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Aliases for ITGA5 Gene

Aliases for ITGA5 Gene

  • Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) 2 3
  • Fibronectin Receptor Subunit Alpha 3 4
  • CD49 Antigen-Like Family Member E 3 4
  • Integrin Alpha-F 3 4
  • VLA-5 3 4
  • FNRA 3 4
  • Very Late Activation Protein 5, Alpha Subunit 3
  • Fibronectin Receptor, Alpha Subunit 3
  • CD49e Antigen 4
  • CD49e 3
  • VLA5A 3

External Ids for ITGA5 Gene

Previous HGNC Symbols for ITGA5 Gene

  • FNRA

Previous GeneCards Identifiers for ITGA5 Gene

  • GC12M054915
  • GC12M054505
  • GC12M053075
  • GC12M054789
  • GC12M051828

Summaries for ITGA5 Gene

Entrez Gene Summary for ITGA5 Gene

  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA5 Gene

ITGA5 (Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide)) is a Protein Coding gene. Diseases associated with ITGA5 include colon carcinoma in situ and congenital epulis. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA5 Gene

  • Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands

  • (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Tocris Summary for ITGA5 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGA5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA5 Gene

Genomics for ITGA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGA5 Gene

Chromosome:
12
Start:
54,395,261 bp from pter
End:
54,419,460 bp from pter
Size:
24,200 bases
Orientation:
Minus strand

Genomic View for ITGA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA5 Gene

Proteins for ITGA5 Gene

  • Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08648-ITA5_HUMAN
    Recommended name:
    Integrin alpha-5
    Protein Accession:
    P08648
    Secondary Accessions:
    • Q96HA5

    Protein attributes for ITGA5 Gene

    Size:
    1049 amino acids
    Molecular mass:
    114536 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with NOV (PubMed:12695522). (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein (PubMed:12907437). (Microbial infection) Integrin ITGA2:ITGB1 interacts with human parvovirus B19 capsid proteins (PubMed:24478423). (Microbial infection) Interacts with HIV-1 Tat (PubMed:10397733).

    Three dimensional structures from OCA and Proteopedia for ITGA5 Gene

neXtProt entry for ITGA5 Gene

Proteomics data for ITGA5 Gene at MOPED

Post-translational modifications for ITGA5 Gene

  • Proteolytic cleavage by PCSK5 mediates activation of the precursor.
  • Ubiquitination at Lys 215
  • Glycosylation at Asn 84, Asn 182, Asn 297, Asn 307, Asn 316, Asn 524, Asn 530, Asn 593, Asn 609, Asn 675, Asn 712, Asn 724, Asn 771, Asn 773, and Asn 868
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA5 Gene

Antibody Products

  • R&D Systems Antibodies for ITGA5 (Integrin alpha 5/CD49e)
  • Cell Signaling Technology (CST) Antibodies for ITGA5 (ITGA5)

No data available for DME Specific Peptides for ITGA5 Gene

Domains & Families for ITGA5 Gene

Gene Families for ITGA5 Gene

Suggested Antigen Peptide Sequences for ITGA5 Gene

Graphical View of Domain Structure for InterPro Entry

P08648

UniProtKB/Swiss-Prot:

ITA5_HUMAN :
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA5: view

Function for ITGA5 Gene

Molecular function for ITGA5 Gene

GENATLAS Biochemistry:
integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Gene Ontology (GO) - Molecular Function for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 12695522
GO:0043184 vascular endothelial growth factor receptor 2 binding TAS 19267251
genes like me logo Genes that share ontologies with ITGA5: view
genes like me logo Genes that share phenotypes with ITGA5: view

Animal Models for ITGA5 Gene

MGI Knock Outs for ITGA5:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA5

Clone Products

  • Addgene plasmids for ITGA5
  • R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA5 Gene

Localization for ITGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA5 Gene COMPARTMENTS Subcellular localization image for ITGA5 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 colocalizes_with cell-cell junction IDA 14970227
genes like me logo Genes that share ontologies with ITGA5: view

Pathways & Interactions for ITGA5 Gene

genes like me logo Genes that share pathways with ITGA5: view

PCR Array Products

SIGNOR curated interactions for ITGA5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 19267251
GO:0007044 cell-substrate junction assembly IEA --
GO:0007155 cell adhesion TAS 2454952
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007159 leukocyte cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ITGA5: view

Drugs & Compounds for ITGA5 Gene

(12) Drugs for ITGA5 Gene - From: DGIdb, ApexBio, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
thymidine Experimental Pharma 0
Cyclo (-RGDfK) Pharma Inhibitor of αvβ3 integrin 0
RGD (Arg-Gly-Asp) Peptides Pharma Inhibits integrin binding to RGD motifs 0
Cilengitide Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins 0
F200 Pharma 0

