Aliases for ITGA2B Gene
- Integrin Subunit Alpha 2b 2 3 5
- Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41) 2 3
- Platelet Glycoprotein IIb Of IIb/IIIa Complex 2 3
- Protein Phosphatase 1, Regulatory Subunit 93 2 3
- Platelet Membrane Glycoprotein IIb 3 4
- GPalpha IIb 3 4
- GPIIb 3 4
- GP2B 3 4
- Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41B) 2
- Platelet Fibrinogen Receptor, Alpha Subunit 3
- Platelet-Specific Antigen BAK 3
- Integrin Alpha-IIb 3
External Ids for ITGA2B Gene
Previous HGNC Symbols for ITGA2B Gene
Previous GeneCards Identifiers for ITGA2B Gene
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
GeneCards Summary for ITGA2B Gene
ITGA2B (Integrin Subunit Alpha 2b) is a Protein Coding gene. Diseases associated with ITGA2B include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16, Autosomal Dominant. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include identical protein binding and fibrinogen binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA2B Gene
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.