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Aliases for TRIM23 Gene

Aliases for TRIM23 Gene

  • Tripartite Motif Containing 23 2 3
  • ADP-Ribosylation Factor Domain-Containing Protein 1 3 4
  • ADP-Ribosylation Factor Domain Protein 1, 64kDa 2 3
  • Tripartite Motif-Containing Protein 23 3 4
  • Tripartite Motif-Containing 23 2 3
  • GTP-Binding Protein ARD-1 3 4
  • RING Finger Protein 46 3 4
  • ARFD1 3 4
  • RNF46 3 4
  • ARD1 3 4
  • E3 Ubiquitin-Protein Ligase TRIM23 3
  • Tripartite Motif Protein TRIM23 3
  • ARF Domain Protein 1 3
  • EC 6.3.2.- 4

External Ids for TRIM23 Gene

Previous Symbols for TRIM23 Gene

  • ARFD1

Summaries for TRIM23 Gene

Entrez Gene Summary for TRIM23 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM23 Gene

TRIM23 (Tripartite Motif Containing 23) is a Protein Coding gene. Diseases associated with TRIM23 include cholera. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for TRIM23 Gene

  • Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in Lys-63-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.

Gene Wiki entry for TRIM23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM23 Gene

Genomics for TRIM23 Gene

Genomic Location for TRIM23 Gene

Start:
65,589,680 bp from pter
End:
65,625,975 bp from pter
Size:
36,296 bases
Orientation:
Minus strand

Genomic View for TRIM23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM23 Gene

Regulatory Elements for TRIM23 Gene

Proteins for TRIM23 Gene

  • Protein details for TRIM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36406-TRI23_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM23
    Protein Accession:
    P36406
    Secondary Accessions:
    • Q9BZY4
    • Q9BZY5

    Protein attributes for TRIM23 Gene

    Size:
    574 amino acids
    Molecular mass:
    64067 Da
    Quaternary structure:
    • Interacts with PSCD1. Interacts with human cytomegalovirus protein UL144; this interaction might causes auto-ubiquitination of TRAF6, leading to NF-kappaB activation.

    Alternative splice isoforms for TRIM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM23 Gene

Proteomics data for TRIM23 Gene at MOPED

Post-translational modifications for TRIM23 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8

Other Protein References for TRIM23 Gene

No data available for DME Specific Peptides for TRIM23 Gene

Domains for TRIM23 Gene

Gene Families for TRIM23 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI23_HUMAN
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity:
    • P36406
Family:
  • In the C-terminal section; belongs to the small GTPase superfamily. Arf family.:
    • P36406
Similarity:
  • Contains 1 B box-type zinc finger.:
    • P36406
  • Contains 1 RING-type zinc finger.:
    • P36406
genes like me logo Genes that share domains with TRIM23: view

Function for TRIM23 Gene

Molecular function for TRIM23 Gene

UniProtKB/Swiss-Prot Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in Lys-63-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.

Enzyme Numbers (IUBMB) for TRIM23 Gene

Gene Ontology (GO) - Molecular Function for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 8700863
GO:0004842 ubiquitin-protein transferase activity IDA 15684077
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IDA 8700863
genes like me logo Genes that share ontologies with TRIM23: view

miRNA for TRIM23 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM23 Gene

Localization for TRIM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM23 Gene

Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM23 Gene COMPARTMENTS Subcellular localization image for TRIM23 gene
Compartment Confidence
golgi apparatus 5
lysosome 5
vacuole 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 9671726
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane IDA 9671726
genes like me logo Genes that share ontologies with TRIM23: view

Pathways for TRIM23 Gene

SuperPathways for TRIM23 Gene

No Data Available

UniProtKB/Swiss-Prot P36406-TRI23_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with TRIM23: view

No data available for Pathways by source for TRIM23 Gene

Compounds for TRIM23 Gene

(3) Novoseek inferred chemical compound relationships for TRIM23 Gene

Compound -log(P) Hits PubMed IDs
gtp 42.5 4
adp 37.4 2
atp 17.8 2
genes like me logo Genes that share compounds with TRIM23: view

Transcripts for TRIM23 Gene

Unigene Clusters for TRIM23 Gene

Tripartite motif containing 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM23 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TRIM23 Gene

GeneLoc Exon Structure for
TRIM23
ECgene alternative splicing isoforms for
TRIM23

Expression for TRIM23 Gene

mRNA expression in normal human tissues for TRIM23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM23 Gene

SOURCE GeneReport for Unigene cluster for TRIM23 Gene Hs.792

genes like me logo Genes that share expressions with TRIM23: view

Orthologs for TRIM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM23 36
  • 99.65 (n)
  • 100 (a)
TRIM23 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM23 36
  • 91.81 (n)
  • 95.99 (a)
TRIM23 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM23 36
  • 93.79 (n)
  • 97.39 (a)
TRIM23 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim23 36
  • 91.5 (n)
  • 97.81 (a)
Trim23 16
Trim23 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM23 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM23 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim23 36
  • 90.42 (n)
  • 97.21 (a)
chicken
(Gallus gallus)
Aves TRIM23 36
  • 82.93 (n)
  • 94.08 (a)
TRIM23 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM23 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim23 36
  • 78.05 (n)
  • 89.37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5892 36
zebrafish
(Danio rerio)
Actinopterygii trim23 36
  • 76.68 (n)
  • 92.23 (a)
trim23 37
  • 88 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea arc-1 36
  • 49.15 (n)
  • 38.28 (a)
arc-1 37
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToOne
Species with no ortholog for TRIM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM23 Gene

ENSEMBL:
Gene Tree for TRIM23 (if available)
TreeFam:
Gene Tree for TRIM23 (if available)

Paralogs for TRIM23 Gene

Selected SIMAP similar genes for TRIM23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM23: view

Variants for TRIM23 Gene

Sequence variations from dbSNP and Humsavar for TRIM23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10699 -- 65,590,719(-) AAAAG(C/T)TACTC utr-variant-3-prime, intron-variant
rs36133 -- 65,596,688(+) CCTAC(A/G)TGGTG intron-variant
rs36134 -- 65,595,612(+) tccta(A/G)ctact intron-variant
rs36135 -- 65,594,652(+) TACCC(A/C)AAAAA intron-variant
rs36136 -- 65,594,123(+) CTTCT(C/T)TGTCT intron-variant

Relevant External Links for TRIM23 Gene

HapMap Linkage Disequilibrium report
TRIM23

No data available for Structural Variations from Database of Genomic Variants (DGV) for TRIM23 Gene

Disorders for TRIM23 Gene

(1) MalaCards Diseases for TRIM23 Gene

Search for TRIM23 Gene in MalaCards »

(1) Novoseek inferred disease relationships for TRIM23 Gene

Disease -log(P) Hits PubMed IDs
cholera 62.4 1
genes like me logo Genes that share disorders with TRIM23: view

No data available for UniProtKB/Swiss-Prot for TRIM23 Gene

Publications for TRIM23 Gene

  1. Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. (PMID: 9671726) Vitale N. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  2. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PMID: 10748148) Vitale N. … Vaughan M. (J. Biol. Chem. 2000) 3 4 23
  3. ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl- terminal ADP-ribosylation factor domain. (PMID: 8473324) Mishima K. … Vaughan M. (J. Biol. Chem. 1993) 2 3 4
  4. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP- ribosylation factor domain protein 1). (PMID: 15684077) Vichi A. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains. (PMID: 16413270) Vichi A. … Vaughan M. (Meth. Enzymol. 2005) 3 23

Products for TRIM23 Gene

Sources for TRIM23 Gene

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