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Aliases for IRF4 Gene

Aliases for IRF4 Gene

  • Interferon Regulatory Factor 4 2 3
  • LSIRF 3 4 6
  • Lymphocyte-Specific Interferon Regulatory Factor 3 4
  • Multiple Myeloma Oncogene 1 3 4
  • NF-EM5 3 4
  • MUM1 3 4
  • SHEP8 3
  • IRF-4 4

External Ids for IRF4 Gene

Previous HGNC Symbols for IRF4 Gene

  • MUM1

Previous GeneCards Identifiers for IRF4 Gene

  • GC06U990070
  • GC06P000377
  • GC06P000336

Summaries for IRF4 Gene

Entrez Gene Summary for IRF4 Gene

  • The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for IRF4 Gene

IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include diffuse large b-cell lymphoma and primary effusion lymphoma. Among its related pathways are IL4-mediated signaling events and Interferon Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF4 Gene

  • Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Gene Wiki entry for IRF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF4 Gene

Genomics for IRF4 Gene

Regulatory Elements for IRF4 Gene

Genomic Location for IRF4 Gene

Start:
391,739 bp from pter
End:
411,447 bp from pter
Size:
19,709 bases
Orientation:
Plus strand

Genomic View for IRF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF4 Gene

Proteins for IRF4 Gene

  • Protein details for IRF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15306-IRF4_HUMAN
    Recommended name:
    Interferon regulatory factor 4
    Protein Accession:
    Q15306
    Secondary Accessions:
    • Q5VUI7
    • Q99660

    Protein attributes for IRF4 Gene

    Size:
    451 amino acids
    Molecular mass:
    51772 Da
    Quaternary structure:
    • Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct (By similarity). Interacts with SPIB and DEF6.

    Three dimensional structures from OCA and Proteopedia for IRF4 Gene

    Alternative splice isoforms for IRF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF4 Gene

Proteomics data for IRF4 Gene at MOPED

Post-translational modifications for IRF4 Gene

  • Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IRF4 Gene

Domains for IRF4 Gene

Suggested Antigen Peptide Sequences for IRF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15306

UniProtKB/Swiss-Prot:

IRF4_HUMAN :
  • Q15306
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF4: view

No data available for Gene Families for IRF4 Gene

Function for IRF4 Gene

Molecular function for IRF4 Gene

GENATLAS Biochemistry: interferon regulatory factor 4,lymphocyte-specific, controlling the B-cell proliferation and differentiation,protooncogene deregulated in multiple myeloma with translocation t(6;14)(p25;q32) (see MUM1)
UniProtKB/Swiss-Prot Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
UniProtKB/Swiss-Prot Induction: Not induced by interferons

Gene Ontology (GO) - Molecular Function for IRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12374808
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 12374808
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 12374808
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with IRF4: view
genes like me logo Genes that share phenotypes with IRF4: view

Animal Models for IRF4 Gene

MGI Knock Outs for IRF4:

miRNA for IRF4 Gene

miRTarBase miRNAs that target IRF4
Targeting motifs for IRF4 Gene
HOMER Transcription Factor Regulatory Elements motif IRF4
  • Consensus sequence: ACTGAAACCA Submotif: canonical Cell Type: GM12878 GeoId: GSE32465

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for IRF4 Gene

Localization for IRF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF4 Gene COMPARTMENTS Subcellular localization image for IRF4 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for IRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000788 nuclear nucleosome IEA --
GO:0005634 nucleus IC 12374808
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF4: view

Pathways for IRF4 Gene

genes like me logo Genes that share pathways with IRF4: view

Gene Ontology (GO) - Biological Process for IRF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006479 protein methylation --
GO:0018022 peptidyl-lysine methylation IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IRF4: view

Transcripts for IRF4 Gene

Unigene Clusters for IRF4 Gene

Interferon regulatory factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - -
SP8: - - - -
SP9: -

Relevant External Links for IRF4 Gene

GeneLoc Exon Structure for
IRF4
ECgene alternative splicing isoforms for
IRF4

Expression for IRF4 Gene

mRNA expression in normal human tissues for IRF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRF4 Gene

SOURCE GeneReport for Unigene cluster for IRF4 Gene Hs.401013

mRNA Expression by UniProt/SwissProt for IRF4 Gene

Q15306-IRF4_HUMAN
Tissue specificity: Lymphoid cells
genes like me logo Genes that share expressions with IRF4: view

No data available for mRNA differential expression in normal tissues for IRF4 Gene