(9) Additional Compounds for ITGA5 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BIO 1211
187735-94-0
Echistatin, alpha1 isoform
154303-05-6
Obtustatin
P11
848644-86-0
TCS 2314
317353-73-4
genes like me logo Genes that share compounds with ITGA5: view

Transcripts for ITGA5 Gene

Unigene Clusters for ITGA5 Gene

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA5

Clone Products

  • Addgene plasmids for ITGA5
  • R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ·
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8: -
SP9:
SP10:

Relevant External Links for ITGA5 Gene

GeneLoc Exon Structure for
ITGA5
ECgene alternative splicing isoforms for
ITGA5

Expression for ITGA5 Gene

mRNA expression in normal human tissues for ITGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene

This gene is overexpressed in Artery - Tibial (x8.6) and Colon - Sigmoid (x6.1).

Protein differential expression in normal tissues from HIPED for ITGA5 Gene

This gene is overexpressed in Urinary Bladder (22.7), Seminal vesicle (10.5), and Colon muscle (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA5 Gene



SOURCE GeneReport for Unigene cluster for ITGA5 Gene Hs.505654

genes like me logo Genes that share expression patterns with ITGA5: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ITGA5 Gene

Orthologs for ITGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA5 35
  • 90.44 (n)
  • 92.95 (a)
ITGA5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA5 35
  • 88.37 (n)
  • 92.39 (a)
ITGA5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga5 35
  • 87.45 (n)
  • 90.75 (a)
Itga5 16
Itga5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA5 35
  • 99.49 (n)
  • 99.81 (a)
ITGA5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga5 35
  • 87.22 (n)
  • 90.15 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA5 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ITGA5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga5 35
  • 65.84 (n)
  • 67 (a)
Str.3950 35
African clawed frog
(Xenopus laevis)
Amphibia itga5-A 35
zebrafish
(Danio rerio)
Actinopterygii itga5 35
  • 61.05 (n)
  • 57.77 (a)
itga5 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 37
  • 26 (a)
alphaPS5 37
  • 26 (a)
if 37
  • 31 (a)
scb 37
  • 24 (a)
if 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F54F2.1 37
  • 30 (a)
ina-1 37
  • 25 (a)
pat-2 36
  • 26 (a)
OneToMany
Species with no ortholog for ITGA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA5 Gene

ENSEMBL:
Gene Tree for ITGA5 (if available)
TreeFam:
Gene Tree for ITGA5 (if available)

Paralogs for ITGA5 Gene

(5) SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITGA5: view

Variants for ITGA5 Gene

Sequence variations from dbSNP and Humsavar for ITGA5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_049631 -

Structural Variations from Database of Genomic Variants (DGV) for ITGA5 Gene

Variant ID Type Subtype PubMed ID
esv2745915 CNV Deletion 23290073

Variation tolerance for ITGA5 Gene

Residual Variation Intolerance Score: 5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA5 Gene

HapMap Linkage Disequilibrium report
ITGA5
Human Gene Mutation Database (HGMD)
ITGA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene

Disorders for ITGA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ITGA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colon carcinoma in situ
  • stage 0 colonic carcinoma
congenital epulis
  • congenital granular cell tumor
transitional papilloma
  • transitional cell papilloma nos
hiv-1
  • aids, slow progression to
- elite association
Search ITGA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGA5

Genetic Association Database (GAD)
ITGA5
Human Genome Epidemiology (HuGE) Navigator
ITGA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA5
genes like me logo Genes that share disorders with ITGA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA5 Gene

Publications for ITGA5 Gene

  1. VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression. (PMID: 19460753) Tanaka R. … Fukai F. (J. Biol. Chem. 2009) 23 67
  2. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. (PMID: 19843692) Hamidouche Z. … Marie P.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  3. An immunohistochemical study of beta1 integrin molecules (VLA-4, VLA-5, VLA-6) in all endometrial compartments of fertile and infertile women in Ahwaz-Iran. (PMID: 19579970) Boroujerdnia M.G. … Mosthophy N.E. (Pak. J. Biol. Sci. 2009) 23 67
  4. CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model. (PMID: 18186923) Orazizadeh M. … Salter D.M. (Arthritis Res. Ther. 2008) 23 67
  5. Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. (PMID: 18381440) Sawada K. … Lengyel E. (Cancer Res. 2008) 23 67

Products for ITGA5 Gene

  • Addgene plasmids for ITGA5

Sources for ITGA5 Gene

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