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Aliases for IRF1 Gene

Aliases for IRF1 Gene

  • Interferon Regulatory Factor 1 2 3
  • IRF-1 3 4
  • MAR 3 6
  • Interferon Regulatory Factor 1 Isoform Delta4 3
  • Interferon Regulatory Factor 1 Isoform Delta7 3
  • Interferon Regulatory Factor 1 Isoform +I9 3
  • Interferon Regulatory Factor 1 Isoform D78 3
  • Interferon Regulatory Factor-1 2

External Ids for IRF1 Gene

Previous GeneCards Identifiers for IRF1 Gene

  • GC05M131340
  • GC05M132265
  • GC05M131849
  • GC05M131894
  • GC05M131846
  • GC05M127009
  • GC05M131817

Summaries for IRF1 Gene

Entrez Gene Summary for IRF1 Gene

  • IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF1 Gene

IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include mumps and gastric cancer, somatic. Among its related pathways are Hemostasis and IL6-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF1 Gene

  • Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.

Gene Wiki entry for IRF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF1 Gene

Genomics for IRF1 Gene

Regulatory Elements for IRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRF1 Gene

Start:
132,481,609 bp from pter
End:
132,490,798 bp from pter
Size:
9,190 bases
Orientation:
Minus strand

Genomic View for IRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF1 Gene

Proteins for IRF1 Gene

  • Protein details for IRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10914-IRF1_HUMAN
    Recommended name:
    Interferon regulatory factor 1
    Protein Accession:
    P10914
    Secondary Accessions:
    • Q96GG7

    Protein attributes for IRF1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300.
    Miscellaneous:
    • Deletion or rearrangement of IRF1 are found in preleukemic myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML)

neXtProt entry for IRF1 Gene

Proteomics data for IRF1 Gene at MOPED

Post-translational modifications for IRF1 Gene

  • Phosphorylated by CK2 and this positively regulates its activity.
  • Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.
  • Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.
  • Ubiquitination at Lys50 and Lys299
  • Modification sites at PhosphoSitePlus

Other Protein References for IRF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRF1 (IRF1)

No data available for DME Specific Peptides for IRF1 Gene

Domains for IRF1 Gene

Graphical View of Domain Structure for InterPro Entry

P10914

UniProtKB/Swiss-Prot:

IRF1_HUMAN :
  • P10914
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF1: view

No data available for Gene Families for IRF1 Gene

Function for IRF1 Gene

Molecular function for IRF1 Gene

GENATLAS Biochemistry: interferon regulatory factor 1,transcriptional activator for IFNA,IFNB and IFN-stimulated genes,a modulator of virus-induced signaling,antioncogene deleted in MDS,AML,differentiated gastric adenocarcinomas (see TSG5D),tumor suppressor transcription factor inducing apoptosis of tumorigenic cell lines
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by MYD88.
UniProtKB/Swiss-Prot Function: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
UniProtKB/Swiss-Prot Induction: By viruses and interferon (IFN)

Gene Ontology (GO) - Molecular Function for IRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP 15509808
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 15509808
GO:0003677 DNA binding TAS 11846971
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with IRF1: view
genes like me logo Genes that share phenotypes with IRF1: view

Animal Models for IRF1 Gene

MGI Knock Outs for IRF1:

Animal Model Products

CRISPR Products

miRNA for IRF1 Gene

miRTarBase miRNAs that target IRF1

Transcription Factor Targeting for IRF1 Gene

Selected GeneGlobe predicted Target genes for IRF1
Targeting motifs for IRF1 Gene
HOMER Transcription Factor Regulatory Elements motif IRF1
  • Consensus sequence: GAAAGTGAAAGT Submotif: canonical Cell Type: PBMC GeoId: GSE43036

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for IRF1 Gene

Localization for IRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF1 Gene

Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF1 Gene COMPARTMENTS Subcellular localization image for IRF1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 18035482
GO:0005634 nucleus TAS 11846971
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF1: view

Pathways for IRF1 Gene

genes like me logo Genes that share pathways with IRF1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002819 regulation of adaptive immune response TAS 11846971
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 2475256
GO:0006915 apoptotic process IDA 19851330
GO:0007050 cell cycle arrest IDA 22200613
genes like me logo Genes that share ontologies with IRF1: view

Compounds for IRF1 Gene

(44) Novoseek inferred chemical compound relationships for IRF1 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 70.4 8
ifn-alpha 66.8 9
indoleamine 63 4
am 580 51.7 3
retinoic acid 47.7 47
genes like me logo Genes that share compounds with IRF1: view

