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Aliases for IRF7 Gene

Aliases for IRF7 Gene

  • Interferon Regulatory Factor 7 2 3 5
  • IRF-7 3 4
  • Interferon Regulatory Factor-7H 3
  • IRF-7H 3
  • IMD39 3
  • IRF7A 3
  • IRF7B 3
  • IRF7C 3
  • IRF7H 3

External Ids for IRF7 Gene

Previous GeneCards Identifiers for IRF7 Gene

  • GC11P001127
  • GC11P001065
  • GC11P000583
  • GC11M000427

Summaries for IRF7 Gene

Entrez Gene Summary for IRF7 Gene

  • IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF7 Gene

IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include immunodeficiency 39 and vaccinia. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Toll-like receptor signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF7 Gene

  • Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Gene Wiki entry for IRF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF7 Gene

Genomics for IRF7 Gene

Regulatory Elements for IRF7 Gene

Enhancers for IRF7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRF7 on UCSC Golden Path with GeneCards custom track

Promoters for IRF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IRF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRF7 Gene

Chromosome:
11
Start:
612,553 bp from pter
End:
615,999 bp from pter
Size:
3,447 bases
Orientation:
Minus strand

Genomic View for IRF7 Gene

Genes around IRF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF7 Gene

Proteins for IRF7 Gene

  • Protein details for IRF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92985-IRF7_HUMAN
    Recommended name:
    Interferon regulatory factor 7
    Protein Accession:
    Q92985
    Secondary Accessions:
    • B9EGL3
    • O00331
    • O00332
    • O00333
    • O75924
    • Q9UE79

    Protein attributes for IRF7 Gene

    Size:
    503 amino acids
    Molecular mass:
    54278 Da
    Quaternary structure:
    • Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2 and LMP1 as well as human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1. Interacts with MYD88 AND TRAF6.

    Three dimensional structures from OCA and Proteopedia for IRF7 Gene

    Alternative splice isoforms for IRF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF7 Gene

Proteomics data for IRF7 Gene at MOPED

Post-translational modifications for IRF7 Gene

  • Acetylation inhibits its DNA-binding ability and activity.
  • In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.
  • Sumoylated by TRIM28, which inhibits its transactivation activity.
  • TRAF6-mediated ubiquitination is required for IRF7 activation.
  • Ubiquitination at Lys 120 and Lys 341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IRF7 Gene

Domains & Families for IRF7 Gene

Suggested Antigen Peptide Sequences for IRF7 Gene

Graphical View of Domain Structure for InterPro Entry

Q92985

UniProtKB/Swiss-Prot:

IRF7_HUMAN :
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Belongs to the IRF family.
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF7: view

No data available for Gene Families for IRF7 Gene

Function for IRF7 Gene

Molecular function for IRF7 Gene

GENATLAS Biochemistry:
interferon regulatory factor 7,with three alternatively spliced isoforms,predominantly expressed in spleen,thymus and peripheral blood leukocytes regulator (? activator,? repressor) of IFNA,IFN-stimulated genes and Epstein-Barr virus
UniProtKB/Swiss-Prot EnzymeRegulation:
In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.
UniProtKB/Swiss-Prot Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.
genes like me logo Genes that share phenotypes with IRF7: view

Human Phenotype Ontology for IRF7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF7 Gene

MGI Knock Outs for IRF7:

Animal Model Products

miRNA for IRF7 Gene

miRTarBase miRNAs that target IRF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IRF7 Gene

Localization for IRF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF7 Gene

Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF7 Gene COMPARTMENTS Subcellular localization image for IRF7 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IRF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19176627
genes like me logo Genes that share ontologies with IRF7: view

Pathways & Interactions for IRF7 Gene

genes like me logo Genes that share pathways with IRF7: view

SIGNOR curated interactions for IRF7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IRF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9315633
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0002819 regulation of adaptive immune response IDA 17404045
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IRF7: view

Drugs & Compounds for IRF7 Gene

(2) Drugs for IRF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for IRF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF7: view

Transcripts for IRF7 Gene

Unigene Clusters for IRF7 Gene

Interferon regulatory factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IRF7 Gene

GeneLoc Exon Structure for
IRF7
ECgene alternative splicing isoforms for
IRF7

Expression for IRF7 Gene

mRNA expression in normal human tissues for IRF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRF7 Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for IRF7 Gene

