Aliases for ITGAE Gene
- Integrin Subunit Alpha E 2 3 5
- Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide) 2 3
- Mucosal Lymphocyte 1 Antigen 3 4
- Integrin Alpha-IEL 3 4
- Antigen CD103 2 3
- HML-1 Antigen 3 4
- Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide 3
- Human Mucosal Lymphocyte Antigen 1, Alpha Polypeptide 3
External Ids for ITGAE Gene
Previous GeneCards Identifiers for ITGAE Gene
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAE Gene
ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Diseases associated with ITGAE include hairy cell leukemia and splenic marginal zone lymphoma. Among its related pathways are Regulation of actin cytoskeleton and Dendritic Cells Developmental Lineage Pathway. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGAE Gene
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.