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Aliases for ITGA5 Gene

Aliases for ITGA5 Gene

  • Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) 2 3
  • Fibronectin Receptor Subunit Alpha 3 4
  • CD49 Antigen-Like Family Member E 3 4
  • Integrin Alpha-F 3 4
  • VLA-5 3 4
  • FNRA 3 4
  • Very Late Activation Protein 5, Alpha Subunit 3
  • Fibronectin Receptor, Alpha Subunit 3
  • Very Late Activation Protein-5 6
  • Integrin Alpha-5 3
  • Alpha Subunit) 6
  • CD49e Antigen 4
  • CD49e 3
  • VLA5A 3

External Ids for ITGA5 Gene

Previous Symbols for ITGA5 Gene

  • FNRA

Summaries for ITGA5 Gene

Entrez Gene Summary for ITGA5 Gene

  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]

GeneCards Summary for ITGA5 Gene

ITGA5 (Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide)) is a Protein Coding gene. Diseases associated with ITGA5 include gastric cardia adenocarcinoma. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include integrin binding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA5 Gene

  • Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions

Tocris Summary for ITGA5 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA5 Gene

Genomics for ITGA5 Gene

Genomic Location for ITGA5 Gene

Start:
54,395,261 bp from pter
End:
54,419,460 bp from pter
Size:
24,200 bases
Orientation:
Minus strand

Genomic View for ITGA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA5 Gene

Proteins for ITGA5 Gene

  • Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08648-ITA5_HUMAN
    Recommended name:
    Integrin alpha-5
    Protein Accession:
    P08648
    Secondary Accessions:
    • Q96HA5

    Protein attributes for ITGA5 Gene

    Size:
    1049 amino acids
    Molecular mass:
    114536 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat. Interacts with CIB1.

    Three dimensional structures from OCA and Proteopedia for ITGA5 Gene

neXtProt entry for ITGA5 Gene

Proteomics data for ITGA5 Gene at MOPED

Post-translational modifications for ITGA5 Gene

  • Proteolytic cleavage by PCSK5 mediates activation of the precursor.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys215
  • Glycosylation at Asn84, Asn182, Asn297, Asn307, Asn316, Asn524, Asn530, Asn593, Asn609, Asn675, Asn712, Asn724, Asn771, Asn773, and Asn868

Other Protein References for ITGA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGA5 Gene

Domains for ITGA5 Gene

Gene Families for ITGA5 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGA5 Gene

Graphical View of Domain Structure for InterPro Entry

P08648

UniProtKB/Swiss-Prot:

ITA5_HUMAN
Family:
  • Belongs to the integrin alpha chain family.:
    • P08648
Similarity:
  • Contains 7 FG-GAP repeats.:
    • P08648
genes like me logo Genes that share domains with ITGA5: view

Function for ITGA5 Gene

Molecular function for ITGA5 Gene

GENATLAS Biochemistry: integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor
UniProtKB/Swiss-Prot Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions

Gene Ontology (GO) - Molecular Function for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 14970227
GO:0043184 vascular endothelial growth factor receptor 2 binding TAS 19267251
genes like me logo Genes that share ontologies with ITGA5: view
genes like me logo Genes that share phenotypes with ITGA5: view

Animal Models for ITGA5 Gene

MGI Knock Outs for ITGA5:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA5 Gene

Localization for ITGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA5 Gene COMPARTMENTS Subcellular localization image for ITGA5 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
cytosol 2
extracellular 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 colocalizes_with cell-cell junction IDA 14970227
GO:0005925 colocalizes_with focal adhesion IDA 14970227
genes like me logo Genes that share ontologies with ITGA5: view

Pathways for ITGA5 Gene

genes like me logo Genes that share pathways with ITGA5: view

Gene Ontology (GO) - Biological Process for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 19267251
GO:0007044 cell-substrate junction assembly IEA --
GO:0007155 cell adhesion TAS 2454952
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007159 leukocyte cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ITGA5: view

Compounds for ITGA5 Gene

(5) Tocris Compounds for ITGA5 Gene

Compound Action Cas Number
A 286982 Potent inhibitor of the LFA-1/ICAM-1 interaction [280749-17-9]
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
Leukadherin 1 Allosteric activator of CD11b/CD18 [344897-95-6]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(7) Novoseek inferred chemical compound relationships for ITGA5 Gene

Compound -log(P) Hits PubMed IDs
grgdsp 69.6 4
tyrosine 23 3
procollagen 18.5 2
agarose 0 1
thymidine 0 1
genes like me logo Genes that share compounds with ITGA5: view

