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Aliases for KCNA3 Gene

Aliases for KCNA3 Gene

  • Potassium Voltage-Gated Channel Subfamily A Member 3 2 3
  • Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3 3 5
  • Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 2 3
  • Voltage-Gated Potassium Channel Subunit Kv1.3 3 4
  • Voltage-Gated K(+) Channel HuKIII 3 4
  • HPCN3 3 4
  • HGK5 3 4
  • HLK3 3 4
  • Voltage-Gated Potassium Channel Protein Kv1.3 3
  • Type N Potassium Channel 3
  • Potassium Channel 3 3
  • Potassium Channel 2
  • HUKIII 3
  • KV1.3 3
  • PCN3 3
  • MK3 3

External Ids for KCNA3 Gene

Previous GeneCards Identifiers for KCNA3 Gene

  • GC01M111630
  • GC01M110080
  • GC01M110316
  • GC01M110513
  • GC01M110926
  • GC01M111015
  • GC01M111214
  • GC01M109085

Summaries for KCNA3 Gene

Entrez Gene Summary for KCNA3 Gene

  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNA3 Gene

KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include lymph node cancer. Among its related pathways are Transmission across Chemical Synapses and Potassium Channels. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNA10.

UniProtKB/Swiss-Prot for KCNA3 Gene

  • Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Tocris Summary for KCNA3 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNA3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNA3 Gene

Genomics for KCNA3 Gene

Regulatory Elements for KCNA3 Gene

Promoters for KCNA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KCNA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KCNA3 Gene

Chromosome:
1
Start:
110,653,560 bp from pter
End:
110,675,033 bp from pter
Size:
21,474 bases
Orientation:
Minus strand

Genomic View for KCNA3 Gene

Genes around KCNA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNA3 Gene

Proteins for KCNA3 Gene

  • Protein details for KCNA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22001-KCNA3_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily A member 3
    Protein Accession:
    P22001
    Secondary Accessions:
    • Q5VWN2

    Protein attributes for KCNA3 Gene

    Size:
    575 amino acids
    Molecular mass:
    63842 Da
    Quaternary structure:
    • Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
    SequenceCaution:
    • Sequence=AAA36425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36425.1; Type=Frameshift; Positions=42; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA59457.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAB88073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC31761.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCNA3 Gene

neXtProt entry for KCNA3 Gene

Proteomics data for KCNA3 Gene at MOPED

Post-translational modifications for KCNA3 Gene

Other Protein References for KCNA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KCNA3 Gene

Domains & Families for KCNA3 Gene

Gene Families for KCNA3 Gene

Suggested Antigen Peptide Sequences for KCNA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22001

UniProtKB/Swiss-Prot:

KCNA3_HUMAN :
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
Domain:
  • The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  • The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Family:
  • Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
genes like me logo Genes that share domains with KCNA3: view

Function for KCNA3 Gene

Molecular function for KCNA3 Gene

GENATLAS Biochemistry:
potassium voltage-gated channel,Drosophila shaker-related subfamily,member 3,T cell (mouse Kv1.3 homolog)
UniProtKB/Swiss-Prot Function:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Gene Ontology (GO) - Molecular Function for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with KCNA3: view
genes like me logo Genes that share phenotypes with KCNA3: view

Animal Models for KCNA3 Gene

MGI Knock Outs for KCNA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCNA3 Gene

Localization for KCNA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNA3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KCNA3 Gene COMPARTMENTS Subcellular localization image for KCNA3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KCNA3: view

Pathways & Interactions for KCNA3 Gene

genes like me logo Genes that share pathways with KCNA3: view

Pathways by source for KCNA3 Gene

1 BioSystems pathway for KCNA3 Gene
1 Qiagen pathway for KCNA3 Gene

SIGNOR curated interactions for KCNA3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNA3: view

Drugs & Compounds for KCNA3 Gene

(7) Drugs for KCNA3 Gene - From: IUPHAR, DGIdb, Tocris, Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dalfampridine Approved Pharma Pore Blocker, Target, antagonist 62
Potassium Experimental Pharma 0
tetraethylammonium Experimental Pharma Inhibitor 1
charybdotoxin Pharma Pore Blocker, blocker 0
correolide Pharma Pore Blocker 0

(5) Additional Compounds for KCNA3 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
noxiustoxin
Inhibitor
L-364,373
103342-82-1
NS 1643
448895-37-2
NS 5806
426834-69-7
PD 118057
313674-97-4

