Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IRF2 Gene

Aliases for IRF2 Gene

  • Interferon Regulatory Factor 2 2 3 5
  • IRF-2 3 4

External Ids for IRF2 Gene

Previous GeneCards Identifiers for IRF2 Gene

  • GC04M186336
  • GC04M185988
  • GC04M186004
  • GC04M185684
  • GC04M185545
  • GC04M185308
  • GC04M181063

Summaries for IRF2 Gene

Entrez Gene Summary for IRF2 Gene

  • IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF2 Gene

IRF2 (Interferon Regulatory Factor 2) is a Protein Coding gene. Diseases associated with IRF2 include Eczema Herpeticum and Mumps. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Interferon gamma signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is IRF1.

UniProtKB/Swiss-Prot for IRF2 Gene

  • Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Gene Wiki entry for IRF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF2 Gene

Genomics for IRF2 Gene

Regulatory Elements for IRF2 Gene

Enhancers for IRF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G184353 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +118.5 118491 4.6 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 LINC02363 IRF2 PRIMPOL CDKN2AIP ENSG00000251878 CFAP97 ACSL1 ENSG00000248206 LINC02362
GH04G184342 2 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +128.1 128109 8.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 LINC02363 IRF2 ENSG00000251878 CASP3 PRIMPOL CFAP97 ACSL1 GC04P184303
GH04G184265 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16 +207.3 207288 4.0 HDGF ATF1 PKNOX1 ARID4B TCF12 ZNF766 GATA2 ZNF143 FOS JUNB IRF2 MYL12BP2 CASP3 ENSG00000251878 PRIMPOL LINC02363 LOC105377584 RN7SL28P
GH04G184381 2 VISTA FANTOM5 ENCODE dbSUPER 14.7 +89.6 89552 7.3 HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A YY1 ZNF143 IRF2 ENSG00000251878 LINC02362 RWDD4 ACSL1 GC04P184432
GH04G184287 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +186.2 186211 2.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT MLX ZFP64 WRNIP1 ARID4B SIN3A CASP3 IRF2 ENSG00000251878 PRIMPOL LINC02363 MYL12BP2 ENPP6 CENPU RN7SL28P LOC105377582
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRF2 on UCSC Golden Path with GeneCards custom track

Promoters for IRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176927 480 3801 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for IRF2 Gene

Chromosome:
4
Start:
184,387,713 bp from pter
End:
184,474,580 bp from pter
Size:
86,868 bases
Orientation:
Minus strand

Genomic View for IRF2 Gene

Genes around IRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2 Gene

Proteins for IRF2 Gene

  • Protein details for IRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14316-IRF2_HUMAN
    Recommended name:
    Interferon regulatory factor 2
    Protein Accession:
    P14316
    Secondary Accessions:
    • D6RCK5
    • H0Y8S3
    • Q6IAS7
    • Q96B99

    Protein attributes for IRF2 Gene

    Size:
    349 amino acids
    Molecular mass:
    39354 Da
    Quaternary structure:
    • Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.

    Alternative splice isoforms for IRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF2 Gene

Post-translational modifications for IRF2 Gene

  • Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
  • The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRF2 (IRF2)

No data available for DME Specific Peptides for IRF2 Gene

Domains & Families for IRF2 Gene

Graphical View of Domain Structure for InterPro Entry

P14316

UniProtKB/Swiss-Prot:

IRF2_HUMAN :
  • Belongs to the IRF family.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF2: view

No data available for Gene Families for IRF2 Gene

Function for IRF2 Gene

Molecular function for IRF2 Gene

GENATLAS Biochemistry:
interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1
UniProtKB/Swiss-Prot Function:
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
UniProtKB/Swiss-Prot Induction:
By viruses and IFN.

Gene Ontology (GO) - Molecular Function for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 9540062
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP 9540062
GO:0003677 DNA binding IEA,IDA 9540062
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IMP 9540062
genes like me logo Genes that share ontologies with IRF2: view
genes like me logo Genes that share phenotypes with IRF2: view

Animal Models for IRF2 Gene

MGI Knock Outs for IRF2:

Animal Model Products

Transcription Factor Targets for IRF2 Gene

Selected GeneGlobe predicted Target genes for IRF2
Targeted motifs for IRF2 Gene
HOMER Transcription Factor Regulatory Elements motif IRF2
  • Consensus sequence: GAAASYGAAASY Submotif: canonical Cell Type: Erythroblas GEO ID: GSE36985

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for IRF2 Gene

Localization for IRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with IRF2: view

