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Aliases for ITGAM Gene

Aliases for ITGAM Gene

  • Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit) 2 3
  • Cell Surface Glycoprotein MAC-1 Subunit Alpha 3 4
  • CD11 Antigen-Like Family Member B 3 4
  • Leukocyte Adhesion Receptor MO1 3 4
  • CR-3 Alpha Chain 3 4
  • CD11B 3 4
  • CR3A 3 4
  • Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (P170), Macrophage Antigen Alpha Polypeptide) 2
  • Neutrophil Adherence Receptor Alpha-M Subunit 3
  • Macrophage Antigen Alpha Polypeptide 3
  • Neutrophil Adherence Receptor 4
  • Antigen CD11b (P170) 3
  • Antigen CD11B (P170) 6
  • Integrin Alpha-M 3
  • CD11b Antigen 4
  • MAC-1 3
  • MAC1A 3
  • SLEB6 3
  • MO1A 3

External Ids for ITGAM Gene

Previous HGNC Symbols for ITGAM Gene

  • CR3A
  • CD11B

Previous GeneCards Identifiers for ITGAM Gene

  • GC16P030449
  • GC16P031767
  • GC16P031268
  • GC16P031307
  • GC16P031168
  • GC16P028833

Summaries for ITGAM Gene

Entrez Gene Summary for ITGAM Gene

  • This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for ITGAM Gene

ITGAM (Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)) is a Protein Coding gene. Diseases associated with ITGAM include systemic lupus erythematous, association with 6 and granulocytopenia. Among its related pathways are Ras signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include heparin binding and heparan sulfate proteoglycan binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAM Gene

  • Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain

Gene Wiki entry for ITGAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAM Gene

Genomics for ITGAM Gene

Regulatory Elements for ITGAM Gene

Genomic Location for ITGAM Gene

Start:
31,259,967 bp from pter
End:
31,332,892 bp from pter
Size:
72,926 bases
Orientation:
Plus strand

Genomic View for ITGAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAM Gene

Proteins for ITGAM Gene

  • Protein details for ITGAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11215-ITAM_HUMAN
    Recommended name:
    Integrin alpha-M
    Protein Accession:
    P11215
    Secondary Accessions:
    • Q4VAK0
    • Q4VAK1
    • Q4VAK2

    Protein attributes for ITGAM Gene

    Size:
    1152 amino acids
    Molecular mass:
    127179 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.

    Three dimensional structures from OCA and Proteopedia for ITGAM Gene

    Alternative splice isoforms for ITGAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGAM Gene

Proteomics data for ITGAM Gene at MOPED

Post-translational modifications for ITGAM Gene

  • Glycosylation at Asn86, Asn240, Asn391, Asn469, Asn692, Asn696, Asn734, Asn801, Asn880, Asn900, Asn911, Asn940, Asn946, Asn978, Asn993, Asn1021, Asn1044, Asn1050, and Asn1075
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGAM Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGAM Gene

Domains for ITGAM Gene

Gene Families for ITGAM Gene

HGNC:

Suggested Antigen Peptide Sequences for ITGAM Gene

Graphical View of Domain Structure for InterPro Entry

P11215

UniProtKB/Swiss-Prot:

ITAM_HUMAN :
  • P11215
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAM: view

Function for ITGAM Gene

Molecular function for ITGAM Gene

GENATLAS Biochemistry: integrin,alpha M,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in vitronectin,fibrinogen,von Willebrand factor,thrombospondin,fibronectin,osteopontin,collagen
UniProtKB/Swiss-Prot Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain

Gene Ontology (GO) - Molecular Function for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001846 opsonin binding IEA --
GO:0001948 glycoprotein binding IPI 15004192
GO:0005515 protein binding IPI 15194813
GO:0008201 heparin binding IEA --
GO:0043395 heparan sulfate proteoglycan binding IEA --
genes like me logo Genes that share ontologies with ITGAM: view
genes like me logo Genes that share phenotypes with ITGAM: view

Animal Models for ITGAM Gene

MGI Knock Outs for ITGAM:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGAM

Clone Products

  • Addgene plasmids for ITGAM
  • R&D Systems cDNA Clones for ITGAM (Integrin alpha M/CD11b)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITGAM Gene

Localization for ITGAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAM Gene COMPARTMENTS Subcellular localization image for ITGAM gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
golgi apparatus 2
lysosome 2
nucleus 2
vacuole 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19234460
genes like me logo Genes that share ontologies with ITGAM: view

Pathways for ITGAM Gene

genes like me logo Genes that share pathways with ITGAM: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002523 leukocyte migration involved in inflammatory response IEA --
GO:0007155 cell adhesion TAS 2563162
GO:0007159 leukocyte cell-cell adhesion --
GO:0007229 integrin-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ITGAM: view

