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Aliases for ITPR2 Gene

Aliases for ITPR2 Gene

  • Inositol 1,4,5-Trisphosphate Receptor, Type 2 2 3
  • Inositol 1,4,5-Triphosphate Receptor, Type 2 2 3
  • Type 2 Inositol 1,4,5-Trisphosphate Receptor 3 4
  • Cilia And Flagella Associated Protein 48 2 3
  • Type 2 InsP3 Receptor 3 4
  • InsP3R2 3 4
  • IP3R 2 3 4
  • Inositol 1,4,5-Trisphosphate Receptor Type 2 3
  • IP3 Receptor Isoform 2 4
  • IP3 Receptor 3
  • CFAP48 3
  • IP3R2 3
  • ANHD 3

External Ids for ITPR2 Gene

Previous GeneCards Identifiers for ITPR2 Gene

  • GC12M026850
  • GC12M026502
  • GC12M026390
  • GC12M026381
  • GC12M026377
  • GC12M026258

Summaries for ITPR2 Gene

GeneCards Summary for ITPR2 Gene

ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include phosphatidylinositol binding and calcium ion transmembrane transporter activity. An important paralog of this gene is RYR1.

UniProtKB/Swiss-Prot for ITPR2 Gene

  • Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).

Tocris Summary for ITPR2 Gene

  • Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Gene Wiki entry for ITPR2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPR2 Gene

Genomics for ITPR2 Gene

Regulatory Elements for ITPR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPR2 Gene

26,335,352 bp from pter
26,833,198 bp from pter
497,847 bases
Minus strand

Genomic View for ITPR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPR2 Gene

Proteins for ITPR2 Gene

  • Protein details for ITPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 2
    Protein Accession:
    Secondary Accessions:
    • O94773

    Protein attributes for ITPR2 Gene

    2701 amino acids
    Molecular mass:
    308064 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interacts with CABP1.
    • Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor

    Alternative splice isoforms for ITPR2 Gene


neXtProt entry for ITPR2 Gene

Proteomics data for ITPR2 Gene at MOPED

Post-translational modifications for ITPR2 Gene

  • Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
  • Ubiquitination at Lys909 and Lys1589
  • Modification sites at PhosphoSitePlus

Other Protein References for ITPR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITPR2 Gene

Domains for ITPR2 Gene

Gene Families for ITPR2 Gene

  • ITPR :Ion channels / Inositol triphosphate receptors

Suggested Antigen Peptide Sequences for ITPR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14571
  • The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region
  • Contains 5 MIR domains.
  • Belongs to the InsP3 receptor family.
genes like me logo Genes that share domains with ITPR2: view

Function for ITPR2 Gene

Molecular function for ITPR2 Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate receptor,type 2,coexpressed with RYR3 in neurons and smooth muscle cells forming heterotetrameric channel with ITPR1 and ITPR3,involved in mobilization from the endoplastic reticulum,highly sensitive to IP3,required for long lasting,regular Ca++ oscillations,transcriptionally regulated during myelopoiesis target of EVI-1 and EVI1-VP16 fusion gene
UniProtKB/Swiss-Prot Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).

Gene Ontology (GO) - Molecular Function for ITPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA --
GO:0005262 calcium channel activity --
GO:0005488 binding --
GO:0015085 calcium ion transmembrane transporter activity TAS 8081734
genes like me logo Genes that share ontologies with ITPR2: view
genes like me logo Genes that share phenotypes with ITPR2: view

Animal Models for ITPR2 Gene

MGI Knock Outs for ITPR2:

Animal Model Products

miRNA for ITPR2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITPR2 Gene

Localization for ITPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPR2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ITPR2 Gene COMPARTMENTS Subcellular localization image for ITPR2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ITPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 10828023
GO:0005938 cell cortex IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ITPR2: view

Pathways for ITPR2 Gene

SuperPathways for ITPR2 Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Ca-dependent events
3 Development Angiotensin activation of ERK
4 fMLP Pathway
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with ITPR2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 19120137
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006810 transport TAS 8081734
GO:0006811 ion transport --
genes like me logo Genes that share ontologies with ITPR2: view

Compounds for ITPR2 Gene

(2) Tocris Compounds for ITPR2 Gene

Compound Action Cas Number
(-)-Xestospongin C Inhibits IP3-mediated Ca2+ release [88903-69-9]
2-APB IP3 receptor antagonist. Also TRP channel modulator [524-95-8]

(2) HMDB Compounds for ITPR2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate

(6) IUPHAR Ligand for ITPR2 Gene

Ligand Type Action Affinity Pubmed IDs
IP3 Activator None
decavanadate Activator None
Ca2+ Antagonist Antagonist
Ins(2,4,5)P3 Activator None
heparin Antagonist Antagonist
adenophostin A Activator None

(3) Novoseek inferred chemical compound relationships for ITPR2 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4,5 trisphosphate 82.5 14
ryanodine 60.4 3
calcium 49.4 15
genes like me logo Genes that share compounds with ITPR2: view