Transcripts for IRF1 Gene

Unigene Clusters for IRF1 Gene

Interferon regulatory factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10:

Relevant External Links for IRF1 Gene

GeneLoc Exon Structure for
IRF1
ECgene alternative splicing isoforms for
IRF1

Expression for IRF1 Gene

mRNA expression in normal human tissues for IRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRF1 Gene

This gene is overexpressed in Whole Blood (14.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRF1 Gene

SOURCE GeneReport for Unigene cluster for IRF1 Gene Hs.436061

genes like me logo Genes that share expressions with IRF1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IRF1 Gene

Orthologs for IRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF1 35
  • 99.59 (n)
  • 99.69 (a)
IRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF1 35
  • 89.51 (n)
  • 89.41 (a)
IRF1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF1 35
  • 90.83 (n)
  • 92.81 (a)
IRF1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf1 35
  • 84.51 (n)
  • 85.54 (a)
Irf1 16
Irf1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRF1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf1 35
  • 85.54 (n)
  • 85.23 (a)
chicken
(Gallus gallus)
Aves IRF1 35
  • 69.27 (n)
  • 64.17 (a)
IRF1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF1 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68691 35
tropical clawed frog
(Silurana tropicalis)
Amphibia irf1 35
  • 59.56 (n)
  • 58 (a)
zebrafish
(Danio rerio)
Actinopterygii irf1b 35
  • 59.6 (n)
  • 56.71 (a)
irf1b 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for IRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF1 Gene

ENSEMBL:
Gene Tree for IRF1 (if available)
TreeFam:
Gene Tree for IRF1 (if available)

Paralogs for IRF1 Gene

Paralogs for IRF1 Gene

Selected SIMAP similar genes for IRF1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with IRF1: view

Variants for IRF1 Gene

Sequence variations from dbSNP and Humsavar for IRF1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs839 -- 132,483,434(-) GGGGC(A/G)ATGCT utr-variant-3-prime, nc-transcript-variant
rs960757 -- 132,490,618(-) GCGCT(C/T)CGCGC utr-variant-5-prime, nc-transcript-variant
rs2070721 -- 132,490,150(-) AGGCG(A/C)CAGGT intron-variant
rs2070722 -- 132,488,794(-) GTGGG(G/T)TAGAT intron-variant
rs2070723 -- 132,487,495(-) CCATT(C/T)AGTAA intron-variant

Relevant External Links for IRF1 Gene

HapMap Linkage Disequilibrium report
IRF1
Human Gene Mutation Database (HGMD)
IRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IRF1 Gene

Disorders for IRF1 Gene

(2) OMIM Diseases for IRF1 Gene (147575)

UniProtKB/Swiss-Prot

IRF1_HUMAN
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:10395927, ECO:0000269 PubMed:9679752}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for IRF1 Gene

(76) Novoseek inferred disease relationships for IRF1 Gene

Disease -log(P) Hits PubMed IDs
tumors 47.2 108
necrosis 44.3 15
virus infection 43.6 13
leukemia promyelocytic acute 39.5 3
myelodysplastic syndromes 38.9 6

Relevant External Links for IRF1

Genetic Association Database (GAD)
IRF1
Human Genome Epidemiology (HuGE) Navigator
IRF1
genes like me logo Genes that share disorders with IRF1: view

Publications for IRF1 Gene

  1. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. (PMID: 8438156) Willman C.L. … Taniguchi T. (Science 1993) 3 4 23
  2. Human interferon regulatory factor 1: intron-exon organization. (PMID: 1382447) Cha Y. … Deisseroth A.B. (DNA Cell Biol. 1992) 3 4 23
  3. Functionally inactivating point mutation in the tumor-suppressor IRF- 1 gene identified in human gastric cancer. (PMID: 9679752) Nozawa H. … Tanaka N. (Int. J. Cancer 1998) 3 4 23
  4. A role for casein kinase II phosphorylation in the regulation of IRF- 1 transcriptional activity. (PMID: 10094406) Lin R. … Hiscott J. (Mol. Cell. Biochem. 1999) 3 4 23
  5. Mutation screening of interferon regulatory factor 1 gene (IRF-1) as a candidate gene for atopy/asthma. (PMID: 11069564) Noguchi E. … Hamaguchi H. (Clin. Exp. Allergy 2000) 3 23 48

Products for IRF1 Gene

Sources for IRF1 Gene

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