Pathways & Interactions for IRF2 Gene

genes like me logo Genes that share pathways with IRF2: view

Pathways by source for IRF2 Gene

1 GeneGo (Thomson Reuters) pathway for IRF2 Gene
1 R&D Systems pathway for IRF2 Gene

Gene Ontology (GO) - Biological Process for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7507207
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 9540062
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with IRF2: view

No data available for SIGNOR curated interactions for IRF2 Gene

Drugs & Compounds for IRF2 Gene

(4) Drugs for IRF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for IRF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRF2: view

Transcripts for IRF2 Gene

Unigene Clusters for IRF2 Gene

Interferon regulatory factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - -
SP11: - - -

Relevant External Links for IRF2 Gene

GeneLoc Exon Structure for
IRF2
ECgene alternative splicing isoforms for
IRF2

Expression for IRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRF2 Gene

mRNA differential expression in normal tissues according to GTEx for IRF2 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for IRF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Blymphocyte (23.5), and CD8 Tcells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRF2 Gene



Protein tissue co-expression partners for IRF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRF2 Gene:

IRF2

SOURCE GeneReport for Unigene cluster for IRF2 Gene:

Hs.654566

mRNA Expression by UniProt/SwissProt for IRF2 Gene:

P14316-IRF2_HUMAN
Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria.

Evidence on tissue expression from TISSUES for IRF2 Gene

  • Blood(4.5)
  • Liver(4.4)
  • Skin(4.3)
  • Intestine(3.4)
  • Spleen(2.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with IRF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF2 Gene

Orthologs for IRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia IRF2 34 35
  • 92.26 (n)
oppossum
(Monodelphis domestica)
Mammalia IRF2 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF2 34 35
  • 89.37 (n)
mouse
(Mus musculus)
Mammalia Irf2 34 16 35
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Irf2 34
  • 88.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IRF2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRF2 34 35
  • 79.38 (n)
lizard
(Anolis carolinensis)
Reptilia IRF2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irf2 34
  • 65.79 (n)
Str.2206 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32603 34
zebrafish
(Danio rerio)
Actinopterygii irf2 34
  • 76.4 (n)
IRF2 (2 of 2) 35
  • 56 (a)
OneToMany
irf2a 35
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.42 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToMany
Species where no ortholog for IRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF2 Gene

ENSEMBL:
Gene Tree for IRF2 (if available)
TreeFam:
Gene Tree for IRF2 (if available)

Paralogs for IRF2 Gene

Paralogs for IRF2 Gene

genes like me logo Genes that share paralogs with IRF2: view

Variants for IRF2 Gene

Sequence variations from dbSNP and Humsavar for IRF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000022595 -- 184,458,224(+) GAATA(A/G)AAAGA intron-variant
rs1000061676 -- 184,395,852(+) CTGAA(A/G)AGAGT intron-variant
rs10000856 -- 184,425,049(+) GGCAC(C/T)GGTGC intron-variant
rs1000091324 -- 184,403,416(+) CTCTG(A/G)GTACC intron-variant
rs1000194315 -- 184,425,189(+) AGAGA(A/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF2 Gene

Variant ID Type Subtype PubMed ID
esv29408 CNV loss 19812545
nsv1026074 CNV gain 25217958
nsv1074249 CNV deletion 25765185
nsv515626 CNV loss 19592680
nsv528892 CNV loss 19592680
nsv830167 CNV gain 17160897

Variation tolerance for IRF2 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRF2 Gene

Human Gene Mutation Database (HGMD)
IRF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF2 Gene

Disorders for IRF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IRF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eczema herpeticum
  • eczema herpeticum [ambiguous]
mumps
anogenital venereal wart
  • anogenital human papilloma virus infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search IRF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRF2

Genetic Association Database (GAD)
IRF2
Human Genome Epidemiology (HuGE) Navigator
IRF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRF2
genes like me logo Genes that share disorders with IRF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRF2 Gene

Publications for IRF2 Gene

  1. Regulation of IRF2 transcriptional activity by its sumoylation. (PMID: 18514056) Han K.-J. … Shu H.-B. (Biochem. Biophys. Res. Commun. 2008) 3 4 22 64
  2. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up- regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PMID: 15226432) Oshima S. … Watanabe M. (Mol. Cell. Biol. 2004) 3 4 22 64
  3. Evaluation of the IRF-2 gene as a candidate for PSORS3. (PMID: 14962090) Foerster J. … te Meerman G. (J. Invest. Dermatol. 2004) 3 22 46 64
  4. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PMID: 12799427) Childs K.S. … Goodbourn S. (Nucleic Acids Res. 2003) 3 4 22 64
  5. Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PMID: 11721886) Nishio Y. … Arinami T. (J. Hum. Genet. 2001) 3 22 46 64

Products for IRF2 Gene

Sources for IRF2 Gene

Content
Loading form....