Aliases for ITPR2 Gene
External Ids for ITPR2 Gene
Previous GeneCards Identifiers for ITPR2 Gene
GeneCards Summary for ITPR2 Gene
ITPR2 (Inositol 1,4,5-Trisphosphate Receptor, Type 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include phosphatidylinositol binding and calcium ion transmembrane transporter activity. An important paralog of this gene is RYR1.
UniProtKB/Swiss-Prot for ITPR2 Gene
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.