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Aliases for JUND Gene

Aliases for JUND Gene

  • Jun D Proto-Oncogene 2 3 5
  • Activator Protein 1 2 3
  • JunD-FL Isoform 2 3
  • Transcription Factor Jun-D 2
  • AP-1 3

External Ids for JUND Gene

Previous GeneCards Identifiers for JUND Gene

  • GC19M018884
  • GC19M018782
  • GC19M018235
  • GC19M018252
  • GC19M018253
  • GC19M018254
  • GC19M018391
  • GC19M017954

Summaries for JUND Gene

Entrez Gene Summary for JUND Gene

  • The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

GeneCards Summary for JUND Gene

JUND (Jun D Proto-Oncogene) is a Protein Coding gene. Diseases associated with JUND include t-cell leukemia and adult t-cell leukemia. Among its related pathways are Integrated Pancreatic Cancer Pathway and EGFR1 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is JUNB.

UniProtKB/Swiss-Prot for JUND Gene

  • Transcription factor binding AP-1 sites.

Gene Wiki entry for JUND Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUND Gene

Genomics for JUND Gene

Regulatory Elements for JUND Gene

Promoters for JUND Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JUND on UCSC Golden Path with GeneCards custom track

Genomic Location for JUND Gene

Chromosome:
19
Start:
18,279,694 bp from pter
End:
18,281,656 bp from pter
Size:
1,963 bases
Orientation:
Minus strand

Genomic View for JUND Gene

Genes around JUND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUND Gene

Proteins for JUND Gene

  • Protein details for JUND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17535-JUND_HUMAN
    Recommended name:
    Transcription factor jun-D
    Protein Accession:
    P17535
    Secondary Accessions:
    • Q53EK9

    Protein attributes for JUND Gene

    Size:
    347 amino acids
    Molecular mass:
    35174 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.
    SequenceCaution:
    • Sequence=CAA40010.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JUND Gene

neXtProt entry for JUND Gene

Proteomics data for JUND Gene at MOPED

Post-translational modifications for JUND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUND Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for JUND (JunD)

No data available for DME Specific Peptides for JUND Gene

Domains & Families for JUND Gene

Suggested Antigen Peptide Sequences for JUND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17535

UniProtKB/Swiss-Prot:

JUND_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Jun subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUND: view

Function for JUND Gene

Molecular function for JUND Gene

GENATLAS Biochemistry:
jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1
UniProtKB/Swiss-Prot Function:
Transcription factor binding AP-1 sites.

Gene Ontology (GO) - Molecular Function for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003713 transcription coactivator activity IBA --
GO:0005515 protein binding IEA,IPI 9989505
GO:0008134 transcription factor binding IEA,IBA --
genes like me logo Genes that share ontologies with JUND: view
genes like me logo Genes that share phenotypes with JUND: view

Animal Models for JUND Gene

MGI Knock Outs for JUND:

Animal Model Products

Transcription Factor Targets for JUND Gene

Selected GeneGlobe predicted Target genes for JUND
Targeted motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
  • Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUND Gene

Localization for JUND Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUND Gene COMPARTMENTS Subcellular localization image for JUND gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for JUND Gene

Pathways & Interactions for JUND Gene

genes like me logo Genes that share pathways with JUND: view

SIGNOR curated interactions for JUND Gene

Is activated by:

Gene Ontology (GO) - Biological Process for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009314 response to radiation IBA --
GO:0009416 response to light stimulus IEA --
GO:0010941 regulation of cell death IBA --
genes like me logo Genes that share ontologies with JUND: view

Drugs & Compounds for JUND Gene

(19) Drugs for JUND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for JUND Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUND: view

Transcripts for JUND Gene

mRNA/cDNA for JUND Gene

Unigene Clusters for JUND Gene

Jun D proto-oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JUND Gene

No ASD Table

Relevant External Links for JUND Gene

GeneLoc Exon Structure for
JUND
ECgene alternative splicing isoforms for
JUND

Expression for JUND Gene

mRNA expression in normal human tissues for JUND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUND Gene

This gene is overexpressed in Blymphocyte (17.6), Placenta (10.2), Peripheral blood mononuclear cells (6.6), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for JUND Gene



SOURCE GeneReport for Unigene cluster for JUND Gene Hs.2780

genes like me logo Genes that share expression patterns with JUND: view

Protein tissue co-expression partners for JUND Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JUND Gene

Orthologs for JUND Gene

This gene was present in the common ancestor of animals.

