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Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3
  • ARAF1 3 4 6
  • PKS2 3 4 6
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 64
  • RAFA1 3 6
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Serine/Threonine-Protein Kinase A-Raf 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 64
  • A-RAF 3
  • PKS 4

External Ids for ARAF Gene

Previous Symbols for ARAF Gene

  • ARAF1

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include mycobacterium marinum. Among its related pathways are Glioma and GPCR Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

  • Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (or c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated by a number of factors including phosphatases (e.g. PP1, PP2A, PP5), kinases (e.g. Src, ERK, Akt, PKC) and proteins that bind directly to Raf-1 (e.g. RKIP, 14-3-3zeta, KSR, Hsp90). Raf-1 is also thought to be able to dimerize with wild type B-Raf in a Ras-dependent process. B-raf is commonly mutated and thereby activated in many human cancers, the most frequent mutation being the V600E mutation of the kinase domain. Whilst wt b-Raf and Raf-1 are strongly activated by growth factor signals via Ras and Src, a-Raf is only modestly activated and has low basal activity. All three isoforms of Raf are considered to be oncogenic.

Gene Wiki entry for ARAF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

Genomic Location for ARAF Gene

Start:
47,561,100 bp from pter
End:
47,571,921 bp from pter
Size:
10,822 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAF Gene

Regulatory Elements for ARAF Gene

Proteins for ARAF Gene

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Interacts with TH1L/NELFD.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Proteomics data for ARAF Gene at MOPED

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAF Gene

Domains for ARAF Gene

Gene Families for ARAF Gene

UniProtKB/Swiss-Prot:

ARAF_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P10398
  • Contains 1 RBD (Ras-binding) domain.:
    • P10398
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.:
    • P10398
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.:
    • P10398
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function: Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Enzyme Numbers (IUBMB) for ARAF Gene

Gene Ontology (GO) - Molecular Function for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 3029685
GO:0004674 protein serine/threonine kinase activity IDA 19667065
GO:0004713 protein tyrosine kinase activity --
GO:0005057 receptor signaling protein activity IEA --
GO:0005515 protein binding IPI 11909642
genes like me logo Genes that share ontologies with ARAF: view
genes like me logo Genes that share phenotypes with ARAF: view

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

No data available for Transcription Factor Targeting and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAF Gene COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion --
genes like me logo Genes that share ontologies with ARAF: view

Pathways for ARAF Gene

genes like me logo Genes that share pathways with ARAF: view

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 3029685
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction --
GO:0032006 regulation of TOR signaling IMP 22609986
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 22609986
genes like me logo Genes that share ontologies with ARAF: view

Compounds for ARAF Gene

(13) ApexBio Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 selective RAF inhibitor. [878739-06-1]
B-Raf inhibitor useful in the treatment of cancer and proliferative diseases. [1315330-11-0]
BRAF inhibitor a potent BRAF inhibitor. [918505-61-0]
CEP-32496 Potent BRAF inhibitor [1188910-76-0]
Dabrafenib Mesylate (GSK-2118436) selective BRAFV600E inhibitor [1195768-06-9]
GDC-0879 Potent and selective B-Raf inhibitor [905281-76-7]
PF-04880594 RAF inhibitor for BRAF/BRAFV599E and c-RAF. [1111636-35-1]
PLX-4720 Potent and selective inhibitor of BRAF with V600E mutation [918505-84-7]
RAF265 Potent and selective Raf inhibitor, also inhibits VEGFR [927880-90-8]
Sorafenib Multi-target kinase inhibitor of Raf kinases and tyrosine kinases [284461-73-0]
TAK-632 Pan-Raf inhibitor [1228591-30-7]
Vemurafenib (PLX4032, RG7204) Potent and selective inhibitor of BRAF with V600E mutation [918504-65-1]
ZM336372 reversible tyrosine kinase modulator selectively inhibiting protein kinase Raf-1. [208260-29-1]

(5) Tocris Compounds for ARAF Gene

Compound Action Cas Number
GDC 0879 Potent B-Raf inhibitor [905281-76-7]
GW 5074 Potent, selective c-Raf1 kinase inhibitor [220904-83-6]
L-779,450 Potent Raf kinase inhibitor [303727-31-3]
SB 590885 Potent B-Raf inhibitor [405554-55-4]
ZM 336372 Potent, selective c-Raf inhibitor [208260-29-1]