(5) Tocris Compounds for KCNA3 Gene

Compound Action Cas Number
Flupirtine maleate KV7 channel activator 75507-68-5
L-364,373 KV7.1 channel activator, activates IKs 103342-82-1
NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic 448895-37-2
NS 5806 KV4.3 channel activator 426834-69-7
PD 118057 Selective KV11.1 (hERG) channel activator 313674-97-4
genes like me logo Genes that share compounds with KCNA3: view

Transcripts for KCNA3 Gene

mRNA/cDNA for KCNA3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNA3 Gene

Potassium voltage-gated channel, shaker-related subfamily, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KCNA3 Gene

No ASD Table

Relevant External Links for KCNA3 Gene

GeneLoc Exon Structure for
KCNA3
ECgene alternative splicing isoforms for
KCNA3

Expression for KCNA3 Gene

mRNA expression in normal human tissues for KCNA3 Gene

mRNA differential expression in normal tissues according to GTEx for KCNA3 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for KCNA3 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KCNA3 Gene



SOURCE GeneReport for Unigene cluster for KCNA3 Gene Hs.169948

genes like me logo Genes that share expression patterns with KCNA3: view

Protein tissue co-expression partners for KCNA3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KCNA3 Gene

Orthologs for KCNA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KCNA3 35
  • 92.12 (n)
  • 95.13 (a)
KCNA3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNA3 35
  • 91.05 (n)
  • 95.14 (a)
KCNA3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kcna3 35
  • 89.74 (n)
  • 96.18 (a)
Kcna3 16
Kcna3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KCNA3 35
  • 99.59 (n)
  • 99.3 (a)
KCNA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kcna3 35
  • 90.31 (n)
  • 96.37 (a)
oppossum
(Monodelphis domestica)
Mammalia KCNA3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNA3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNA3 35
  • 76.26 (n)
  • 83.63 (a)
CKV1.1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNA3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcna1 35
  • 75.6 (n)
  • 84.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia kcna3b-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330283 35
  • 73.41 (n)
  • 84.05 (a)
KCNA3 (1 of 2) 36
  • 86 (a)
OneToMany
KCNA3 (2 of 2) 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sh 37
  • 70 (a)
Sh 35
  • 60.57 (n)
  • 73.15 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000254 35
  • 61.83 (n)
  • 73.27 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3C.3 37
  • 30 (a)
shk-1 35
  • 53.35 (n)
  • 50.13 (a)
Species with no ortholog for KCNA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNA3 Gene

ENSEMBL:
Gene Tree for KCNA3 (if available)
TreeFam:
Gene Tree for KCNA3 (if available)

Paralogs for KCNA3 Gene

(19) SIMAP similar genes for KCNA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNA3: view

Variants for KCNA3 Gene

Sequence variations from dbSNP and Humsavar for KCNA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs361501 -- 110,674,606(-) GCCGA(C/T)GGTGG upstream-variant-2KB, reference, synonymous-codon
rs1058184 -- 110,672,850(-) TCTCT(G/T)AACAT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1058185 -- 110,672,687(-) TCAAT(C/T)CGTAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1058186 -- 110,672,621(-) GGTGT(C/G)CCTAC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1156237 -- 110,668,587(-) TATTT(C/T)TAAAC intron-variant

Variation tolerance for KCNA3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KCNA3 Gene

HapMap Linkage Disequilibrium report
KCNA3
Human Gene Mutation Database (HGMD)
KCNA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KCNA3 Gene

Disorders for KCNA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymph node cancer
  • lymph node neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search KCNA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KCNA3

Genetic Association Database (GAD)
KCNA3
Human Genome Epidemiology (HuGE) Navigator
KCNA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KCNA3
genes like me logo Genes that share disorders with KCNA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNA3 Gene

Publications for KCNA3 Gene

  1. A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance. (PMID: 16317062) Tschritter O. … Fritsche A. (J. Clin. Endocrinol. Metab. 2006) 3 23 48 67
  2. Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. (PMID: 19574640) Winklmeier A. … Kremer W. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 23
  3. Methyl-beta-cyclodextrin reversibly alters the gating of lipid rafts-associated Kv1.3 channels in Jurkat T lymphocytes. (PMID: 17242956) Pottosin I.I. … Dobrovinskaya O.R. (Pflugers Arch. 2007) 3 23
  4. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman G.A. … Wang X. (Pharmacol. Rev. 2005) 2 3
  5. Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PMID: 7829094) Folander K. … Swanson R. (Genomics 1994) 3 23

Products for KCNA3 Gene

Sources for KCNA3 Gene

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