This gene is overexpressed in Plasma (31.8) and Heart (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRF7 Gene



SOURCE GeneReport for Unigene cluster for IRF7 Gene Hs.166120

mRNA Expression by UniProt/SwissProt for IRF7 Gene

Q92985-IRF7_HUMAN
Tissue specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with IRF7: view

Protein tissue co-expression partners for IRF7 Gene

Primer Products

In Situ Assay Products

Orthologs for IRF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRF7 35
  • 77.78 (n)
  • 72.63 (a)
IRF7 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf7 35
  • 72.86 (n)
  • 69.69 (a)
Irf7 16
Irf7 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRF7 35
  • 98.46 (n)
  • 98.29 (a)
IRF7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf7 35
  • 72.55 (n)
  • 69.76 (a)
dog
(Canis familiaris)
Mammalia IRF7 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRF-3 36
  • 38 (a)
OneToOne
IRF7 35
  • 55.24 (n)
  • 44.47 (a)
lizard
(Anolis carolinensis)
Reptilia IRF7 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496395 35
  • 49.07 (n)
  • 42.62 (a)
zebrafish
(Danio rerio)
Actinopterygii irf7 36
  • 32 (a)
OneToOne
irf7 35
  • 44.21 (n)
  • 34.99 (a)
Species with no ortholog for IRF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF7 Gene

ENSEMBL:
Gene Tree for IRF7 (if available)
TreeFam:
Gene Tree for IRF7 (if available)

Paralogs for IRF7 Gene

Paralogs for IRF7 Gene

(3) SIMAP similar genes for IRF7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with IRF7: view

Variants for IRF7 Gene

Sequence variations from dbSNP and Humsavar for IRF7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1061502 - 614,318(-) GTGAC(A/G)AGGGG reference, missense
rs1131665 - 613,208(-) CTTCC(A/G)AGGTC reference, missense
rs41313489 - 614,243(+) TGGAT(C/T)TGCCC reference, missense
VAR_073779 Immunodeficiency 39 (IMD39)
rs1051390 -- 613,165(-) GGGTC(C/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF7 Gene

Variant ID Type Subtype PubMed ID
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
nsv467634 CNV Loss 19166990
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
dgv936n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
nsv528415 CNV Loss 19592680
nsv896560 CNV Loss 21882294
dgv940n71 CNV Loss 21882294
dgv941n71 CNV Loss 21882294
nsv896569 CNV Loss 21882294

Variation tolerance for IRF7 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRF7 Gene

HapMap Linkage Disequilibrium report
IRF7
Human Gene Mutation Database (HGMD)
IRF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF7 Gene

Disorders for IRF7 Gene

MalaCards: The human disease database

(11) MalaCards diseases for IRF7 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 39
  • imd39
vaccinia
pediatric lymphoma
  • childhood lymphoma
hepatitis c
  • chronic hepatitis c
influenza
  • flu
- elite association - COSMIC cancer census association via MalaCards
Search IRF7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IRF7_HUMAN
  • Immunodeficiency 39 (IMD39) [MIM:616345]: A primary immunodeficiency causing severe, life-threatening acute respiratory distress upon infection with H1N1 influenza A. {ECO:0000269 PubMed:25814066}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IRF7

Genetic Association Database (GAD)
IRF7
Human Genome Epidemiology (HuGE) Navigator
IRF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRF7
genes like me logo Genes that share disorders with IRF7: view

No data available for Genatlas for IRF7 Gene

Publications for IRF7 Gene

  1. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. (PMID: 12374802) Caillaud A. … Marie I. (J. Biol. Chem. 2002) 3 4 23 67
  2. Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1. (PMID: 19858727) Zekri A.R. … Esmat G. (Eur J Gastroenterol Hepatol 2010) 3 23
  3. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. (PMID: 20112359) Salloum R. … Niewold T.B. (Arthritis Rheum. 2010) 3 23
  4. Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. (PMID: 20154210) Buss C. … Eitel J. (J. Immunol. 2010) 3 23
  5. Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3. (PMID: 20483755) Sweeney S.E. … Firestein G.S. (J. Immunol. 2010) 3 23

Products for IRF7 Gene

Sources for IRF7 Gene

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