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ITGAE Gene(Protein Coding)

Integrin Subunit Alpha E

GCID:
GC17M003722
GIFtS:
62
Genes Participants
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Aliases for ITGAE Gene

Aliases for ITGAE Gene

  • Integrin Subunit Alpha E 2 3 5
  • Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide) 2 3
  • Mucosal Lymphocyte 1 Antigen 3 4
  • Integrin Alpha-IEL 3 4
  • Antigen CD103 2 3
  • HML-1 Antigen 3 4
  • Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide 3
  • Human Mucosal Lymphocyte Antigen 1, Alpha Polypeptide 3
  • Human Mucosal Lymphocyte Antigen 1 2
  • Alpha Polypeptide 2
  • Integrin Alpha E 3
  • CD103 Antigen 4
  • HUMINAE 3
  • CD103 3

External Ids for ITGAE Gene

Previous GeneCards Identifiers for ITGAE Gene

  • GC17M003930
  • GC17M003960
  • GC17M003568
  • GC17M003824
  • GC17M003564
  • GC17M003513
  • GC17M003617

Summaries for ITGAE Gene

Entrez Gene Summary for ITGAE Gene

  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGAE Gene

ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Diseases associated with ITGAE include Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAE Gene

  • Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Gene Wiki entry for ITGAE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAE Gene

Genomics for ITGAE Gene

Products:

  1. Regulatory Element

Regulatory Elements for ITGAE Gene

Enhancers for ITGAE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITGAE on UCSC Golden Path with GeneCards custom track

Promoters for ITGAE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGAE on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ITGAE gene promoter:

Genomic Location for ITGAE Gene

Chromosome:
17
Start:
3,714,625 bp from pter
End:
3,801,243 bp from pter
Size:
86,619 bases
Orientation:
Minus strand

Genomic View for ITGAE Gene

Genes around ITGAE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAE Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ITGAE Gene

Proteins for ITGAE Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ITGAE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38570-ITAE_HUMAN
    Recommended name:
    Integrin alpha-E
    Protein Accession:
    P38570
    Secondary Accessions:
    • Q17RS6
    • Q9NZU9

    Protein attributes for ITGAE Gene

    Size:
    1179 amino acids
    Molecular mass:
    130159 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

neXtProt entry for ITGAE Gene

Proteomics data for ITGAE Gene at MOPED

Protein Expression for ITGAE Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ITGAE Gene

  • Glycosylation at Asn 49, Asn 271, Asn 321, Asn 444, Asn 726, Asn 782, Asn 857, Asn 934, Asn 954, Asn 1065, and Asn 1096
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGAE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGAE (Integrin alpha E/CD103)

No data available for DME Specific Peptides for ITGAE Gene

Domains & Families for ITGAE Gene

Gene Families for ITGAE Gene

HGNC:

Protein Domains for ITGAE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ITGAE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P38570

UniProtKB/Swiss-Prot:

ITAE_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAE: view

Function for ITGAE Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ITGAE Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
UniProtKB/Swiss-Prot Induction:
Integrin alpha-E/beta-7 is induced by TGFB1.

Phenotypes for ITGAE Gene

MGI mutant phenotypes for ITGAE:
inferred from 2 alleles
GenomeRNAi human phenotypes for ITGAE:
genes like me logo Genes that share phenotypes with ITGAE: view

Animal Models for ITGAE Gene

MGI Knock Outs for ITGAE:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITGAE Gene

Localization for ITGAE Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAE Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAE Gene COMPARTMENTS Subcellular localization image for ITGAE gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 2
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ITGAE Gene

Pathways & Interactions for ITGAE Gene

genes like me logo Genes that share pathways with ITGAE: view

SIGNOR curated interactions for ITGAE Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGAE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ITGAE: view

Drugs & Compounds for ITGAE Gene

Products:

  1. Drug

(1) Drugs for ITGAE Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
RGD (Arg-Gly-Asp) Peptides Pharma Inhibits integrin binding to RGD motifs 0

(1) Additional Compounds for ITGAE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ITGAE Gene

Compound Action Cas Number
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
genes like me logo Genes that share compounds with ITGAE: view

Transcripts for ITGAE Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ITGAE Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(158) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITGAE Gene

Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAE Gene

No ASD Table

Relevant External Links for ITGAE Gene

GeneLoc Exon Structure for
ITGAE
ECgene alternative splicing isoforms for
ITGAE

Expression for ITGAE Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ITGAE Gene

mRNA expression in normal human tissues for ITGAE Gene
mRNA expression by BioGPS for ITGAE GenemRNA expression by GTEx for ITGAE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ITGAE Gene

This gene is overexpressed in Liver (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAE Gene



SOURCE GeneReport for Unigene cluster for ITGAE Gene Hs.513867

mRNA Expression by UniProt/SwissProt for ITGAE Gene

P38570-ITAE_HUMAN
Tissue specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
genes like me logo Genes that share expression patterns with ITGAE: view

Protein tissue co-expression partners for ITGAE Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ITGAE Gene

Orthologs for ITGAE Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ITGAE 35
  • 82.39 (n)
  • 75.13 (a)
ITGAE 36
  • 74 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ITGAE 35
  • 79.69 (n)
  • 72.16 (a)
ITGAE 36
  • 72 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Itgae 35
  • 78.81 (n)
  • 70.63 (a)
Itgae 16
Itgae 36
  • 70 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ITGAE 35
  • 98.75 (n)
  • 98.38 (a)
ITGAE 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Itgae 35
  • 78.35 (n)
  • 70.27 (a)
oppossum
(Monodelphis domestica)
 Mammalia ITGAE 36
  • 48 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ITGAE 36
  • 49 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 24 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii LOC100536705 35
  • 48.06 (n)
  • 36.83 (a)
ITGAE (1 of 2) 36
  • 28 (a)
 OneToMany
ITGAE (2 of 2) 36
  • 24 (a)
 OneToMany
Species with no ortholog for ITGAE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAE Gene

ENSEMBL:
Gene Tree for ITGAE (if available)
TreeFam:
Gene Tree for ITGAE (if available)

Paralogs for ITGAE Gene

Paralogs for ITGAE Gene

Pseudogenes.org Pseudogenes for ITGAE Gene

genes like me logo Genes that share paralogs with ITGAE: view

Variants for ITGAE Gene

Sequence variations from dbSNP and Humsavar for ITGAE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_008884 -
VAR_008885 -
rs3744679 - 3,732,446(-) ATTCA(C/G)TGTGA intron-variant, nc-transcript-variant, reference, missense
rs1716 - 3,729,542(-) AAAGA(C/T)GGTCT intron-variant, reference, missense
rs220479 - 3,753,881(-) CCTAC(A/G)TCGCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ITGAE Gene

Variant ID Type Subtype PubMed ID
nsv833342 CNV Loss 17160897
nsv1948 CNV Loss 18451855
nsv907570 CNV Gain 21882294
nsv469791 CNV Complex 16826518
esv24017 CNV Loss 19812545
nsv907571 CNV Loss 21882294
nsv1949 CNV Insertion 18451855
esv996976 CNV Deletion 20482838
esv1004185 CNV Insertion 20482838
esv1749908 CNV Insertion 17803354

Variation tolerance for ITGAE Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAE Gene

Human Gene Mutation Database (HGMD)
ITGAE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAE Gene

Disorders for ITGAE Gene

MalaCards: The human disease database

(9) MalaCards diseases for ITGAE Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ITGAE in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAE

Genetic Association Database (GAD)
ITGAE
Human Genome Epidemiology (HuGE) Navigator
ITGAE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAE
genes like me logo Genes that share disorders with ITGAE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAE Gene

Publications for ITGAE Gene

  1. Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. (PMID: 8119947) Shaw S.K. … Parker C.M. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. (PMID: 16920912) Uss E. … ten Berge I.J. (J. Immunol. 2006) 3 23
  3. Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells. (PMID: 15196058) Hadley G. (Am. J. Transplant. 2004) 3 23
  4. Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease. (PMID: 14532999) Oshitani N. … Arakawa T. (Int. J. Mol. Med. 2003) 3 23
  5. E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation. (PMID: 12414996) Kutlesa S. … Klein G. (J. Cell. Sci. 2002) 3 23

Products for ITGAE Gene

Sources for ITGAE Gene

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