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Aliases for JAK1 Gene

Aliases for JAK1 Gene

  • Janus Kinase 1 2 3 4
  • EC 2.7.10.2 4 64
  • JAK1B 3 4
  • JAK1A 3 4
  • Tyrosine-Protein Kinase JAK1 3
  • EC 2.7.10 64
  • JAK-1 4
  • JTK3 3

External Ids for JAK1 Gene

Previous Symbols for JAK1 Gene

  • JAK1B

Summaries for JAK1 Gene

Entrez Gene Summary for JAK1 Gene

  • Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]

GeneCards Summary for JAK1 Gene

JAK1 (Janus Kinase 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein tyrosine kinase activity and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for JAK1 Gene

  • Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Gene Wiki entry for JAK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAK1 Gene

Genomics for JAK1 Gene

Genomic Location for JAK1 Gene

Start:
64,833,223 bp from pter
End:
64,966,910 bp from pter
Size:
133,688 bases
Orientation:
Minus strand

Genomic View for JAK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAK1 Gene

Regulatory Elements for JAK1 Gene

Proteins for JAK1 Gene

  • Protein details for JAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23458-JAK1_HUMAN
    Recommended name:
    Tyrosine-protein kinase JAK1
    Protein Accession:
    P23458
    Secondary Accessions:
    • Q59GQ2
    • Q9UD26

    Protein attributes for JAK1 Gene

    Size:
    1154 amino acids
    Molecular mass:
    133277 Da
    Quaternary structure:
    • Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.
    SequenceCaution:
    • Sequence=AAA36527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA36527.1; Type=Frameshift; Positions=858, 862; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JAK1 Gene

neXtProt entry for JAK1 Gene

Proteomics data for JAK1 Gene at MOPED

Post-translational modifications for JAK1 Gene

  • Phosphorylated. Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys213, Lys227, Lys245, Lys249, and Lys269

Other Protein References for JAK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for JAK1 Gene

Gene Families for JAK1 Gene

UniProtKB/Swiss-Prot:

JAK1_HUMAN
Domain:
  • Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.:
    • P23458
  • The FERM domain mediates interaction with JAKMIP1:
    • P23458
  • Contains 1 FERM domain.:
    • P23458
  • Contains 2 protein kinase domains.:
    • P23458
  • Contains 1 SH2 domain.:
    • P23458
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.:
    • P23458
genes like me logo Genes that share domains with JAK1: view

Function for JAK1 Gene

Molecular function for JAK1 Gene

GENATLAS Biochemistry: Janus tyrosine kinase 1A,non receptor type,class III,murine FD-22 homolog,widely expressed,involved in signal transduction of several hematopoietic cytokine receptors,mediating the activation of STAT proteins
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Enzyme Numbers (IUBMB) for JAK1 Gene

Gene Ontology (GO) - Molecular Function for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005131 growth hormone receptor binding ISS 10502458
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with JAK1: view
genes like me logo Genes that share phenotypes with JAK1: view

Animal Models for JAK1 Gene

MGI Knock Outs for JAK1:

No data available for Transcription Factor Targeting and HOMER Transcription for JAK1 Gene

Localization for JAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAK1 Gene

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JAK1 Gene COMPARTMENTS Subcellular localization image for JAK1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10502458
GO:0005737 cytoplasm IDA 10502458
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with JAK1: view

Pathways for JAK1 Gene

genes like me logo Genes that share pathways with JAK1: view

Gene Ontology (GO) - Biological Process for JAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 1848670
GO:0007167 enzyme linked receptor protein signaling pathway --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0016477 cell migration IBA --
GO:0018108 peptidyl-tyrosine phosphorylation --
genes like me logo Genes that share ontologies with JAK1: view

