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Aliases for ITGAL Gene

Aliases for ITGAL Gene

  • Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide) 2 3
  • CD11A 3 4 6
  • Leukocyte Function-Associated Molecule 1 Alpha Chain 3 4
  • Leukocyte Adhesion Glycoprotein LFA-1 Alpha Chain 3 4
  • CD11 Antigen-Like Family Member A 3 4
  • LFA-1A 3 4
  • LFA1A 3 6
  • Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide 3
  • Lymphocyte Function-Associated Antigen 1 3
  • Integrin Gene Promoter 3
  • Integrin Alpha-L 3
  • CD11a Antigen 4
  • LFA-1 Alpha 3
  • LFA-1 3

External Ids for ITGAL Gene

Previous Symbols for ITGAL Gene

  • CD11A

Summaries for ITGAL Gene

Entrez Gene Summary for ITGAL Gene

  • ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGAL Gene

ITGAL (Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide)) is a Protein Coding gene. Diseases associated with ITGAL include benign cephalic histiocytosis and cutaneous necrotizing vasculitis. Among its related pathways are Ras signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include cell adhesion molecule binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAL Gene

  • Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes

Gene Wiki entry for ITGAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAL Gene

Genomics for ITGAL Gene

Genomic Location for ITGAL Gene

Start:
30,472,658 bp from pter
End:
30,523,185 bp from pter
Size:
50,528 bases
Orientation:
Plus strand

Genomic View for ITGAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAL Gene

Regulatory Elements for ITGAL Gene

Transcription factor binding sites by QIAGEN in the ITGAL gene promoter:

Proteins for ITGAL Gene

  • Protein details for ITGAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20701-ITAL_HUMAN
    Recommended name:
    Integrin alpha-L
    Protein Accession:
    P20701
    Secondary Accessions:
    • O43746
    • Q45H73
    • Q96HB1
    • Q9UBC8

    Protein attributes for ITGAL Gene

    Size:
    1170 amino acids
    Molecular mass:
    128770 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

    Three dimensional structures from OCA and Proteopedia for ITGAL Gene

    Alternative splice isoforms for ITGAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGAL Gene

Proteomics data for ITGAL Gene at MOPED

Post-translational modifications for ITGAL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys93, Lys321, Lys371, Lys416, Lys776, Lys831, Lys836, Lys950, and Lys664
  • Glycosylation at Asn65, Asn89, Asn188, Asn649, Asn670, Asn726, Asn730, Asn862, Asn885, Asn897, Asn1060, and Asn1071

No data available for DME Specific Peptides for ITGAL Gene

Domains for ITGAL Gene

Gene Families for ITGAL Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

UniProtKB/Swiss-Prot:

ITAL_HUMAN
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage:
    • P20701
  • Contains 1 VWFA domain.:
    • P20701
Family:
  • Belongs to the integrin alpha chain family.:
    • P20701
Similarity:
  • Contains 7 FG-GAP repeats.:
    • P20701
genes like me logo Genes that share domains with ITGAL: view

Function for ITGAL Gene

Molecular function for ITGAL Gene

GENATLAS Biochemistry: integrin,alpha L,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB2 in ICAM1/ICAM2 receptor
UniProtKB/Swiss-Prot Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes

Gene Ontology (GO) - Molecular Function for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11544294
GO:0030369 ICAM-3 receptor activity IMP 19029120
GO:0032403 protein complex binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with ITGAL: view
genes like me logo Genes that share phenotypes with ITGAL: view

Animal Models for ITGAL Gene

MGI Knock Outs for ITGAL:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITGAL Gene

Localization for ITGAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAL Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAL Gene COMPARTMENTS Subcellular localization image for ITGAL gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0008305 integrin complex NAS 8103515
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGAL: view

Pathways for ITGAL Gene

genes like me logo Genes that share pathways with ITGAL: view

Gene Ontology (GO) - Biological Process for ITGAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
GO:0006928 movement of cell or subcellular component TAS 10477596
GO:0006954 inflammatory response NAS 8103515
GO:0007155 cell adhesion NAS 8103515
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 2477710
genes like me logo Genes that share ontologies with ITGAL: view