Orthologs for JUND Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia JUND 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jund 36
  • 81 (a)
OneToOne
Jund 16
Jund 35
  • 80.45 (n)
  • 83.59 (a)
oppossum
(Monodelphis domestica)
Mammalia JUND 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JUND 36
  • 94 (a)
OneToOne
JUND 35
  • 90.63 (n)
  • 92.17 (a)
rat
(Rattus norvegicus)
Mammalia Jund 35
  • 80.65 (n)
  • 83.59 (a)
cow
(Bos Taurus)
Mammalia JUND 35
  • 91.3 (n)
  • 93.62 (a)
lizard
(Anolis carolinensis)
Reptilia JUND 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jund 35
  • 63.87 (n)
  • 70.81 (a)
zebrafish
(Danio rerio)
Actinopterygii jund 36
  • 64 (a)
OneToOne
jund 35
  • 69.95 (n)
  • 67.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jra 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for JUND:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUND Gene

ENSEMBL:
Gene Tree for JUND (if available)
TreeFam:
Gene Tree for JUND (if available)

Paralogs for JUND Gene

Paralogs for JUND Gene

(2) SIMAP similar genes for JUND Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with JUND: view

Variants for JUND Gene

Sequence variations from dbSNP and Humsavar for JUND Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_055247 -
rs9413 -- 18,280,055(-) TTTTT(C/T)TCTTT utr-variant-3-prime
rs15212 -- 18,279,854(-) TTTTT(G/T)TTCTG utr-variant-3-prime
rs3075299 -- 18,280,067(+) AAAAA(-/AA)GTAAA utr-variant-3-prime
rs4393694 -- 18,280,054(+) CAAAG(A/G)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JUND Gene

Variant ID Type Subtype PubMed ID
dgv3774n71 CNV Loss 21882294
dgv3779n71 CNV Loss 21882294
dgv3780n71 CNV Loss 21882294
nsv911271 CNV Loss 21882294
nsv828472 CNV Loss 20364138
dgv3781n71 CNV Loss 21882294
esv29755 CNV Loss 19812545

Variation tolerance for JUND Gene

Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JUND Gene

HapMap Linkage Disequilibrium report
JUND

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene

Disorders for JUND Gene

MalaCards: The human disease database

(3) MalaCards diseases for JUND Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
multiple endocrine neoplasia 1
  • multiple endocrine neoplasia type 1
- elite association - COSMIC cancer census association via MalaCards
Search JUND in MalaCards View complete list of genes associated with diseases

Relevant External Links for JUND

Genetic Association Database (GAD)
JUND
Human Genome Epidemiology (HuGE) Navigator
JUND
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JUND
genes like me logo Genes that share disorders with JUND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUND Gene

Publications for JUND Gene

  1. Structure and function of human jun-D. (PMID: 1903194) Berger I. … Shaul Y. (Oncogene 1991) 2 3 4 23 67
  2. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A. … Uhal B.D. (FASEB J. 2009) 3 23
  3. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PMID: 18071306) Nakayama T. … Yoshie O. (Oncogene 2008) 3 23
  4. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PMID: 18386285) Mehraein-Ghomi F. … Wilding G. (Prostate 2008) 3 23
  5. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. (PMID: 17204476) Hock T.D. … Agarwal A. (J. Biol. Chem. 2007) 3 23

Products for JUND Gene

Sources for JUND Gene

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