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Aliases for IRF5 Gene

Aliases for IRF5 Gene

  • Interferon Regulatory Factor 5 2 3 5
  • SLEB10 3
  • IRF-5 4

External Ids for IRF5 Gene

Previous GeneCards Identifiers for IRF5 Gene

  • GC07P127056
  • GC07P128118
  • GC07P128131
  • GC07P128171
  • GC07P128365
  • GC07P128577
  • GC07P122939

Summaries for IRF5 Gene

Entrez Gene Summary for IRF5 Gene

  • This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

GeneCards Summary for IRF5 Gene

IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel Disease 14. Among its related pathways are Interferon gamma signaling and p53 Pathway (RnD). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF6.

UniProtKB/Swiss-Prot for IRF5 Gene

  • Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.

Gene Wiki entry for IRF5 Gene

Additional gene information for IRF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF5 Gene

Genomics for IRF5 Gene

Regulatory Elements for IRF5 Gene

Enhancers for IRF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H128932 1.7 FANTOM5 Ensembl ENCODE dbSUPER 51.1 -3.2 -3172 3.3 HDGF PKNOX1 SIN3A BATF ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 IRF5 ATP6V1F KCP ENSG00000242162 FLNC FLNC-AS1 TSPAN33 TNPO3 TPI1P2 LOC392787
GH07H128960 1.5 FANTOM5 Ensembl ENCODE dbSUPER 39.5 +25.0 24950 3.3 PKNOX1 RB1 EBF1 BATF RELA CTBP1 FOS RUNX3 IKZF2 CHD2 IRF5 TNPO3 TPI1P2 ENSG00000242162 ATP6V1F TSPAN33 RN7SL306P ENSG00000275106
GH07H128936 1.2 ENCODE dbSUPER 34.9 +2.0 1974 5.5 HDGF PKNOX1 ARID4B SIN3A GLIS2 ZNF143 ZNF207 ATF7 KLF7 RUNX3 IRF5 KCP ENSG00000242162 FLNC ATP6V1F FLNC-AS1 TPI1P2 TNPO3 TSPAN33 ENSG00000271553
GH07H128953 1 ENCODE dbSUPER 16.2 +17.4 17412 2.1 CTCF MAX SIN3A BMI1 ZBTB40 BATF RFX5 ATF7 ETV6 IKZF2 IRF5 ENSG00000275106 RN7SL306P
GH07H129053 1.2 ENCODE 10 +117.2 117193 2.9 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A MEF2D ZNF610 ENSG00000242588 ENSG00000243302 ENSG00000243679 ENSG00000230715 RPS10P15 ENSG00000243230 RBM28 ENSG00000229413 CDC26P1 NRF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRF5 on UCSC Golden Path with GeneCards custom track

Promoters for IRF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217801 988 1601 RB1 SIN3A NFXL1 GLIS2 SCRT2 ZNF143 KLF7 ETV6 IKZF2 SMARCA5

Transcription factor binding sites by QIAGEN in the IRF5 gene promoter:

Genomic Locations for IRF5 Gene

Genomic Locations for IRF5 Gene
12,431 bases
Plus strand

Genomic View for IRF5 Gene

Genes around IRF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF5 Gene

Proteins for IRF5 Gene

  • Protein details for IRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon regulatory factor 5
    Protein Accession:
    Secondary Accessions:
    • A4D1J8
    • A8DUA8
    • A8DUA9
    • E7EQ16
    • E7EW54
    • Q1A7B4
    • Q64GA9
    • Q64GB1
    • Q64GB2
    • Q6RCM8
    • Q9BQF0

    Protein attributes for IRF5 Gene

    498 amino acids
    Molecular mass:
    56044 Da
    Quaternary structure:
    • Homodimer, when phosphorylated.

    Three dimensional structures from OCA and Proteopedia for IRF5 Gene

    Alternative splice isoforms for IRF5 Gene

neXtProt entry for IRF5 Gene

Post-translational modifications for IRF5 Gene

  • Lys-63-linked polyubiquitination by TRAF6 is required for activation.
  • Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.
  • Ubiquitination at posLast=411411 and posLast=412412
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IRF5 Gene

Domains & Families for IRF5 Gene

Gene Families for IRF5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IRF family.
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF5: view

Function for IRF5 Gene

Molecular function for IRF5 Gene

GENATLAS Biochemistry:
interferon regulatory factor 5,56kDa
UniProtKB/Swiss-Prot Function:
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.

