Aliases for ITGAE Gene
Aliases for ITGAE Gene
- Integrin Subunit Alpha E 2 3 5
- Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide) 2 3
- Human Mucosal Lymphocyte Antigen 1, Alpha Polypeptide 2 3
- Mucosal Lymphocyte 1 Antigen 3 4
- Integrin Alpha-IEL 3 4
- HML-1 Antigen 3 4
- Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide 3
External Ids for ITGAE Gene
- HGNC: 6147
- Entrez Gene: 3682
- Ensembl: ENSG00000083457
- OMIM: 604682
- UniProtKB: P38570
Previous GeneCards Identifiers for ITGAE Gene
- GC17M003930
- GC17M003960
- GC17M003568
- GC17M003824
- GC17M003564
- GC17M003513
- GC17M003617
Summaries for ITGAE Gene
-
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAE Gene
ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Diseases associated with ITGAE include Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma. Among its related pathways are Integrin Pathway and ERK Signaling. An important paralog of this gene is ITGAD.
UniProtKB/Swiss-Prot for ITGAE Gene
-
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Additional gene information for ITGAE Gene
- Monarch Initiative
- Search for ITGAE at DataMed
- Search for ITGAE at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAE Gene
Genomics for ITGAE Gene
GeneHancer (GH) Regulatory Elements for ITGAE Gene
- Top Transcription factor binding sites by QIAGEN in the ITGAE gene promoter:
Regulatory Element Products
Genomic Locations for ITGAE Gene
- chr17:3,714,625-3,801,243
- (GRCh38/hg38)
- Size:
- 86,619 bases
- Orientation:
- Minus strand
- chr17:3,617,919-3,704,537
- (GRCh37/hg19)
Genomic View for ITGAE Gene
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC


RefSeq DNA sequence for ITGAE Gene
Proteins for ITGAE Gene
-
Protein details for ITGAE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P38570-ITAE_HUMAN
- Recommended name:
- Integrin alpha-E
- Protein Accession:
- P38570
- Q17RS6
- Q9NZU9
Protein attributes for ITGAE Gene
- Size:
- 1179 amino acids
- Molecular mass:
- 130159 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.
Protein Expression for ITGAE Gene
Post-translational modifications for ITGAE Gene
- Glycosylation at posLast=4949, isoforms=271, isoforms=321, posLast=444444, posLast=726726, posLast=782782, isoforms=857, posLast=934934, posLast=954954, isoforms=1065, and posLast=10961096
Other Protein References for ITGAE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ITGAE (Integrin alpha E/CD103)
- Novus Biologicals Antibodies for ITGAE
-
Abcam antibodies for ITGAE
- Invitrogen Antibodies for ITGAE
- GeneTex ITGAE antibody for ITGAE
-
Santa Cruz Biotechnology (SCBT) Antibodies for ITGAE
- Sino Biological Antibodies for ITGAE
Protein Products
-
OriGene Purified Proteins for ITGAE
- Search Origene for MassSpec and Protein Over-expression Lysates for ITGAE
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- antibodies-online: Search results for 12 available ITGAE Proteins ranked by validation data
- Compare Top ITGAE Proteins
-
Quality Products:
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-
Abcam proteins for ITGAE
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for ITGAE (Integrin alpha E/CD103)
No data available for DME Specific Peptides for ITGAE Gene
Domains & Families for ITGAE Gene
Gene Families for ITGAE Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ITGAE Gene
Suggested Antigen Peptide Sequences for ITGAE Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P38570UniProtKB/Swiss-Prot:
ITAE_HUMAN :- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Belongs to the integrin alpha chain family.
- Domain:
-
- The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
- Family:
-
- Belongs to the integrin alpha chain family.
Function for ITGAE Gene
Molecular function for ITGAE Gene
- UniProtKB/Swiss-Prot Function:
- Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
- UniProtKB/Swiss-Prot Induction:
- Integrin alpha-E/beta-7 is induced by TGFB1.
