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Aliases for JUNB Gene

Aliases for JUNB Gene

  • Jun B Proto-Oncogene 2 3
  • Transcription Factor Jun-B 3
  • Activator Protein 1 3
  • AP-1 3

External Ids for JUNB Gene

Summaries for JUNB Gene

GeneCards Summary for JUNB Gene

JUNB (Jun B Proto-Oncogene) is a Protein Coding gene. Diseases associated with JUNB include fumarate hydratase deficiency and breast cancer. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot for JUNB Gene

  • Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3

Gene Wiki entry for JUNB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUNB Gene

Genomics for JUNB Gene

Genomic Location for JUNB Gene

Start:
12,791,496 bp from pter
End:
12,793,315 bp from pter
Size:
1,820 bases
Orientation:
Plus strand

Genomic View for JUNB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JUNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUNB Gene

Regulatory Elements for JUNB Gene

Proteins for JUNB Gene

  • Protein details for JUNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17275-JUNB_HUMAN
    Recommended name:
    Transcription factor jun-B
    Protein Accession:
    P17275
    Secondary Accessions:
    • Q96GH3

    Protein attributes for JUNB Gene

    Size:
    347 amino acids
    Molecular mass:
    35879 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

neXtProt entry for JUNB Gene

Proteomics data for JUNB Gene at MOPED

Post-translational modifications for JUNB Gene

Other Protein References for JUNB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for JUNB Gene

Domains for JUNB Gene

Gene Families for JUNB Gene

HGNC:
  • bZIP :basic leucine zipper proteins

UniProtKB/Swiss-Prot:

JUNB_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • P17275
Family:
  • Belongs to the bZIP family. Jun subfamily.:
    • P17275
genes like me logo Genes that share domains with JUNB: view

Function for JUNB Gene

Molecular function for JUNB Gene

GENATLAS Biochemistry: jun protooncogene homolog B,ligand induced,immediate (primary) early response gene
UniProtKB/Swiss-Prot Function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3
UniProtKB/Swiss-Prot Induction: By growth factors

Gene Ontology (GO) - Molecular Function for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding TAS 10764760
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with JUNB: view
genes like me logo Genes that share phenotypes with JUNB: view

Transcription Factor Targeting for JUNB Gene

Selected GeneGlobe predicted Target genes for JUNB

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for JUNB Gene

Localization for JUNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUNB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUNB Gene COMPARTMENTS Subcellular localization image for JUNB gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 2513129
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with JUNB: view

Pathways for JUNB Gene

SuperPathways for JUNB Gene

genes like me logo Genes that share pathways with JUNB: view

Gene Ontology (GO) - Biological Process for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with JUNB: view

Compounds for JUNB Gene

(57) Novoseek inferred chemical compound relationships for JUNB Gene

Compound -log(P) Hits PubMed IDs
sch 39166 68.7 2
12-o-tetradecanoylphorbol 13-acetate 68.2 19
phorbol 56.2 4
okadaic acid 51 9
leucine 41.7 5
genes like me logo Genes that share compounds with JUNB: view

Transcripts for JUNB Gene

mRNA/cDNA for JUNB Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(667) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUNB Gene

Jun B proto-oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JUNB Gene

No ASD Table

Relevant External Links for JUNB Gene

GeneLoc Exon Structure for
JUNB
ECgene alternative splicing isoforms for
JUNB

Expression for JUNB Gene

mRNA expression in normal human tissues for JUNB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JUNB Gene

This gene is overexpressed in Fallopian Tube (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JUNB Gene

SOURCE GeneReport for Unigene cluster for JUNB Gene Hs.25292

genes like me logo Genes that share expressions with JUNB: view

Orthologs for JUNB Gene

This gene was present in the common ancestor of animals.

Orthologs for JUNB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JUNB 36
  • 99.9 (n)
  • 99.71 (a)
JUNB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JUNB 36
  • 92.7 (n)
  • 96.54 (a)
JUNB 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JUNB 36
  • 92.89 (n)
  • 97.12 (a)
JUNB 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Junb 36
  • 88.95 (n)
  • 93.6 (a)
Junb 16
Junb 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JUNB 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Junb 36
  • 88.47 (n)
  • 93.9 (a)
lizard
(Anolis carolinensis)
Reptilia JUNB 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia junb 36
  • 60 (n)
  • 59.66 (a)
zebrafish
(Danio rerio)
Actinopterygii junba 37
  • 58 (a)
OneToMany
junbb 37
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Jra 37
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for JUNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUNB Gene

ENSEMBL:
Gene Tree for JUNB (if available)
TreeFam:
Gene Tree for JUNB (if available)

Paralogs for JUNB Gene

Paralogs for JUNB Gene

Selected SIMAP similar genes for JUNB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JUNB: view

Variants for JUNB Gene

Sequence variations from dbSNP and Humsavar for JUNB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1061500 -- 12,793,119(+) GCCCC(C/G)CCGCC utr-variant-3-prime
rs1061595 -- 12,793,184(+) CCTCT(C/T)TGCAC utr-variant-3-prime
rs1061605 -- 12,793,188(+) TCTGC(A/C)CCGTA utr-variant-3-prime
rs2229510 -- 12,792,245(+) GTGTC(A/C)CTGGG synonymous-codon, reference
rs2599483 -- 12,790,248(+) ATGCG(A/G)CGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for JUNB Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294
nsv911079 CNV Loss 21882294
dgv3734n71 CNV Loss 21882294

Relevant External Links for JUNB Gene

HapMap Linkage Disequilibrium report
JUNB

Disorders for JUNB Gene

(39) Novoseek inferred disease relationships for JUNB Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 51.3 2
myeloid leukemia 48.9 7
anaplastic large cell lymphoma 44.9 8
hodgkin disease 33.3 10
myeloproliferative disorders 29 4

Relevant External Links for JUNB

Genetic Association Database (GAD)
JUNB
Human Genome Epidemiology (HuGE) Navigator
JUNB
genes like me logo Genes that share disorders with JUNB: view

No data available for UniProtKB/Swiss-Prot for JUNB Gene

Publications for JUNB Gene

  1. jun-B inhibits and c-fos stimulates the transforming and trans- activating activities of c-jun. (PMID: 2513129) Schuette J. … Minna J. (Cell 1989) 2 3 4
  2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PMID: 2112242) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1990) 3 4
  3. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. (PMID: 20132737) Son Y.O. … Lee J.C. (BMB Rep 2010) 3 23
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 49
  5. Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. (PMID: 8530030) Phinney D.G. … Ryder K. (Genomics 1995) 3 4

Products for JUNB Gene

  • Addgene plasmids for JUNB

Sources for JUNB Gene

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