (n)
  • 91.96 (a)
KCNC2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNC2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnc2 35
  • 78.27 (n)
  • 87.67 (a)
zebrafish
(Danio rerio)
Actinopterygii kcnc2 35
  • 70.09 (n)
  • 77.78 (a)
kcnc2 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008200 35
  • 58.39 (n)
  • 54.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shaw 35
  • 60.12 (n)
  • 55.14 (a)
Shaw 37
  • 47 (a)
CG4450 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea shw-1 35
  • 54.36 (n)
  • 51.17 (a)
shw-3 37
  • 42 (a)
Species with no ortholog for KCNC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNC2 Gene

ENSEMBL:
Gene Tree for KCNC2 (if available)
TreeFam:
Gene Tree for KCNC2 (if available)

Paralogs for KCNC2 Gene

Selected SIMAP similar genes for KCNC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNC2: view

Variants for KCNC2 Gene

Sequence variations from dbSNP and Humsavar for KCNC2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs716955 -- 75,199,692(-) ATGAC(A/T)GGTGA intron-variant
rs721749 -- 75,143,075(+) GGGTC(C/T)GTCTC intron-variant
rs721750 -- 75,142,808(+) GGTTG(C/T)CTTTT intron-variant
rs735636 -- 75,171,943(+) TATCA(C/T)TTGTT intron-variant
rs735637 -- 75,171,955(+) TCTTC(G/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KCNC2 Gene

Variant ID Type Subtype PubMed ID
nsv899307 CNV Loss 21882294
nsv522290 CNV Gain 19592680
nsv899308 CNV Loss 21882294
nsv832462 CNV Gain 17160897
nsv519821 CNV Loss 19592680

Relevant External Links for KCNC2 Gene

HapMap Linkage Disequilibrium report
KCNC2
Human Gene Mutation Database (HGMD)
KCNC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNC2 Gene

Disorders for KCNC2 Gene

No disorders were found for KCNC2 Gene.

No data available for UniProtKB/Swiss-Prot for KCNC2 Gene

Publications for KCNC2 Gene

  1. Localization of Shaw-related K+ channel genes on mouse and human chromosomes. (PMID: 8111118) Haas M. … Rudy B. (Mamm. Genome 1993) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  4. Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore. (PMID: 19332619) Wang Z. … Fedida D. (J. Gen. Physiol. 2009) 3
  5. Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease. (PMID: 21912965) Boda E. … Tempia F. (J. Mol. Neurosci. 2012) 3

Products for KCNC2 Gene

Sources for KCNC2 Gene

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