Aliases for ITGAE Gene
- Integrin Subunit Alpha E 2 3 5
- Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide) 2 3
- Mucosal Lymphocyte 1 Antigen 3 4
- Integrin Alpha-IEL 3 4
- Antigen CD103 2 3
- HML-1 Antigen 3 4
- Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide 3
- Human Mucosal Lymphocyte Antigen 1, Alpha Polypeptide 3
External Ids for ITGAE Gene
Previous GeneCards Identifiers for ITGAE Gene
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAE Gene
ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Diseases associated with ITGAE include hairy cell leukemia and splenic marginal zone lymphoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Degradation of the extracellular matrix. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGAE Gene
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.