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Aliases for KCNA7 Gene

Aliases for KCNA7 Gene

  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 7 2 3
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 7 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.7 3 4
  • Potassium Voltage-Gated Channel Subfamily A Member 7 3
  • Voltage-Dependent Potassium Channel Kv1.7 3
  • Voltage-Gated Potassium Channel KCNA7 3
  • KV1.7 3
  • HAK6 3

External Ids for KCNA7 Gene

Summaries for KCNA7 Gene

Entrez Gene Summary for KCNA7 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA7 Gene

KCNA7 (Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 7) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include delayed rectifier potassium channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA7 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).

Tocris Summary for KCNA7 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

Gene Wiki entry for KCNA7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA7 Gene

Genomics for KCNA7 Gene

Genomic Location for KCNA7 Gene

Start:
49,067,418 bp from pter
End:
49,072,941 bp from pter
Size:
5,524 bases
Orientation:
Minus strand

Genomic View for KCNA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KCNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA7 Gene

Regulatory Elements for KCNA7 Gene

Proteins for KCNA7 Gene

  • Protein details for KCNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RP8-KCNA7_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 7
    Protein Accession:
    Q96RP8
    Secondary Accessions:
    • A1KYX7
    • Q9BYS4

    Protein attributes for KCNA7 Gene

    Size:
    456 amino acids
    Molecular mass:
    50559 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins.

neXtProt entry for KCNA7 Gene

Proteomics data for KCNA7 Gene at MOPED

Post-translational modifications for KCNA7 Gene

Other Protein References for KCNA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNA7 Gene

Domains for KCNA7 Gene

Gene Families for KCNA7 Gene

HGNC:
  • KCN :Potassium channels
  • Kv :Voltage-gated ion channels / Potassium channels
IUPHAR :

UniProtKB/Swiss-Prot:

KCNA7_HUMAN
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.:
    • Q96RP8
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.:
    • Q96RP8
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.:
    • Q96RP8
genes like me logo Genes that share domains with KCNA7: view

Function for KCNA7 Gene

Molecular function for KCNA7 Gene

GENATLAS Biochemistry: potassium voltage-gated channel,Drosophila shaker-related subfamily,member 7 (mouse Kv1.7 homolog),expressed in heart,skeletal muscle and pancreatic islet cells
UniProtKB/Swiss-Prot Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).

Gene Ontology (GO) - Molecular Function for KCNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005251 delayed rectifier potassium channel activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KCNA7: view

Phenotypes for KCNA7 Gene

GenomeRNAi human phenotypes for KCNA7:
genes like me logo Genes that share phenotypes with KCNA7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KCNA7 Gene

Localization for KCNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA7 Gene COMPARTMENTS Subcellular localization image for KCNA7 gene
Compartment Confidence
plasma membrane 4
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 voltage-gated potassium channel complex IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with KCNA7: view

Pathways for KCNA7 Gene

genes like me logo Genes that share pathways with KCNA7: view

Pathways by source for KCNA7 Gene

1 Qiagen pathway for KCNA7 Gene

Interacting Proteins for KCNA7 Gene

Gene Ontology (GO) - Biological Process for KCNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0007268 synaptic transmission TAS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with KCNA7: view

Compounds for KCNA7 Gene

(5) Tocris Compounds for KCNA7 Gene

Compound Action Cas Number
E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) [113559-13-0]
ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties [325457-99-6]
JNJ 303 Potent and selective IKs blocker [878489-28-2]
ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro [220384-25-8]
XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-current [122955-42-4]

(5) IUPHAR Ligand for KCNA7 Gene

Ligand Type Action Affinity Pubmed IDs
flecainide Pore Blocker None 5.1
amiodarone Pore Blocker None 4.5
quinidine Inhibitor Inhibition
verapamil Inhibitor Inhibition
tetraethylammonium Inhibitor None
genes like me logo Genes that share compounds with KCNA7: view

Transcripts for KCNA7 Gene

mRNA/cDNA for KCNA7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA7 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA7 Gene

No ASD Table

Relevant External Links for KCNA7 Gene

GeneLoc Exon Structure for
KCNA7
ECgene alternative splicing isoforms for
KCNA7

Expression for KCNA7 Gene

mRNA expression in normal human tissues for KCNA7 Gene

mRNA differential expression in normal tissues according to GTEx for KCNA7 Gene

This gene is overexpressed in Muscle - Skeletal (46.6).

SOURCE GeneReport for Unigene cluster for KCNA7 Gene Hs.306973

mRNA Expression by UniProt/SwissProt for KCNA7 Gene

Q96RP8-KCNA7_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, heart and kidney.
genes like me logo Genes that share expressions with KCNA7: view

Orthologs for KCNA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNA7 36
  • 99.08 (n)
  • 98.62 (a)
KCNA7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNA7 36
  • 88.94 (n)
  • 92.83 (a)
KCNA7 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA7 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna7 36
  • 86.35 (n)
  • 93.44 (a)
Kcna7 16
Kcna7 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNA7 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA7 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcna7 36
  • 86.43 (n)
  • 93.44 (a)
lizard
(Anolis carolinensis)
Reptilia KCNA7 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 42 (a)
OneToMany
Sh 38
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 38
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
Species with no ortholog for KCNA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for KCNA7 Gene

ENSEMBL:
Gene Tree for KCNA7 (if available)
TreeFam:
Gene Tree for KCNA7 (if available)

Paralogs for KCNA7 Gene

Selected SIMAP similar genes for KCNA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCNA7: view

Variants for KCNA7 Gene

Sequence variations from dbSNP and Humsavar for KCNA7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1017219 - 49,070,181(+) GCTGC(A/G)TGTCC missense, reference
rs1611775 - 49,070,868(-) CGCTC(C/G)GCTGA reference, missense
rs3810185 -- 49,069,572(+) CTCAA(C/T)GAAAC utr-variant-3-prime
rs3810186 -- 49,069,755(+) TGATA(C/T)GACCA utr-variant-3-prime
rs3810188 -- 49,070,261(+) ATGAC(A/G)GGCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KCNA7 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
nsv912252 CNV Loss 21882294
nsv520785 CNV Gain 19592680
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912256 CNV Loss 21882294
nsv912257 CNV Loss 21882294
nsv828577 CNV Gain 20364138

Relevant External Links for KCNA7 Gene

HapMap Linkage Disequilibrium report
KCNA7

Disorders for KCNA7 Gene

Relevant External Links for KCNA7

Genetic Association Database (GAD)
KCNA7
Human Genome Epidemiology (HuGE) Navigator
KCNA7
genes like me logo Genes that share disorders with KCNA7: view

No data available for UniProtKB/Swiss-Prot for KCNA7 Gene

Publications for KCNA7 Gene

  1. Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. (PMID: 11368907) Kashuba V.I. … Zabarovsky E.R. (Gene 2001) 3 4 23
  2. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). (PMID: 11896454) Bardien-Kruger S. … Corfield V. (Eur. J. Hum. Genet. 2002) 3 4 23
  3. [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]. (PMID: 15639836) Ding Q. … Guo L. (Yi Chuan 2003) 3 49
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. (PMID: 9488722) Kalman K. … Chandy K.G. (J. Biol. Chem. 1998) 3 23

Products for KCNA7 Gene

Sources for KCNA7 Gene

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