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Aliases for GSTK1 Gene

Aliases for GSTK1 Gene

  • Glutathione S-Transferase Kappa 1 2 3
  • GST Class-Kappa 3 4
  • GST 13-13 3 4
  • GSTK1-1 3 4
  • HGSTK1 3 4
  • Glutathione S-Transferase Subunit 13 Homolog 3
  • Glutathione S-Transferase Subunit 13 4
  • Glutathione S-Transferase K1 3
  • EC 2.5.1.18 4
  • GST13-13 3
  • GST13 3
  • GST 3

External Ids for GSTK1 Gene

Previous GeneCards Identifiers for GSTK1 Gene

  • GC00U913601
  • GC07U901487
  • GC07P142477
  • GC07P142670
  • GC07P142942
  • GC07P137297

Summaries for GSTK1 Gene

Entrez Gene Summary for GSTK1 Gene

  • This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GeneCards Summary for GSTK1 Gene

GSTK1 (Glutathione S-Transferase Kappa 1) is a Protein Coding gene. Among its related pathways are Chemical carcinogenesis and Peroxisome. GO annotations related to this gene include receptor binding and glutathione transferase activity.

UniProtKB/Swiss-Prot for GSTK1 Gene

  • Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)

Gene Wiki entry for GSTK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTK1 Gene

Genomics for GSTK1 Gene

Regulatory Elements for GSTK1 Gene

Genomic Location for GSTK1 Gene

Start:
143,244,093 bp from pter
End:
143,270,854 bp from pter
Size:
26,762 bases
Orientation:
Plus strand

Genomic View for GSTK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTK1 Gene

Proteins for GSTK1 Gene

  • Protein details for GSTK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Q3-GSTK1_HUMAN
    Recommended name:
    Glutathione S-transferase kappa 1
    Protein Accession:
    Q9Y2Q3
    Secondary Accessions:
    • B4DIH1
    • B4DSY2
    • Q6P4H0
    • Q7Z520
    • Q9P1S4

    Protein attributes for GSTK1 Gene

    Size:
    226 amino acids
    Molecular mass:
    25497 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTK1 Gene

    Alternative splice isoforms for GSTK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTK1 Gene

Proteomics data for GSTK1 Gene at MOPED

Post-translational modifications for GSTK1 Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GSTK1 Gene

Domains for GSTK1 Gene

Gene Families for GSTK1 Gene

HGNC:
  • GSTK :Glutathione S-transferases / Mitochondrial (kappa)

Protein Domains for GSTK1 Gene

Suggested Antigen Peptide Sequences for GSTK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2Q3

UniProtKB/Swiss-Prot:

GSTK1_HUMAN :
  • Q9Y2Q3
Family:
  • Belongs to the GST superfamily. Kappa family.
genes like me logo Genes that share domains with GSTK1: view

Function for GSTK1 Gene

Molecular function for GSTK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot Function: Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)

Enzyme Numbers (IUBMB) for GSTK1 Gene

Gene Ontology (GO) - Molecular Function for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 14742434
GO:0004602 glutathione peroxidase activity IDA 14742434
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 25416956
GO:0015035 protein disulfide oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GSTK1: view
genes like me logo Genes that share phenotypes with GSTK1: view

Animal Models for GSTK1 Gene

MGI Knock Outs for GSTK1:

miRNA for GSTK1 Gene

miRTarBase miRNAs that target GSTK1

No data available for Transcription Factor Targeting and HOMER Transcription for GSTK1 Gene

Localization for GSTK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTK1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTK1 Gene COMPARTMENTS Subcellular localization image for GSTK1 gene
Compartment Confidence
peroxisome 5
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0005777 peroxisome IDA 14742434
genes like me logo Genes that share ontologies with GSTK1: view

Pathways for GSTK1 Gene

genes like me logo Genes that share pathways with GSTK1: view

Pathways by source for GSTK1 Gene

Gene Ontology (GO) - Biological Process for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IEA --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GSTK1: view

Compounds for GSTK1 Gene

(9) HMDB Compounds for GSTK1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(2) Drugbank Compounds for GSTK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
GLUTATHIONE SULFINATE
target
genes like me logo Genes that share compounds with GSTK1: view

Transcripts for GSTK1 Gene

Unigene Clusters for GSTK1 Gene

Glutathione S-transferase kappa 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for GSTK1 Gene