Compounds for JAK1 Gene

(36) ApexBio Compounds for JAK1 Gene

Compound Action Cas Number
1,2,3,4,5,6-Hexabromocyclohexane Potently and directly inhibits JAK2. [1837-91-8]
AZ 960 novel inhibitor of JAKs [905586-69-8]
AZD1480 novel small-molecule JAK inhibitor [935666-88-9]
Baricitinib (LY3009104, INCB028050) new selective orally bioavailable inhibitor of JAK1 or JAK2. [1187594-09-7]
Baricitinib phosphate selective orally bioavailable JAK1/JAK2 inhibitor [1187595-84-1]
BMS-911543 potent and selective inhibitor of JAK2. [1271022-90-2]
CEP-33779 highly selective, orally active inhibitor of JAK2 [1257704-57-6]
Cercosporamide Potent inhibitor of Mnk2 and JAK3. [131436-22-1]
Cucurbitacin I Selective inhibitor of STAT3/JAK2. [2222-7-3]
CYT387 potent and selective inhibitor of JAK1, JAK2,TYK2 [1056634-68-4]
CYT387 sulfate salt ATP-competitive small molecule JAK1/JAK2 inhibitor. [1056636-06-6]
JAK2 Inhibitor V, Z3 novel specific inhibitor of Jak2 tyrosine kinase. [195371-52-9]
JANEX-1 rationally designed novel JAK3 inhibitor. [202475-60-3]
Lestaurtinib Potent JAK2, FLT3 and TrkA inhibitor. [111358-88-4]
LY2784544 potent JAK2 inhibitor [1229236-86-5]
NSC 33994 Selective inhibitor of JAK2. [82058-16-0]
NVP-BSK805 potent inhibitior of JAK2(V617F) and JAK2 wild-type enzymes. [1092499-93-8]
NVP-BSK805 2HCl potent and selective ATP-competitive JAK2 inhibitor [1092499-93-8]
Pyridone 6 pan-JAK inhibitor [457081-03-7]
Ruxolitinib (INCB018424) specific inhibitor of JAK1 and JAK2 [941678-49-5]
Ruxolitinib phosphate orally bioavailable JAK inhibitor [1092939-17-7]
Ruxolitinib sulfate orally bioavailable JAK inhibitor [1092939-16-6]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SD 1008 JAK2/STAT3 signaling pathway inhibitor. [960201-81-4]
S-Ruxolitinib (INCB018424) potent and selective small-molecule JAK1 and JAK2 inhibitor. [941685-37-6]
TCS 21311 Potent JAK3 inhibitor. [1260181-14-3]
TG101209 JAK2 and 3 inhibitor, also inhibits Flt3 and RET [936091-14-4]
TG101348 (SAR302503) potent and selective inhibitor of JAK2. [936091-26-8]
Tofacitinib (CP-690550) Citrate potent inhibitor of JAK3 [540737-29-9]
Tofacitinib (CP-690550,Tasocitinib) novel oral JAK inhibitor. [477600-75-2]
WHI-P154 potent JAK3 inhibitor [211555-04-3]
WHI-P97 rationally designed potent inhibitor of JAK3. [211555-05-4]
WP1066 Cell permeable STAT3 inhibitor [857064-38-1]
XL019 potent and selective JAK2 inhibitor [945755-56-6]
ZM 39923 HCl JAK1/3 inhibitor [1021868-92-7]
ZM 449829 Potent, selective inhibitor of JAK3 [4452-6-6]

(2) HMDB Compounds for JAK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(30) Novoseek inferred chemical compound relationships for JAK1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 84.9 156
gp 130 81.8 34
ifn-alpha 59.9 8
piceatannol 58.7 3
vanadate 50.5 3
genes like me logo Genes that share compounds with JAK1: view

Transcripts for JAK1 Gene

Unigene Clusters for JAK1 Gene

Janus kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JAK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1: - - - -
SP2:
SP3: - - -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for JAK1 Gene

GeneLoc Exon Structure for
JAK1
ECgene alternative splicing isoforms for
JAK1

Expression for JAK1 Gene

mRNA expression in normal human tissues for JAK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JAK1 Gene

