Aliases for IVL Gene
External Ids for IVL Gene
- HGNC: 6187
- Entrez Gene: 3713
- Ensembl: ENSG00000163207
- OMIM: 147360
- UniProtKB: P07476
Previous GeneCards Identifiers for IVL Gene
- GC01P150697
- GC01P148663
- GC01P149656
- GC01P150097
- GC01P149695
- GC01P151147
- GC01P124244
Summaries for IVL Gene
-
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
GeneCards Summary for IVL Gene
IVL (Involucrin) is a Protein Coding gene. Diseases associated with IVL include Darier Disease and Bullous Pemphigoid. Among its related pathways are Corticotropin-releasing hormone and G-Beta Gamma Signaling. GO annotations related to this gene include structural molecule activity and protein binding, bridging.
UniProtKB/Swiss-Prot for IVL Gene
-
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IVL Gene
Genomics for IVL Gene
Regulatory Elements for IVL Gene
Enhancers for IVL Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around IVL on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the IVL gene promoter:
Regulatory Element Products
Genomic Location for IVL Gene
- Chromosome:
- 1
- Start:
- 152,908,545 bp from pter
- End:
- 152,911,886 bp from pter
- Size:
- 3,342 bases
- Orientation:
- Plus strand
Genomic View for IVL Gene
Genes around IVL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21 by Entrez Gene
- 1q21 by HGNC
IVL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IVL Gene
Proteins for IVL Gene
-
Protein details for IVL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07476-INVO_HUMAN
- Recommended name:
- Involucrin
- Protein Accession:
- P07476
- Q5T7P4
Protein attributes for IVL Gene
- Size:
- 585 amino acids
- Molecular mass:
- 68479 Da
- Quaternary structure:
-
- Directly or indirectly cross-linked to cornifelin (CNFN).
Protein Expression for IVL Gene
Post-translational modifications for IVL Gene
- Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IVL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IVL
-
Cloud-Clone Corp. Antibodies for IVL
- Invitrogen Antibodies for IVL
- antibodies-online Antibodies for IVL: See all 129
- GeneTex IVL antibody for IVL
-
Santa Cruz Biotechnology (SCBT) Antibodies for IVL
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IVL
- Origene Custom Protein Services for IVL
- Novus Biologicals proteins for IVL
- ProSpec Recombinant Proteins for IVL
-
Cloud-Clone Corp. Proteins for IVL
- antibodies-online Proteins for IVL: See all 24
- Search antibodies-online for peptides
- Search GeneTex for Proteins for IVL
No data available for DME Specific Peptides for IVL Gene
Domains & Families for IVL Gene
Protein Domains for IVL Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IVL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07476- Family:
-
- Belongs to the involucrin family.
No data available for Gene Families for IVL Gene
Function for IVL Gene
Molecular function for IVL Gene
- GENATLAS Biochemistry:
- involucrin,precursor of cornified cell enveloppe (major component of keratinocyte cross-linked enveloppe),SPRR family,cytosol protein ultimately cross-linked to membrane by transglutaminase
- UniProtKB/Swiss-Prot Function:
- Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IDA | 42494 |
| GO:0005515 | protein binding | IPI | 21044950 |
Phenotypes for IVL Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for IVL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IVL gene
- Search ViGene Biosciences for IVL
CRISPR Products
-
OriGene CRISPR knockouts for IVL
-
Santa Cruz Biotechnology (SCBT) CRISPR for IVL
- GenScript: Design CRISPR guide RNA sequences for IVL
miRNA for IVL Gene
- miRTarBase miRNAs that target IVL
miRNA Products
- Search ViGene Biosciences for IVL
Clone Products
- OriGene ORF clones in rat for IVL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for IVL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IVL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IVL gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IVL Gene
Localization for IVL Gene
Subcellular locations from UniProtKB/Swiss-Prot for IVL Gene
- Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 42494 |
Pathways & Interactions for IVL Gene
More details on SuperPathways for IVLPathways by source for IVL Gene
2 BioSystems pathways for IVL Gene
1 Qiagen pathway for IVL Gene
Interacting Proteins for IVL Gene
Selected Interacting proteins:
ENSP00000357753
P07476-INVO_HUMAN
for IVL Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0018149 | peptide cross-linking | IDA | 10908733 |
| GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine | TAS | 1601889 |
No data available for SIGNOR curated interactions for IVL Gene
Transcripts for IVL Gene
mRNA/cDNA for IVL Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for IVL
-
Santa Cruz Biotechnology (SCBT) CRISPR for IVL
- GenScript: Design CRISPR guide RNA sequences for IVL
miRNA Products
- Search ViGene Biosciences for IVL
Clone Products
- OriGene ORF clones in rat for IVL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for IVL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Corneal Transient Amplifying Cells Corneal Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
- Limbal Superbasal Epithelial Cells Limbus Epithelium
- Esophageal keratinocytes
- Epidermis (Integumentary System)
-
Eye (Sensory Organs)
- Corneal Transient Amplifying Cells Corneal Epithelium
- Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
- Adult Corneal Basal Epithelial Cells Corneal Epithelium
- Limbal Superbasal Epithelial Cells Limbus Epithelium
- NULL (Integumentary System)
- Hair
- Esophagus
- Uncategorized
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for IVL Gene
This gene is overexpressed in Esophagus - Mucosa (x13.5), Vagina (x9.9), Cervix - Ectocervix (x8.8), Minor Salivary Gland (x7.7), Skin - Not Sun Exposed (Suprapubic) (x6.9), and Skin - Sun Exposed (Lower leg) (x5.1).