Transcripts for ITPR2 Gene

Unigene Clusters for ITPR2 Gene

Inositol 1,4,5-trisphosphate receptor, type 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPR2 Gene

No ASD Table

Relevant External Links for ITPR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITPR2 Gene

mRNA expression in normal human tissues for ITPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ITPR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.2) and Rectum (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPR2 Gene

SOURCE GeneReport for Unigene cluster for ITPR2 Gene Hs.512235

mRNA Expression by UniProt/SwissProt for ITPR2 Gene

Tissue specificity: Isoform Short is found in skeletal muscle and heart
genes like me logo Genes that share expressions with ITPR2: view

Expression partners for ITPR2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ITPR2 Gene

Orthologs for ITPR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITPR2 35
  • 91.81 (n)
  • 97.26 (a)
ITPR2 36
  • 96 (a)
(Canis familiaris)
Mammalia ITPR2 35
  • 93.34 (n)
  • 97.89 (a)
ITPR2 36
  • 98 (a)
(Mus musculus)
Mammalia Itpr2 35
  • 85.09 (n)
  • 95.82 (a)
Itpr2 16
Itpr2 36
  • 96 (a)
(Pan troglodytes)
Mammalia ITPR2 35
  • 99.1 (n)
  • 99.25 (a)
ITPR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Itpr2 35
  • 84.77 (n)
  • 95.34 (a)
(Monodelphis domestica)
Mammalia ITPR2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 88 (a)
-- 36
  • 94 (a)
-- 36
  • 84 (a)
(Gallus gallus)
Aves ITPR2 35
  • 83.05 (n)
  • 92.99 (a)
ITPR2 36
  • 93 (a)
(Anolis carolinensis)
Reptilia ITPR2 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itpr2 35
  • 75.24 (n)
  • 88.5 (a)
(Danio rerio)
Actinopterygii itpr2 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Itp-r83A 37
  • 54 (a)
Itp-r83A 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea itr-1 37
  • 36 (a)
itr-1 36
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2722 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for ITPR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITPR2 Gene

Gene Tree for ITPR2 (if available)
Gene Tree for ITPR2 (if available)

Paralogs for ITPR2 Gene

Paralogs for ITPR2 Gene

Selected SIMAP similar genes for ITPR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITPR2: view

Variants for ITPR2 Gene

Sequence variations from dbSNP and Humsavar for ITPR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2570 -- 26,338,905(-) GAGAG(C/T)TGAAA utr-variant-3-prime
rs4654 -- 26,337,222(+) CCCTA(C/T)AAAAT utr-variant-3-prime
rs8311 -- 26,337,157(-) CCACT(G/T)TGTAG utr-variant-3-prime
rs9442 -- 26,335,572(-) AAAAT(C/T)GAGAA utr-variant-3-prime
rs708156 -- 26,539,439(-) TGTAG(A/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPR2 Gene

Variant ID Type Subtype PubMed ID
esv2579102 CNV Deletion 19546169
esv2257606 CNV Deletion 18987734
esv1000864 CNV Deletion 20482838
esv4216 CNV Deletion 18987735
esv2745657 CNV Deletion 23290073
esv993210 CNV Deletion 20482838
esv6587 CNV Loss 19470904
esv2519123 CNV Deletion 19546169
esv1263874 CNV Deletion 17803354
nsv524588 CNV Loss 19592680
nsv649 CNV Insertion 18451855
nsv832355 CNV Gain 17160897
esv1562553 CNV Insertion 17803354
esv268924 CNV Insertion 20981092
esv272411 CNV Insertion 20981092
nsv898934 CNV Loss 21882294
esv1705858 CNV Insertion 17803354
esv2745658 CNV Deletion 23290073
esv2745659 CNV Deletion 23290073
esv2745660 CNV Deletion 23290073
esv2745661 CNV Deletion 23290073
esv2633425 CNV Insertion 19546169
esv273704 CNV Insertion 20981092
esv269318 CNV Insertion 20981092
esv2653675 CNV Deletion 19546169

Relevant External Links for ITPR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPR2 Gene

Disorders for ITPR2 Gene

Relevant External Links for ITPR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ITPR2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ITPR2 Gene

Publications for ITPR2 Gene

  1. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. (PMID: 8081734) Yamamoto-Hino M. … Mikoshiba K. (Recept. Channels 1994) 2 3 4
  2. ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. (PMID: 17827064) van Es M.A. … van den Berg L.H. (Lancet Neurol 2007) 3 23 48
  3. Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. (PMID: 18936250) Tovey S.C. … Taylor C.W. (J. Cell Biol. 2008) 3 23
  4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 48
  5. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. (PMID: 19193627) ChiA^ A. … Traynor B.J. (Hum. Mol. Genet. 2009) 3 48

Products for ITPR2 Gene

Sources for ITPR2 Gene

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