SOURCE GeneReport for Unigene cluster for JAK1 Gene Hs.207538

mRNA Expression by UniProt/SwissProt for JAK1 Gene

P23458-JAK1_HUMAN
Tissue specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
genes like me logo Genes that share expressions with JAK1: view

Orthologs for JAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for JAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAK1 36
  • 99.68 (n)
  • 99.91 (a)
JAK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JAK1 36
  • 91.85 (n)
  • 97.22 (a)
JAK1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAK1 36
  • 92.37 (n)
  • 98.01 (a)
JAK1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jak1 36
  • 89.5 (n)
  • 95.05 (a)
Jak1 16
Jak1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia JAK1 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jak1 36
  • 89.44 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves JAK1 36
  • 75.49 (n)
  • 81.79 (a)
JAK1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 78 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia jak1 36
  • 71.83 (n)
  • 77.73 (a)
Str.19081 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9095 36
zebrafish
(Danio rerio)
Actinopterygii jak1 36
  • 64.52 (n)
  • 63.6 (a)
jak1 37
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T14E8.1a 38
  • 32 (a)
T14E8.1b 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for JAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JAK1 Gene

ENSEMBL:
Gene Tree for JAK1 (if available)
TreeFam:
Gene Tree for JAK1 (if available)

Paralogs for JAK1 Gene

Paralogs for JAK1 Gene

Selected SIMAP similar genes for JAK1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with JAK1: view

Variants for JAK1 Gene

Sequence variations from dbSNP and Humsavar for JAK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs167454 -- 64,837,418(-) CAGCC(A/G)GGAAC intron-variant
rs172659 -- 64,928,960(+) CCTCA(A/G)AATAA intron-variant
rs182574 -- 64,916,770(+) aggca(A/G)aggtt intron-variant
rs184305 -- 64,926,268(+) CACTA(A/G)ATCTT intron-variant
rs186334 -- 64,927,290(+) gccta(A/G)aattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAK1 Gene

Variant ID Type Subtype PubMed ID
nsv525227 CNV Loss 19592680
nsv823098 CNV Loss 20364138
nsv830059 CNV Loss 17160897
esv2671749 CNV Deletion 23128226
esv275588 CNV Loss 21479260
esv2421783 CNV Deletion 20811451

Relevant External Links for JAK1 Gene

HapMap Linkage Disequilibrium report
JAK1

Disorders for JAK1 Gene

(4) University of Copenhagen DISEASES for JAK1 Gene

(26) Novoseek inferred disease relationships for JAK1 Gene

Disease -log(P) Hits PubMed IDs
polycythemia vera 51.1 1
fibrosarcoma 49.1 11
leukemia 46.4 3
severe combined immunodeficiency, x-linked 44 1
myeloma 19.5 3

Relevant External Links for JAK1

Genetic Association Database (GAD)
JAK1
Human Genome Epidemiology (HuGE) Navigator
JAK1
genes like me logo Genes that share disorders with JAK1: view

No data available for UniProtKB/Swiss-Prot for JAK1 Gene

Publications for JAK1 Gene

  1. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. (PMID: 1848670) Wilks A.F. … Ziemiecki A. (Mol. Cell. Biol. 1991) 2 3 4 23
  2. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. (PMID: 18362173) Flex E. … Tartaglia M. (J. Exp. Med. 2008) 3 23 49
  3. Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. (PMID: 18320073) Xiong H. … Fang J.Y. (Neoplasia 2008) 3 23
  4. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. (PMID: 18413761) Ahmad R. … Kufe D. (Cancer Res. 2008) 3 23
  5. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. (PMID: 18559588) Jeong E.G. … Lee S.H. (Clin. Cancer Res. 2008) 3 23

Products for JAK1 Gene

  • Addgene plasmids for JAK1

Sources for JAK1 Gene

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