Aliases for ITGA3 Gene
External Ids for ITGA3 Gene
Previous HGNC Symbols for ITGA3 Gene
Previous GeneCards Identifiers for ITGA3 Gene
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ITGA3 Gene
ITGA3 (Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor)) is a Protein Coding gene. Diseases associated with ITGA3 include interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital and interstitial lung disease. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA3 Gene
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.