Aliases for ARAF Gene
- A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
- V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
- Proto-Oncogene A-Raf-1 3 4
- Proto-Oncogene Pks 3 4
- EC 126.96.36.199 4 63
- ARAF1 3 4
- PKS2 3 4
- V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
- A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
External Ids for ARAF Gene
Previous HGNC Symbols for ARAF Gene
Previous GeneCards Identifiers for ARAF Gene
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
GeneCards Summary for ARAF Gene
ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Mycobacterium Marinum. Among its related pathways are Glioma and Negative regulation of MAPK pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR1.
UniProtKB/Swiss-Prot for ARAF Gene
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.