Phenotypes From GWAS Catalog for IRF5 Gene

Gene Ontology (GO) - Molecular Function for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 20237317
genes like me logo Genes that share ontologies with IRF5: view
genes like me logo Genes that share phenotypes with IRF5: view

Human Phenotype Ontology for IRF5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IRF5 Gene

MGI Knock Outs for IRF5:

Animal Model Products

miRNA for IRF5 Gene

miRTarBase miRNAs that target IRF5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRF5 Gene

Localization for IRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF5 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 3
extracellular 2
peroxisome 2
endosome 1

Gene Ontology (GO) - Cellular Components for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22412986
GO:0005737 cytoplasm IEA,IDA 22412986
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IRF5 Gene

Pathways & Interactions for IRF5 Gene

genes like me logo Genes that share pathways with IRF5: view

Pathways by source for IRF5 Gene

SIGNOR curated interactions for IRF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with IRF5: view

Drugs & Compounds for IRF5 Gene

(1) Drugs for IRF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IRF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF5: view

Transcripts for IRF5 Gene

Unigene Clusters for IRF5 Gene

Interferon regulatory factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - -

Relevant External Links for IRF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRF5 Gene

mRNA differential expression in normal tissues according to GTEx for IRF5 Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for IRF5 Gene

This gene is overexpressed in Monocytes (25.1), Blymphocyte (18.8), and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRF5 Gene

Protein tissue co-expression partners for IRF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRF5 Gene:


SOURCE GeneReport for Unigene cluster for IRF5 Gene:


Evidence on tissue expression from TISSUES for IRF5 Gene

  • Kidney(4.2)
  • Spleen(2.6)
  • Blood(2.5)
  • Lymph node(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF5 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • tongue
  • tooth
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • biliary tract
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with IRF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRF5 Gene

Orthologs for IRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRF5 33 34
  • 99.74 (n)
(Canis familiaris)
Mammalia IRF5 33 34
  • 90.71 (n)
(Bos Taurus)
Mammalia IRF5 33 34
  • 86.91 (n)
(Rattus norvegicus)
Mammalia Irf5 33
  • 86.02 (n)
(Mus musculus)
Mammalia Irf5 33 16 34
  • 85.22 (n)
(Ornithorhynchus anatinus)
Mammalia IRF5 34
  • 79 (a)
(Monodelphis domestica)
Mammalia IRF5 34
  • 55 (a)
(Gallus gallus)
Aves IRF5 33 34
  • 65.05 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
(Danio rerio)
Actinopterygii irf5 34
  • 52 (a)
Species where no ortholog for IRF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF5 Gene

Gene Tree for IRF5 (if available)
Gene Tree for IRF5 (if available)

Paralogs for IRF5 Gene

Paralogs for IRF5 Gene Pseudogenes for IRF5 Gene

genes like me logo Genes that share paralogs with IRF5: view

Variants for IRF5 Gene

Sequence variations from dbSNP and Humsavar for IRF5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10954213 other 128,949,373(+) TTAAT(A/G)AATGT utr-variant-3-prime
rs2004640 other 128,938,247(+) TCGGG(G/T)GGGTG intron-variant, splice-donor-variant
rs2070197 other 128,948,946(+) TGGAT(C/T)TGGGC utr-variant-3-prime
rs1000047647 -- 128,937,927(+) GCGGC(A/G)AGACG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000140258 -- 128,946,222(+) CTGGC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF5 Gene

Variant ID Type Subtype PubMed ID
nsv831125 CNV loss 17160897
nsv608415 CNV loss 21841781
esv2735137 CNV deletion 23290073
esv2670312 CNV deletion 23128226
esv22837 CNV gain 19812545

Variation tolerance for IRF5 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.63; 96.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRF5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF5 Gene

Disorders for IRF5 Gene

MalaCards: The human disease database

(15) MalaCards diseases for IRF5 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus 10
  • sleb10
inflammatory bowel disease 14
  • ibd14
diffuse cutaneous systemic sclerosis
  • dcssc
primary biliary cholangitis
  • primary biliary cirrhosis
limited scleroderma
  • limited cutaneous systemic sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search IRF5 in MalaCards View complete list of genes associated with diseases


  • Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17881657}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17599733}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:15657875}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IRF5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRF5: view

No data available for Genatlas for IRF5 Gene

Publications for IRF5 Gene

  1. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. (PMID: 17599733) Sigurdsson S … Rönnblom L (Arthritis and rheumatism 2007) 3 4 22 45 60
  2. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. (PMID: 17881657) Dideberg V … Syvänen AC (Human molecular genetics 2007) 3 4 22 45 60
  3. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. (PMID: 16642019) Graham RR … Alarcón-Riquelme ME (Nature genetics 2006) 3 4 22 45 60
  4. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PMID: 15657875) Sigurdsson S … Syvänen AC (American journal of human genetics 2005) 3 4 22 45 60
  5. Association between IRF-5 polymorphisms and risk of acute coronary syndrome. (PMID: 19778284) Fan JH … Zhang L (DNA and cell biology 2010) 3 22 45 60

Products for IRF5 Gene

Sources for IRF5 Gene

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