GeneLoc Exon Structure for
GSTK1
ECgene alternative splicing isoforms for
GSTK1

Expression for GSTK1 Gene

mRNA expression in normal human tissues for GSTK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTK1 Gene

SOURCE GeneReport for Unigene cluster for GSTK1 Gene Hs.390667

mRNA Expression by UniProt/SwissProt for GSTK1 Gene

Q9Y2Q3-GSTK1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with GSTK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GSTK1 Gene

Orthologs for GSTK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTK1 35
  • 96.61 (n)
  • 95.13 (a)
GSTK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSTK1 35
  • 81.71 (n)
  • 75.22 (a)
GSTK1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
GSTK1 35
  • 86.43 (n)
  • 83.63 (a)
mouse
(Mus musculus)
Mammalia Gstk1 35
  • 73.3 (n)
  • 64.16 (a)
Gstk1 16
Gstk1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GSTK1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstk1 35
  • 76.99 (n)
  • 69.03 (a)
chicken
(Gallus gallus)
Aves GSTK1 35
  • 62.81 (n)
  • 57.41 (a)
GSTK1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTK1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstk1 35
  • 61.99 (n)
  • 59.81 (a)
zebrafish
(Danio rerio)
Actinopterygii gstk1 35
  • 56.54 (n)
  • 51.87 (a)
gstk1 36
  • 48 (a)
OneToMany
GSTK1 (1 of 4) 36
  • 41 (a)
OneToMany
GSTK1 (3 of 4) 36
  • 43 (a)
OneToMany
GSTK1 (4 of 4) 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gstk-1 35
  • 46.57 (n)
  • 34.45 (a)
gstk-1 36
  • 29 (a)
OneToMany
gstk-2 36
  • 30 (a)
OneToMany
Species with no ortholog for GSTK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTK1 Gene

ENSEMBL:
Gene Tree for GSTK1 (if available)
TreeFam:
Gene Tree for GSTK1 (if available)

Paralogs for GSTK1 Gene

Selected SIMAP similar genes for GSTK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GSTK1: view

No data available for Paralogs for GSTK1 Gene

Variants for GSTK1 Gene

Sequence variations from dbSNP and Humsavar for GSTK1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1043436 -- 143,268,863(+) CTCTT(C/G)GTATA utr-variant-3-prime
rs1917760 -- 143,262,206(+) AGCAG(G/T)ACAGT upstream-variant-2KB
rs2367807 -- 143,266,646(+) TTTTC(C/T)TTCCt intron-variant
rs2367808 -- 143,266,650(+) CTTTC(C/T)ttctt intron-variant
rs7458960 -- 143,262,748(+) caagg(C/G)gctag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSTK1 Gene

Variant ID Type Subtype PubMed ID
nsv831169 CNV Loss 17160897
esv2735280 CNV Deletion 23290073

Relevant External Links for GSTK1 Gene

HapMap Linkage Disequilibrium report
GSTK1
Human Gene Mutation Database (HGMD)
GSTK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTK1 Gene

Disorders for GSTK1 Gene

Relevant External Links for GSTK1

Genetic Association Database (GAD)
GSTK1
Human Genome Epidemiology (HuGE) Navigator
GSTK1
genes like me logo Genes that share disorders with GSTK1: view

No data available for UniProtKB/Swiss-Prot for GSTK1 Gene

Publications for GSTK1 Gene

  1. Gene and protein characterization of the human glutathione S- transferase kappa and evidence for a peroxisomal localization. (PMID: 14742434) Morel F. … Guillouzo A. (J. Biol. Chem. 2004) 2 3 4 23
  2. Modelling and bioinformatics studies of the human kappa class glutathione transferase predict a novel third glutathione transferase family with homology to prokaryotic 2-hydroxychromene-2-carboxylate (HCCA) isomerases. (PMID: 14709161) Robinson A. … Board P.G. (Biochem. J. 2004) 3 4 23 25
  3. Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. (PMID: 16081649) Li J. … Ding J. (Protein Sci. 2005) 3 4
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48
  5. Analysis of the glutathione S-transferase (GST) gene family. (PMID: 15607001) Nebert D.W. … Vasiliou V. (Hum. Genomics 2004) 3 23

Products for GSTK1 Gene

Sources for GSTK1 Gene

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