This gene is overexpressed in Cervix (28.1), Esophagus (9.8), Oral epithelium (9.3), and Saliva (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IVL Gene
SOURCE GeneReport for Unigene cluster for IVL Gene Hs.516439
mRNA Expression by UniProt/SwissProt for IVL Gene
P07476-INVO_HUMAN
Tissue specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for IVL
Orthologs for IVL Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IVL 35 |
|
||
| IVL 36 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | IVL 36 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IVL 36 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ivl 36 |
|
OneToOne |
- Species with no ortholog for IVL:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IVL Gene
No data available for Paralogs for IVL Gene
Variants for IVL Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2229496 | - | 152,910,134(+) | AGAAA(A/G)CACAA | reference, missense | |
| rs11205133 | - | 152,910,294(+) | gcacc(C/T)agagc | reference, missense | |
| rs12035307 | - | 152,910,317(+) | agctg(A/G)agcac | reference, missense | |
| rs7520711 | - | 152,910,506(+) | tccca(C/G)agcag | reference, missense | |
| rs11205137 | - | 152,910,731(+) | tgggg(A/C)agctg | reference, missense |
Gene Damage Index Score:
4.14;
61.43% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IVL Gene
Disorders for IVL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| darier disease |
|
|
| bullous pemphigoid |
|
|
| porokeratosis |
|
|
| keratosis palmoplantaris striata |
|
|
| mixed endometrial stromal and smooth muscle tumor |
|
|
Search IVL in MalaCards
View complete list of genes associated with diseases
Relevant External Links for IVL
No data available for UniProtKB/Swiss-Prot and Genatlas for IVL Gene
Publications for IVL Gene
- Structure and evolution of the human involucrin gene. (PMID: 2873896) Eckert R.L. … Green H. (Cell 1986) 2 3 4 67
- Comparison between human fetal and adult skin. (PMID: 19701759) Coolen N.A. … Ulrich M.M. (Arch. Dermatol. Res. 2010) 3 23
- Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions. (PMID: 19515043) Barcelos A.C. … Sotto M.N. (J. Cutan. Pathol. 2009) 3 23
- Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311. (PMID: 17943181) Zhu L. … Eckert R.L. (J. Invest. Dermatol. 2008) 3 23
- PPAR gamma is an important transcription factor in 1 alpha,25-dihydroxyvitamin D3-induced involucrin expression. (PMID: 18077140) Dai X. … Hashimoto K. (J. Dermatol. Sci. 2008) 3 23
Products for IVL Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IVL
- Origene Custom Protein Services for IVL
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for IVL
- Browse OriGene Inhibitory RNA Products For IVL
- OriGene qPCR primer pairs for IVL
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
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- GenScript: Design CRISPR guide RNA sequences for IVL
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- Novus Biologicals Antibodies for IVL
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- Cloud-Clone Corp. Antibodies for IVL
- Cloud-Clone Corp. Proteins for IVL
- Cloud-Clone Corp Assay Kits for IVL
- antibodies-online Antibodies for IVL: See all 129
- antibodies-online Kits for IVL: See all 29
- antibodies-online Proteins for IVL: See all 24
- Search antibodies-online for peptides
- GeneTex IVL antibody for IVL
- Search GeneTex for Proteins for IVL
- ViGene Biosciences adenoviral particle packaged cDNA for IVL gene
- ViGene Biosciences lentiviral particle packaged cDNA for IVL gene
- ViGene Biosciences lentiviral particle packaged cDNA for IVL gene
- ViGene Biosciences ready-to-package AAV shRNAs for IVL gene
- ViGene Biosciences ready-to-package AAV shRNAs for IVL gene
- ViGene Biosciences ready-to-package AAV shRNAs for IVL gene
- Search ViGene Biosciences for IVL
- Search ViGene Biosciences for IVL
- Santa Cruz Biotechnology (SCBT) Antibodies for IVL
- Search Santa Cruz Biotechnology (SCBT) for IVL siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IVL
Sources for IVL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
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- (105) BioGPS
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- (107) COMPARTMENTS
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- (109) PaxDb
- (110) ApexBio
- (111) Addgene
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- (113) antibodies-online
- (114) CYP
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- (116) SwitchGear Genomics
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- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (149) ENCODE
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