Phenotypes From GWAS Catalog for ITGAE Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ITGAE Gene
- MGI mutant phenotypes for ITGAE:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ITGAE:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ITGAE gene
-
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- Search ViGene Biosciences for ITGAE
CRISPR Products
-
OriGene CRISPR knockouts for ITGAE
- genomics-online: gRNA clones - Search results for 94 available ITGAE gene related products
- Overview of 94 available ITGAE gene related products
- Applied Biological Materials CRISPR for ITGAE
-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for ITGAE
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAE
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ITGAE
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAE (Integrin alpha E/CD103)
Cell Line Products
-
Horizon Cell Lines for ITGAE
-
ViGene Biosciences adenoviral particle packaged cDNA for ITGAE gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITGAE Gene
Localization for ITGAE Gene
Subcellular locations from UniProtKB/Swiss-Prot for ITGAE Gene
- Membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0008305 | integrin complex | IEA,TAS | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGAE Gene
Pathways & Interactions for ITGAE Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
.66
.65
|
.57
|
2 | ERK Signaling |
.61
.58
|
.49
|
3 | Integrin Pathway |
.67
.67
.56
|
.56
|
4 | MAPK-Erk Pathway |
.38
|
.38
|
5 | Actin Nucleation by ARP-WASP Complex |
.41
.35
|
Pathways by source for ITGAE Gene
5 Sino Biological pathways for ITGAE Gene
3 BioSystems pathways for ITGAE Gene
2 Reactome pathways for ITGAE Gene
1 KEGG pathway for ITGAE Gene
2 R&D Systems pathways for ITGAE Gene
Interacting Proteins for ITGAE Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA | -- |
GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
GO:0030198 | extracellular matrix organization | TAS | -- |
Drugs & Compounds for ITGAE Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
RGD (Arg-Gly-Asp) Peptides | Pharma | Inhibits integrin binding to RGD motifs | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(1) ApexBio Compounds for ITGAE Gene
Compound | Action | Cas Number |
---|---|---|
RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | 99896-85-2 |
Transcripts for ITGAE Gene
mRNA/cDNA for ITGAE Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (158) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ITGAE Gene
CRISPR Products
-
OriGene CRISPR knockouts for ITGAE
- genomics-online: gRNA clones - Search results for 94 available ITGAE gene related products
- Overview of 94 available ITGAE gene related products
- Applied Biological Materials CRISPR for ITGAE
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ITGAE
- GenScript: Design CRISPR guide RNA sequences for ITGAE
miRNA Products
- Search ViGene Biosciences for ITGAE
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ITGAE
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- genomics-online: shRNA clones - Search results for 94 available ITGAE gene related products
- Overview of 94 available ITGAE gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ITGAE gene
Clone Products
- Sino Biological Human cDNA Clone for ITGAE
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ITGAE
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAE
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ITGAE
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ITGAE (Integrin alpha E/CD103)
Expression for ITGAE Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAE Gene
NURSA nuclear receptor signaling pathways regulating expression of ITGAE Gene:
ITGAESOURCE GeneReport for Unigene cluster for ITGAE Gene:
Hs.513867mRNA Expression by UniProt/SwissProt for ITGAE Gene:
P38570-ITAE_HUMANEvidence on tissue expression from TISSUES for ITGAE Gene
- Blood(4.6)
- Lymph node(3.5)
- Spleen(3.5)
- Intestine(2.9)
- Lung(2.7)
- Bone marrow(2.6)
- Skin(2.5)
Primer Products
-
OriGene qPCR primer pairs for ITGAE
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGAE Gene
Orthologs for ITGAE Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ITGAE 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ITGAE 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ITGAE 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Itgae 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Itgae 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | ITGAE 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | ITGAE 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
zebrafish (Danio rerio) |
Actinopterygii | LOC100536705 33 |
|
||
ITGAE (1 of 2) 34 |
|
OneToMany | |||
ITGAE (2 of 2) 34 |
|
OneToMany |
- Species where no ortholog for ITGAE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ITGAE Gene
Variants for ITGAE Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000021781 | -- | 3,758,941(-) | T/C | intron_variant | |
rs1000062386 | -- | 3,723,509(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
rs1000076146 | -- | 3,729,228(-) | G/A/T | genic_downstream_transcript_variant, intron_variant | |
rs1000087857 | -- | 3,764,971(-) | C/G | intron_variant | |
rs1000090084 | -- | 3,798,271(-) | C/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1004185 | CNV | insertion | 20482838 |
esv1749908 | CNV | insertion | 17803354 |
esv24017 | CNV | loss | 19812545 |
esv2761940 | CNV | gain | 21179565 |
esv3639754 | CNV | loss | 21293372 |
esv3892952 | CNV | loss | 25118596 |
esv996976 | CNV | deletion | 20482838 |
nsv1055740 | CNV | gain | 25217958 |
nsv1065489 | CNV | gain | 25217958 |
nsv1071327 | CNV | deletion | 25765185 |
nsv1109044 | CNV | deletion | 24896259 |
nsv1116181 | CNV | deletion | 24896259 |
nsv1948 | CNV | deletion | 18451855 |
nsv1949 | CNV | insertion | 18451855 |
nsv469791 | CNV | loss | 16826518 |
nsv574237 | CNV | loss | 21841781 |
nsv833342 | CNV | loss | 17160897 |
Additional Variant Information for ITGAE Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAE Gene
Disorders for ITGAE Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
hairy cell leukemia |
|
|
splenic marginal zone lymphoma |
|
|
enteropathy-associated t-cell lymphoma |
|
|
refractory celiac disease |
|
|
mycosis fungoides |
|
Additional Disease Information for ITGAE
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAE Gene
Publications for ITGAE Gene
- Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. (PMID: 8119947) Shaw SK … Parker CM (The Journal of biological chemistry 1994) 2 3 4 22 58
- A family of beta 7 integrins on human mucosal lymphocytes. (PMID: 1542691) Parker CM … Brenner MB (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
- Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients. (PMID: 20417566) Liu YH … Tsai FJ (Ophthalmology 2010) 3 44 58
Products for ITGAE Gene
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- Invitrogen Antibodies for ITGAE
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- VectorBuilder custom plasmid, inducible vectors for ITGAE
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ITGAE
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 345 available ITGAE Antibodies ranked by validation data
- Compare Top ITGAE Antibodies
- Quality Products:
- antibodies-online: Search results for available ITGAE related products ranked by validation data
- antibodies-online: Search results for 12 available ITGAE Proteins ranked by validation data
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- genomics-online: cdna clones - Search results for 94 available ITGAE gene related products
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- Overview of 94 available ITGAE gene related products
- genomics-online: shRNA clones - Search results for 94 available ITGAE gene related products
- Overview of 94 available ITGAE gene related products
Sources for ITGAE Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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