Orthologs for IRF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF4 35
  • 99.7 (n)
  • 99.78 (a)
IRF4 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF4 35
  • 89.36 (n)
  • 93.79 (a)
IRF4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF4 35
  • 89.84 (n)
  • 94.65 (a)
IRF4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf4 35
  • 88.15 (n)
  • 92.44 (a)
Irf4 16
Irf4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRF4 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf4 35
  • 88.67 (n)
  • 92.44 (a)
chicken
(Gallus gallus)
Aves IRF-4 36
  • 85 (a)
OneToOne
IRF4 35
  • 80.77 (n)
  • 85.98 (a)
lizard
(Anolis carolinensis)
Reptilia IRF4 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irf4 35
  • 69.75 (n)
  • 73.44 (a)
zebrafish
(Danio rerio)
Actinopterygii irf4a 35
  • 66.59 (n)
  • 65.89 (a)
irf4a 36
  • 62 (a)
OneToMany
irf4b 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for IRF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF4 Gene

ENSEMBL:
Gene Tree for IRF4 (if available)
TreeFam:
Gene Tree for IRF4 (if available)

Paralogs for IRF4 Gene

Paralogs for IRF4 Gene

Selected SIMAP similar genes for IRF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IRF4: view

Variants for IRF4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IRF4 Gene

Q15306-IRF4_HUMAN
Genetic variants in IRF4 define the skin/hair/eye pigmentation variation locus 8 (SHEP8) [MIM:611724]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.

Sequence variations from dbSNP and Humsavar for IRF4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15640 -- 409,189(+) GTTCA(G/T)CCTTT utr-variant-3-prime, nc-transcript-variant
rs872071 -- 411,064(+) AGGGG(A/G)CGTGA utr-variant-3-prime, nc-transcript-variant
rs908029 -- 411,604(+) CGGGC(G/T)GCTCC downstream-variant-500B
rs1050972 -- 401,578(+) GGCCA(C/G)AGGAA missense, reference, nc-transcript-variant
rs1050973 -- 401,596(+) GAGAA(C/G)CTGCT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF4 Gene

Variant ID Type Subtype PubMed ID
dgv1885e1 CNV Complex 17122850
dgv1886e1 CNV Complex 17122850
nsv428134 CNV Gain 18775914
esv581 CNV CNV 17122850
dgv1887e1 CNV Complex 17122850
nsv821644 CNV Gain 15273396
dgv1888e1 CNV Complex 17122850
dgv1889e1 CNV Complex 17122850
nsv830568 CNV Gain+Loss 17160897
dgv1891e1 CNV Complex 17122850
dgv736n27 CNV Loss 19166990
dgv6414n71 CNV Loss 21882294
nsv820552 CNV Duplication 20802225
dgv990n67 CNV Gain 20364138
nsv823390 CNV Gain 20364138
essv23730 CNV CNV 17122850
nsv509115 CNV Insertion 20534489
nsv883359 CNV Gain 21882294
esv2472692 CNV Deletion 19546169
esv2671956 CNV Deletion 23128226
dgv1897e1 CNV Complex 17122850
nsv830569 CNV Gain 17160897
nsv462608 CNV Loss 19166990

Relevant External Links for IRF4 Gene

HapMap Linkage Disequilibrium report
IRF4
Human Gene Mutation Database (HGMD)
IRF4

Disorders for IRF4 Gene

(1) OMIM Diseases for IRF4 Gene (601900)

UniProtKB/Swiss-Prot

IRF4_HUMAN
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:9326949}. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.

(2) University of Copenhagen DISEASES for IRF4 Gene

(18) Novoseek inferred disease relationships for IRF4 Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 76.8 12
lymphoma 58.3 10
leukemia t-cell 55.6 4
lymphoma non-hodgkins 46.8 3
plasmacytoma 46.7 2

Relevant External Links for IRF4

Genetic Association Database (GAD)
IRF4
Human Genome Epidemiology (HuGE) Navigator
IRF4
genes like me logo Genes that share disorders with IRF4: view

Publications for IRF4 Gene

  1. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25. (PMID: 8921401) Grossman A. … Mak T.W. (Genomics 1996) 2 3 4 23
  2. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. (PMID: 18483556) Han J. … Hunter D.J. (PLoS Genet. 2008) 3 4 23 48
  3. Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. (PMID: 18417578) Xu D. … Zhang L. (J. Virol. 2008) 2 3 23
  4. Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma. (PMID: 19396635) Gathany A.H. … Wang S.S. (Cancer Causes Control 2009) 3 23 48
  5. An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males. (PMID: 19897031) Do T.N. … Dorak M.T. (Biochim. Biophys. Acta 2010) 3 23 48

Products for IRF4 Gene

Sources for IRF4 Gene

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