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Aliases for TRIM23 Gene

Aliases for TRIM23 Gene

  • Tripartite Motif Containing 23 2 3 5
  • ADP-Ribosylation Factor Domain-Containing Protein 1 3 4
  • ADP-Ribosylation Factor Domain Protein 1, 64kDa 2 3
  • Tripartite Motif-Containing Protein 23 3 4
  • Tripartite Motif-Containing 23 2 3
  • GTP-Binding Protein ARD-1 3 4
  • RING Finger Protein 46 3 4
  • ARFD1 3 4
  • RNF46 3 4
  • ARD1 3 4
  • Tripartite Motif Protein TRIM23 3
  • ARF Domain Protein 1 3
  • EC 6.3.2.- 4

External Ids for TRIM23 Gene

Previous HGNC Symbols for TRIM23 Gene

  • ARFD1

Previous GeneCards Identifiers for TRIM23 Gene

  • GC05M064902
  • GC05M064921
  • GC05M064885
  • GC05M061841

Summaries for TRIM23 Gene

Entrez Gene Summary for TRIM23 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM23 Gene

TRIM23 (Tripartite Motif Containing 23) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for TRIM23 Gene

  • Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in Lys-63-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.

Gene Wiki entry for TRIM23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM23 Gene

Genomics for TRIM23 Gene

Regulatory Elements for TRIM23 Gene

Promoters for TRIM23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM23 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM23 Gene

Chromosome:
5
Start:
65,589,680 bp from pter
End:
65,625,975 bp from pter
Size:
36,296 bases
Orientation:
Minus strand

Genomic View for TRIM23 Gene

Genes around TRIM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM23 Gene

Proteins for TRIM23 Gene

  • Protein details for TRIM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36406-TRI23_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM23
    Protein Accession:
    P36406
    Secondary Accessions:
    • Q9BZY4
    • Q9BZY5

    Protein attributes for TRIM23 Gene

    Size:
    574 amino acids
    Molecular mass:
    64067 Da
    Quaternary structure:
    • Interacts with PSCD1. Interacts with human cytomegalovirus protein UL144; this interaction might causes auto-ubiquitination of TRAF6, leading to NF-kappaB activation.

    Alternative splice isoforms for TRIM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM23 Gene

Proteomics data for TRIM23 Gene at MOPED

Post-translational modifications for TRIM23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM23 Gene

Antibody Products

No data available for DME Specific Peptides for TRIM23 Gene

Domains & Families for TRIM23 Gene

Suggested Antigen Peptide Sequences for TRIM23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36406

UniProtKB/Swiss-Prot:

TRI23_HUMAN :
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
  • In the C-terminal section; belongs to the small GTPase superfamily. Arf family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
Family:
  • In the C-terminal section; belongs to the small GTPase superfamily. Arf family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM23: view

Function for TRIM23 Gene

Molecular function for TRIM23 Gene

UniProtKB/Swiss-Prot Function:
Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in Lys-63-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.

Enzyme Numbers (IUBMB) for TRIM23 Gene

Gene Ontology (GO) - Molecular Function for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 15684077
GO:0005525 GTP binding IEA,IDA 8700863
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRIM23: view
genes like me logo Genes that share phenotypes with TRIM23: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM23 Gene

Localization for TRIM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM23 Gene

Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM23 Gene COMPARTMENTS Subcellular localization image for TRIM23 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
nucleus 4
vacuole 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRIM23: view

Pathways & Interactions for TRIM23 Gene

SuperPathways for TRIM23 Gene

No Data Available

UniProtKB/Swiss-Prot P36406-TRI23_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with TRIM23: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM23 Gene

Drugs & Compounds for TRIM23 Gene

(1) Drugs for TRIM23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TRIM23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM23: view

Transcripts for TRIM23 Gene

Unigene Clusters for TRIM23 Gene

Tripartite motif containing 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM23 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TRIM23 Gene

GeneLoc Exon Structure for
TRIM23
ECgene alternative splicing isoforms for
TRIM23

Expression for TRIM23 Gene

mRNA expression in normal human tissues for TRIM23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM23 Gene

This gene is overexpressed in Salivary gland (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM23 Gene



SOURCE GeneReport for Unigene cluster for TRIM23 Gene Hs.792

genes like me logo Genes that share expression patterns with TRIM23: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM23 Gene

Orthologs for TRIM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM23 36
  • 97 (a)
OneToOne
TRIM23 35
  • 99.65 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRIM23 35
  • 91.81 (n)
  • 95.99 (a)
TRIM23 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM23 36
  • 97 (a)
OneToOne
TRIM23 35
  • 93.79 (n)
  • 97.39 (a)
mouse
(Mus musculus)
Mammalia Trim23 16
Trim23 36
  • 97 (a)
OneToOne
Trim23 35
  • 91.5 (n)
  • 97.81 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM23 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM23 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim23 35
  • 90.42 (n)
  • 97.21 (a)
chicken
(Gallus gallus)
Aves TRIM23 35
  • 82.93 (n)
  • 94.08 (a)
TRIM23 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM23 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim23 35
  • 78.05 (n)
  • 89.37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5892 35
zebrafish
(Danio rerio)
Actinopterygii trim23 36
  • 88 (a)
OneToOne
trim23 35
  • 76.68 (n)
  • 92.23 (a)
worm
(Caenorhabditis elegans)
Secernentea arc-1 35
  • 49.15 (n)
  • 38.28 (a)
arc-1 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TRIM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM23 Gene

ENSEMBL:
Gene Tree for TRIM23 (if available)
TreeFam:
Gene Tree for TRIM23 (if available)

Paralogs for TRIM23 Gene

(19) SIMAP similar genes for TRIM23 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM23: view

Variants for TRIM23 Gene

Sequence variations from dbSNP and Humsavar for TRIM23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34046496 - 65,594,628(-) TTGTA(A/G)ATAGC reference, missense
rs40154 -- 65,596,147(+) ATACA(C/T)TCTCT intron-variant
rs40196 -- 65,617,205(+) TCAAA(A/G)ATCAC intron-variant
rs40198 -- 65,611,237(+) AGTCC(A/G)TTTAT intron-variant
rs149393 -- 65,608,323(+) ACAAA(A/T)TAGAG intron-variant

Variation tolerance for TRIM23 Gene

Residual Variation Intolerance Score: 7.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM23 Gene

HapMap Linkage Disequilibrium report
TRIM23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM23 Gene

Disorders for TRIM23 Gene

Relevant External Links for TRIM23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM23

No disorders were found for TRIM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM23 Gene

Publications for TRIM23 Gene

  1. ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl- terminal ADP-ribosylation factor domain. (PMID: 8473324) Mishima K. … Vaughan M. (J. Biol. Chem. 1993) 2 3 4 67
  2. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP- ribosylation factor domain protein 1). (PMID: 15684077) Vichi A. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  3. ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains. (PMID: 16413270) Vichi A. … Vaughan M. (Meth. Enzymol. 2005) 3 23
  4. Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1. (PMID: 10982851) Vitale N. … Vaughan M. (Mol. Cell. Biol. 2000) 3 23
  5. Specific functional interaction of human cytohesin-1 and ADP- ribosylation factor domain protein (ARD1). (PMID: 10748148) Vitale N. … Vaughan M. (J. Biol. Chem. 2000) 3 23

Products for TRIM23 Gene

Sources for TRIM23 Gene

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