Compounds for ITGAL Gene

(96) Novoseek inferred chemical compound relationships for ITGAL Gene

Compound -log(P) Hits PubMed IDs
efalizumab 78.4 23
lfa703 70.8 2
slex 66.6 15
celgosivir 61.6 1
nkh 1 52.3 2
genes like me logo Genes that share compounds with ITGAL: view

Transcripts for ITGAL Gene

Unigene Clusters for ITGAL Gene

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for ITGAL Gene

GeneLoc Exon Structure for
ITGAL
ECgene alternative splicing isoforms for
ITGAL

Expression for ITGAL Gene

mRNA expression in normal human tissues for ITGAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGAL Gene

This gene is overexpressed in Whole Blood (25.6) and Spleen (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGAL Gene

SOURCE GeneReport for Unigene cluster for ITGAL Gene Hs.174103

mRNA Expression by UniProt/SwissProt for ITGAL Gene

P20701-ITAL_HUMAN
Tissue specificity: Leukocytes
genes like me logo Genes that share expressions with ITGAL: view

Orthologs for ITGAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAL 36
  • 99.29 (n)
  • 99.23 (a)
ITGAL 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGAL 36
  • 82.66 (n)
  • 77.56 (a)
ITGAL 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGAL 36
  • 83.36 (n)
  • 78.92 (a)
ITGAL 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itgal 36
  • 77.86 (n)
  • 73.19 (a)
Itgal 16
Itgal 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGAL 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGAL 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itgal 36
  • 78.28 (n)
  • 73.61 (a)
lizard
(Anolis carolinensis)
Reptilia ITGAL 37
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ITGAL 37
  • 30 (a)
OneToOne
zmp:0000001082 36
  • 48.58 (n)
  • 36.81 (a)
Species with no ortholog for ITGAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAL Gene

ENSEMBL:
Gene Tree for ITGAL (if available)
TreeFam:
Gene Tree for ITGAL (if available)

Paralogs for ITGAL Gene

Selected SIMAP similar genes for ITGAL Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ITGAL: view

Variants for ITGAL Gene

Sequence variations from dbSNP and Humsavar for ITGAL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1064524 - 30,481,502(+) TTAAA(C/T)GGAAG reference, missense
rs1064525 -- 30,522,575(+) GATGA(C/T)GCCTC utr-variant-3-prime
rs1064526 -- 30,522,579(+) ATGCC(G/T)CATGA utr-variant-3-prime
rs1141668 -- 30,522,676(+) GGGCC(G/T)Gggct utr-variant-3-prime
rs1557672 -- 30,499,250(-) GAGCA(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAL Gene

Variant ID Type Subtype PubMed ID
nsv1783 CNV Loss 18451855
nsv905726 CNV Loss 21882294
nsv1784 CNV Insertion 18451855

Relevant External Links for ITGAL Gene

HapMap Linkage Disequilibrium report
ITGAL

Disorders for ITGAL Gene

(5) University of Copenhagen DISEASES for ITGAL Gene

(88) Novoseek inferred disease relationships for ITGAL Gene

Disease -log(P) Hits PubMed IDs
psoriasis 58.1 15
inflammation 52.1 32
necrosis 49.8 28
leukemia t-cell 34.5 4
lichen planus 33.6 5

Relevant External Links for ITGAL

Genetic Association Database (GAD)
ITGAL
Human Genome Epidemiology (HuGE) Navigator
ITGAL
genes like me logo Genes that share disorders with ITGAL: view

No data available for UniProtKB/Swiss-Prot for ITGAL Gene

Publications for ITGAL Gene

  1. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. (PMID: 10493852) Kallen J. … Hommel U. (J. Mol. Biol. 1999) 3 4 23 25
  2. Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter. (PMID: 8103515) Nueda A. … Corbi A.L. (J. Biol. Chem. 1993) 3 4 23
  3. Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter. (PMID: 8097887) Cornwell R.D. … Hickstein D.D. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  4. Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. (PMID: 11792712) Ma Q. … Springer T.A. (J. Biol. Chem. 2002) 3 23
  5. LFA-1 integrin and the microtubular cytoskeleton are involved in the Ca(2)(+)-mediated regulation of the activity of the tyrosine kinase PYK2 in T cells. (PMID: 11867690) RodrA-guez-FernA!ndez J.L. … CabaA+as C. (J. Leukoc. Biol. 2002) 3 23

Products for ITGAL Gene

  • Addgene plasmids for ITGAL

Sources for ITGAL Gene

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