(845) HMDB Compounds for ARAF Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available

(1) Drugbank Compounds for ARAF Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine triphosphate
  • 5'-ATP
56-65-5 target

(38) Novoseek inferred chemical compound relationships for ARAF Gene

Compound -log(P) Hits PubMed IDs
6-deoxyerythronolide b 91.8 13
pikromycin 90.1 5
10-deoxymethynolide 89.2 1
methymycin 86.6 1
mycolactone 85.6 6
genes like me logo Genes that share compounds with ARAF: view

Transcripts for ARAF Gene

Unigene Clusters for ARAF Gene

V-raf murine sarcoma 3611 viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARAF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARAF Gene

GeneLoc Exon Structure for
ARAF
ECgene alternative splicing isoforms for
ARAF

Expression for ARAF Gene

mRNA expression in normal human tissues for ARAF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARAF Gene

SOURCE GeneReport for Unigene cluster for ARAF Gene Hs.446641

mRNA Expression by UniProt/SwissProt for ARAF Gene

P10398-ARAF_HUMAN
Tissue specificity: Predominantly in urogenital tissues
genes like me logo Genes that share expressions with ARAF: view

Orthologs for ARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARAF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARAF 36
  • 92.9 (n)
  • 96.53 (a)
ARAF 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARAF 36
  • 93.95 (n)
  • 97.19 (a)
ARAF 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Araf 36
  • 90.29 (n)
  • 95.53 (a)
Araf 16
Araf 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARAF 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAF 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Araf 36
  • 90.62 (n)
  • 95.86 (a)
lizard
(Anolis carolinensis)
Reptilia ARAF 37
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii araf 36
  • 65.62 (n)
  • 71.01 (a)
araf 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta phl 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-45 37
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10630 37
  • 36 (a)
OneToMany
Species with no ortholog for ARAF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARAF Gene

ENSEMBL:
Gene Tree for ARAF (if available)
TreeFam:
Gene Tree for ARAF (if available)

Paralogs for ARAF Gene

Selected SIMAP similar genes for ARAF Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ARAF Gene

genes like me logo Genes that share paralogs with ARAF: view

Variants for ARAF Gene

Sequence variations from dbSNP and Humsavar for ARAF Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1050133 -- 47,569,938(+) GCTTC(C/T)AGTCA reference, stop-gained
rs1130962 -- 47,570,004(+) ACAGC(C/T)ACATT reference, missense
rs2071776 -- 47,565,216(-) GACAC(A/G)GGTCA intron-variant
rs2071777 -- 47,564,400(-) AGGAA(A/C)CCCAC intron-variant
rs2187804 -- 47,560,580(-) GAAGG(G/T)AGCAC upstream-variant-2KB

Relevant External Links for ARAF Gene

HapMap Linkage Disequilibrium report
ARAF
Locus Specific Mutation Databases (LSDB)
ARAF

No data available for Structural Variations from Database of Genomic Variants (DGV) for ARAF Gene

Disorders for ARAF Gene

(1) MalaCards Diseases for ARAF Gene

Search for ARAF Gene in MalaCards »

(4) Novoseek inferred disease relationships for ARAF Gene

Disease -log(P) Hits PubMed IDs
cancer 2.69 2
aids 0 1
ovarian cancer 0 2
tuberculosis 0 1
genes like me logo Genes that share disorders with ARAF: view

No data available for UniProtKB/Swiss-Prot for ARAF Gene

Publications for ARAF Gene

  1. The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PMID: 8020955) Lee J.-E. … Rapp U.R. (Genomics 1994) 3 4 23
  2. Identification of TH1 as an interaction partner of A-Raf kinase. (PMID: 11952167) Yin X.L. … Gu J.X. (Mol. Cell. Biochem. 2002) 3 4 23
  3. Trihydrophobin 1 is a new negative regulator of A-Raf kinase. (PMID: 14684750) Liu W. … Gu J. (J. Biol. Chem. 2004) 3 23
  4. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J. … Gires O. (Cancer Res. 2010) 3 23
  5. The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. (PMID: 3029685) Beck T.W. … Rapp U.R. (Nucleic Acids Res. 1987) 3 4

Products for ARAF Gene

  • Addgene plasmids for ARAF

Sources for ARAF Gene

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