Compounds for ITGAM Gene

(116) Novoseek inferred chemical compound relationships for ITGAM Gene

Compound -log(P) Hits PubMed IDs
fmlp 81.8 80
n-formylmethionyl-leucylphenylalanine 75.2 19
cuprophan 66.3 13
nitroblue tetrazolium 65.6 11
5-oxoete 64.6 6
genes like me logo Genes that share compounds with ITGAM: view

Transcripts for ITGAM Gene

Unigene Clusters for ITGAM Gene

Integrin, alpha M (complement component 3 receptor 3 subunit):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGAM

Clone Products

  • Addgene plasmids for ITGAM
  • R&D Systems cDNA Clones for ITGAM (Integrin alpha M/CD11b)

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITGAM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAM Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1:
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1: -
SP2: -
SP3:

Relevant External Links for ITGAM Gene

GeneLoc Exon Structure for
ITGAM
ECgene alternative splicing isoforms for
ITGAM

Expression for ITGAM Gene

mRNA expression in normal human tissues for ITGAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGAM Gene

This gene is overexpressed in Whole Blood (31.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGAM Gene

SOURCE GeneReport for Unigene cluster for ITGAM Gene Hs.172631

mRNA Expression by UniProt/SwissProt for ITGAM Gene

P11215-ITAM_HUMAN
Tissue specificity: Predominantly expressed in monocytes and granulocytes
genes like me logo Genes that share expressions with ITGAM: view

In Situ Assay Products

Orthologs for ITGAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAM 35
  • 99.25 (n)
  • 99.05 (a)
ITGAM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGAM 35
  • 81.34 (n)
  • 75.78 (a)
ITGAM 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGAM 35
  • 81.68 (n)
  • 76.12 (a)
ITGAM 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgam 35
  • 78.61 (n)
  • 74.93 (a)
Itgam 16
Itgam 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Itgam 35
  • 77.99 (n)
  • 73.59 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia itgad 35
  • 52.48 (n)
  • 43.73 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882585 35
  • 47.15 (n)
  • 38.26 (a)
si:dkey-32n7.4 36
  • 36 (a)
ManyToMany
Species with no ortholog for ITGAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAM Gene

ENSEMBL:
Gene Tree for ITGAM (if available)
TreeFam:
Gene Tree for ITGAM (if available)

Paralogs for ITGAM Gene

Selected SIMAP similar genes for ITGAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITGAM: view

Variants for ITGAM Gene

Sequence variations from dbSNP and Humsavar for ITGAM Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs929868 -- 31,268,961(-) tctat(C/T)gcaat intron-variant
rs929870 -- 31,268,791(-) TGATG(G/T)AAACA intron-variant
rs1141617 -- 31,332,370(-) CAGTG(G/T)GCATC utr-variant-3-prime
rs1143677 -- 31,331,251(+) CTGGC(C/T)CTCAT reference, synonymous-codon
rs1143678 - 31,331,684(+) GGGGT(C/T)CCCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ITGAM Gene

Variant ID Type Subtype PubMed ID
esv2436135 CNV Deletion 19546169
esv2052288 CNV Deletion 18987734
esv2714193 CNV Deletion 23290073
esv1039007 CNV Deletion 17803354

Relevant External Links for ITGAM Gene

HapMap Linkage Disequilibrium report
ITGAM
Human Gene Mutation Database (HGMD)
ITGAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAM Gene

Disorders for ITGAM Gene

(1) OMIM Diseases for ITGAM Gene (120980)

UniProtKB/Swiss-Prot

ITAM_HUMAN
  • Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(73) Novoseek inferred disease relationships for ITGAM Gene

Disease -log(P) Hits PubMed IDs
inflammation 58.5 37
shwartzman reaction 48.3 1
necrosis 48.3 31
leukemia 45.9 5
myeloid leukemia 45 2

Relevant External Links for ITGAM

Genetic Association Database (GAD)
ITGAM
Human Genome Epidemiology (HuGE) Navigator
ITGAM
genes like me logo Genes that share disorders with ITGAM: view

Publications for ITGAM Gene

  1. The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression. (PMID: 1683702) Shelley C.S. … Arnaout M.A. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). (PMID: 19129174) Han S. … Nath S.K. (Hum. Mol. Genet. 2009) 3 23 48
  3. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PMID: 18204446) Harley J.B. … Kelly J.A. (Nat. Genet. 2008) 3 4 48
  4. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. (PMID: 18204448) Nath S.K. … Harley J.B. (Nat. Genet. 2008) 3 4 48
  5. N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa. (PMID: 3539202) Pierce M.W. … Arnaout M.A. (Biochim. Biophys. Acta 1986) 3 4

Products for ITGAM Gene

  • Addgene plasmids for ITGAM

Sources for ITGAM Gene

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