Transcripts for ITGA5 Gene

Unigene Clusters for ITGA5 Gene

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ·
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8: -
SP9:
SP10:

Relevant External Links for ITGA5 Gene

GeneLoc Exon Structure for
ITGA5
ECgene alternative splicing isoforms for
ITGA5

Expression for ITGA5 Gene

mRNA expression in normal human tissues for ITGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene

This gene is overexpressed in Artery - Tibial (8.6) and Colon - Sigmoid (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA5 Gene

SOURCE GeneReport for Unigene cluster for ITGA5 Gene Hs.505654

genes like me logo Genes that share expressions with ITGA5: view

No data available for mRNA Expression by UniProt/SwissProt for ITGA5 Gene

Orthologs for ITGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA5 35
  • 99.49 (n)
  • 99.81 (a)
ITGA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA5 35
  • 90.44 (n)
  • 92.95 (a)
ITGA5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA5 35
  • 88.37 (n)
  • 92.39 (a)
ITGA5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga5 35
  • 87.45 (n)
  • 90.75 (a)
Itga5 16
Itga5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA5 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga5 35
  • 87.22 (n)
  • 90.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ITGA5 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia itga5-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itga5 35
  • 65.84 (n)
  • 67 (a)
Str.3950 35
zebrafish
(Danio rerio)
Actinopterygii itga5 35
  • 61.05 (n)
  • 57.77 (a)
itga5 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta if 36
  • 24 (a)
OneToMany
if 37
  • 31 (a)
scb 37
  • 24 (a)
alphaPS5 37
  • 26 (a)
alphaPS4 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-2 36
  • 26 (a)
OneToMany
F54F2.1 37
  • 30 (a)
ina-1 37
  • 25 (a)
Species with no ortholog for ITGA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA5 Gene

ENSEMBL:
Gene Tree for ITGA5 (if available)
TreeFam:
Gene Tree for ITGA5 (if available)

Paralogs for ITGA5 Gene

Selected SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITGA5: view

Variants for ITGA5 Gene

Sequence variations from dbSNP and Humsavar for ITGA5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9653 -- 54,395,372(-) CCCTC(A/C)TCTCT utr-variant-3-prime
rs1134714 -- 54,395,715(-) CAGGG(C/G)CCAGA utr-variant-3-prime
rs1134880 -- 54,395,366(-) TCTCT(C/T)TGCCC utr-variant-3-prime
rs1249180 -- 54,409,918(+) gtagc(A/G)tgatc intron-variant
rs1249181 -- 54,411,981(-) GCCTC(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA5 Gene

Variant ID Type Subtype PubMed ID
esv2745915 CNV Deletion 23290073

Relevant External Links for ITGA5 Gene

HapMap Linkage Disequilibrium report
ITGA5
Human Gene Mutation Database (HGMD)
ITGA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene

Disorders for ITGA5 Gene

(2) University of Copenhagen DISEASES for ITGA5 Gene

(13) Novoseek inferred disease relationships for ITGA5 Gene

Disease -log(P) Hits PubMed IDs
myeloma 33.3 4
colon carcinoma 20.7 4
lymphoblastic leukemia acute 20 2
melanoma 19.3 3
hepatocellular carcinoma 16.1 5

Relevant External Links for ITGA5

Genetic Association Database (GAD)
ITGA5
Human Genome Epidemiology (HuGE) Navigator
ITGA5
genes like me logo Genes that share disorders with ITGA5: view

No data available for UniProtKB/Swiss-Prot for ITGA5 Gene

Publications for ITGA5 Gene

  1. Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood. (PMID: 7542116) Turner M.L. … Parker A.C. (Stem Cells 1995) 3 23
  2. Correlation between integrin alpha 5 expression and the malignant phenotype of transitional cell carcinoma. (PMID: 8562338) Saito T. … Tomita Y. (Br. J. Cancer 1996) 3 23
  3. cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide. (PMID: 2944883) Argraves W.S. … Ruoslahti E. (J. Biol. Chem. 1986) 3 4
  4. Amino acid sequence of the human fibronectin receptor. (PMID: 2958481) Argraves W.S. … Ruoslahti E. (J. Cell Biol. 1987) 3 4
  5. The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. (PMID: 3033641) Takada Y. … Hemler M.E. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4

Products for ITGA5 Gene

  • Addgene plasmids for ITGA5

Sources for ITGA5 Gene

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